Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02603068
Details
2016-02-09
Interventional
20 
Treprostinil
Fibrosis Hypertension Hypertension, P… Pulmonary Fibro… Pulmonary Hyper…
Study design was inadequate and would not achieve study endpoints
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NCT01697072
2011-004923-11
Details
2016-02-09
Interventional
3609 
Capecitabine Cisplatin Epirubicin Rilotumumab
Adenocarcinoma Stomach Neoplas… Gastric Cancer
All Amgen sponsored AMG102 clinical studies were terminated following a pre-planned Data Monitoring Committee safety review of study 20070622.
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NCT01604031
Details
2016-02-08
Interventional
12 
Lenalidomide
Leukemia, Lymph… B-cell Chronic …
-
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NCT01367210
2010-023316-13
Details
2016-02-08
Interventional
4165 
Anti-Retroviral… Darunavir Maraviroc
HIV Infections HIV Infection
Because a higher rate of virological failures in study versus control arm.
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NCT01161498
Details
2016-02-08
Interventional
35 
Talimogene lahe…
Carcinoma Carcinoma, Squa… Head and Neck N… Head and Neck C… Squamous Cell C…
The changing aetiology of squamous cell carcinoma of the head and neck (SCCHN).
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NCT01122927
Details
2016-02-08
Interventional
3524 
Aripiprazole
Bipolar Disorde… Mental Disorder… Psychotic Disor… Schizophrenia Adolescent Schi… Child or Adoles…
The trial was terminated early as the objective of the Aripiprazole Pediatric Investigational Plan was met and provided 2 years of safety data.
The study was terminated by the Sponsor as the European Medicines Agency P/99/2011Aripiprazole PIP which directed the sponsor to provide 2 years of safety data for at least 100 participants. The objective was met in April 2014.
NCT00177255
Details
2016-02-08
Interventional
240 
Capecitabine Docetaxel
Cancer
Roche has withdrawn support
-
NCT02288208
Details
2016-02-05
Interventional
17 
Antiviral Agent… Entecavir Tenofovir
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch…
Due to cranial nerve palsies observed
-
NCT01844700
Details
2016-02-05
Interventional
414 
Aripiprazole Quetiapine Fuma… Risperidone Ziprasidone
Weight Gain High Risk MC4R … Low Risk MC4R G… One Week or Les…
very slow recruitment, no sufficient results
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NCT01204138
Details
2016-02-05
Interventional
20 
Apremilast
Arthritis, Rheu…
decision of sponsor to withdraw before initiation; 0 patients enrolled
-
NCT00361257
Details
2016-02-05
Interventional
2
[2 Refs]
107 
Minocycline Tetracycline
HIV Infections
This study was terminated early due to futility.
Originally, 100 participants were expected to enroll. As of the early termination notice, 107 participants were randomized, yet not all subjects could complete the 24 week assessment.
NCT01324544
2010-021955-14
Details
2016-02-04
Interventional
30 
Buprenorphine
Pain, Postopera… Other Acute Pos… Prolonged Endot…
Due to change in development plan.
-
NCT01029444
Details
2016-02-03
Interventional
3300 
Insulin Aspart
Diabetes Mellit…
Administrative
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NCT02309450
2014-002724-27
Details
2016-02-02
Interventional
20 
Asunaprevir
Hepatitis C Hepatitis C Vir…
BMS decision
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NCT02131506
2009-012996-82
Details
2016-02-02
Interventional
111 
Doxorubicin Lapatinib Liposomal doxor…
Breast Neoplasm… Neoplasms HER-2 Positive … Malignant Neopl…
Safety reasons
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NCT02483624
Details
2016-02-01
Interventional
16 
3,3'-diindolylm…
Lupus Erythemat… SLE
-
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NCT01515813
Details
2016-02-01
Interventional
20 
Efavirenz Efavirenz, Emtr… Emtricitabine Emtricitabine, … Pravastatin Tenofovir
Inflammation HIV-1 Infection
On 05/08/12, team working on revising protocol and re-open study under version 2.0
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NCT01786395
Details
2016-01-29
Interventional
3202 
Isopropyl unopr…
Retinitis Retinitis Pigme…
-
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NCT00409591
Details
2016-01-28
Interventional
3
[2 Refs]
435 
Lopinavir Nevirapine Ritonavir Zidovudine
HIV Infections Pregnancy
Change in National PMTCT guidelines in Thailand
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NCT00831441
2008-008298-77
Details
2016-01-27
Interventional
37484 
Apixaban
Acute Coronary … Syndrome
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