Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01182610
Details
2012-12-03
Interventional
21 
Carboplatin Fluorouracil Paclitaxel Panitumumab
Adenocarcinoma Adenocarcinoma … Adenocarcinoma … Adenocarcinomas… Gastroesophagea…
Safety concern in a similar trial enrolling the same patient population
This study was closed due to notification and preliminary results from a trial including panitumumab as part of combination chemotherapy for gastroesophageal cancer. The study was closed by mutual consent from the PI, Sponsor, and Funder.
NCT01071902
Details
2012-12-03
Interventional
3400 
Moxifloxacin Pharmaceutical …
Otitis Otitis Media Acute Otitis Me…
Management decision
-
NCT00584090
Details
2012-12-03
Interventional
40 
Solifenacin Suc…
Enuresis Parkinson Disea… Urinary Inconti… Parkinson's Dis…
Study withdrawn with intent of persuing larger, multi-site study.
-
NCT00387348
Details
2012-12-03
Interventional
324 
Citalopram Dexetimide Escitalopram
Bile Duct Neopl… Cholangiocarcin… Depression Depressive Diso… Esophageal Neop… Fatigue Gallbladder Neo… Liver Neoplasms Lung Neoplasms Pancreatic Neop… Stomach Neoplas… Colorectal Canc… Esophageal Canc… Extrahepatic Bi… Gallbladder Can… Gastric Cancer Liver Cancer Lung Cancer Pancreatic Canc…
DSMB stopped study because placebo arm had more adverse events
After an interim analaysis, the DSMB decided to terminate the trial early because of the rate of adverse events (HAM-D scores increasing by at least 25%) and deaths were higher in participants receiving placebo.
NCT01204411
Details
2012-11-30
Interventional
40 
Amodiaquine Artesunate
Malaria Malaria, Falcip… Malnutrition Severe Acute Ma… Child
The ethics committee did not approve the pharmacokinetic part of the study.
-
NCT01151735
Details
2012-11-30
Interventional
40 
Complement C1s
Angioedema Angioedemas, He… Prodromal Sympt… Hereditary Angi…
PennState would not allow the study to move forward
-
NCT00788541
Details
2012-11-30
Interventional
2197 
Anecortave Hydrocortisone
Glaucoma Glaucoma, Open-… Hypertension Ocular Hyperten… Open-Angle Glau…
Project cancellation
-
NCT00332657
Details
2012-11-28
Interventional
336 
Anecortave Hydrocortisone
AMD
Management Decision
-
NCT00307398
Details
2012-11-28
Interventional
32596 
Anecortave Hydrocortisone
Dry AMD
Management decision
-
NCT01055145
Details
2012-11-27
Interventional
3182 
Levofloxacin Moxifloxacin
TB
-
-
NCT00699296
Details
2012-11-27
Interventional
24 
Panobinostat
Leukemia Leukemia, T-Cel… Leukemia-Lympho… Lymphoma Lymphoma, T-Cel… Lymphoma, T-Cel… Lymphoma, T-Cel… Cutaneous T-Cel…
-
-
NCT00187746
Details
2012-11-21
Interventional
40 
Adefovir Adefovir dipivo…
Other Condition…
Budget exceeded for project.
-
NCT01288079
Details
2012-11-20
Interventional
2145 
Duloxetine Hydr…
Depression Depressive Diso… Depressive Diso… Major Depressiv…
-
The study was terminated early and thus only a fraction of the planned number of patients were randomized and many did not complete the study. As a consequence the possibility of interpreting efficacy over an 8 week period is considerably reduced.
NCT01177501
Details
2012-11-19
Interventional
13 
Topotecan
Carcinoma, Ovar… Ovarian Neoplas… Ovarian Cancer Relapses
choice of the principal investigator
-
NCT00545298
Details
2012-11-19
Interventional
24 
Nitric Oxide
Leg Ulcer Ulcer Varicose Ulcer Venous Ulcers
Strategic direction of the sponsor changed
Early termination due to small number of subjects enrolled
NCT00713011
Details
2012-11-16
Interventional
30 
Nifedipine
Diabetic Nephro… Hypertension Proteinuria
Study was stopped by sponsor prior to first patient assignment to groups due to operational reasons.
-
NCT00674999
Details
2012-11-15
Interventional
2/30 
Bacitracin Nystatin
Burns Burn
Hurricane- terminated study due to skin bank being destroyed
-
NCT00591604
Details
2012-11-15
Interventional
30 
Vitamin D
Burns Vitamin D Defic… Burn
hurricane caused closure of hospital with PI not associated with Shriners Hospital for children
-
NCT00762190
Details
2012-11-12
Interventional
3348 
Insulin Insulin, Globin…
Diabetes Mellit… Diabetes Mellit…
Hepatic safety signal identified.
-
NCT00074607
NCT00039143
NCT00048243
NCT00052806
Details
2012-11-12
Interventional
1
[1 Refs]
10 
Gemcitabine
Meningeal Carci… Meningitis Neoplasms
-
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