Trials Annotator

Trial NCT00361257

View at ClinicalTrials.gov

Org. Study IDs: ACTG A5235
Secondary IDs: 1U01AI068636

Last trial update was posted on 2016-02-05

MeSH Interventions

Minocycline Tetracycline

MeSH Conditions

HIV Infections

Other Conditions

Stopping Reasons

This study was terminated early due to futility.

Limitations And Caveats

Originally, 100 participants were expected to enroll. As of the early termination notice, 107 participants were randomized, yet not all subjects could complete the 24 week assessment.

Result Publications

Sacktor N, Miyahara S, Deng L, Evans S, Schifitto G, Cohen BA, Paul R, Robertson K, Jarocki B, Scarsi K, Coombs RW, Zink MC, Nath A, Smith E, Ellis RJ, Singer E, Weihe J, McCarthy S, Hosey L, Clifford DB; ACTG A5235 team. Minocycline treatment for HIV-associated cognitive impairment: results from a randomized trial. Neurology. 2011 Sep 20;77(12):1135-42. doi: 10.1212/WNL.0b013e31822f0412. Epub 2011 Sep 7. [PMID: 21900636] [DOI: 10.1212/WNL.0b013e31822f0412]
Sacktor N, Miyahara S, Evans S, Schifitto G, Cohen B, Haughey N, Drewes JL, Graham D, Zink MC, Anderson C, Nath A, Pardo CA, McCarthy S, Hosey L, Clifford D; ACTG A5235 team. Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment. J Neurovirol. 2014 Dec;20(6):620-6. doi: 10.1007/s13365-014-0292-0. Epub 2014 Nov 7. [PMID: 25377444] [DOI: 10.1007/s13365-014-0292-0]

Annotations

Category Annotations

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Intervention Annotations

#	Outdated	Intervention				Condition
#	Outdated	Name		Route	DrugBank ID	Condition