Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00954512
2009-011101-16
Details
2018-08-24
Interventional
1/215 
Carboplatin Cetuximab Epirubicin Everolimus Folic Acid Gemcitabine Irinotecan Leucovorin Levoleucovorin Trastuzumab
Neoplasms
This study was terminated for business reasons.
-
NCT02663752
Details
2018-08-23
Interventional
21 
Deferasirox
Myelodysplastic… Preleukemia Syndrome Myelodysplastic…
-
The trial was terminated due to low enrollment.
NCT02329756
Details
2018-08-23
Interventional
30 
Tranexamic Acid
Placenta Accret…
More preparation needed prior to collecting data.
-
NCT00847223
Details
2018-08-23
Interventional
211 
Tipifarnib
Lymphoma Lymphoma, Mantl… Mantle Cell Lym…
Inefficiency of treatment
-
NCT00617890
Details
2018-08-23
Interventional
2
[1 Refs]
219 
Antibodies, Mon…
Neuroectodermal… Neuroectodermal… Neuroectodermal… Osteosarcoma Sarcoma Sarcoma, Ewing Peripheral Neur… Sarcoma, Ewing'…
The study was prematurely terminated for strategic reasons, not for a safety concern.
The study was stopped prematurely for administrative reasons; not all planned endpoints were analyzed.
NCT00300573
2006-000096-16
Details
2018-08-23
Interventional
2250 
Dexelvucitabine
Acquired Immuno… HIV Infections Human Immunodef…
Development program ended due to inability to pair with other cytidine analogs and higher risk of hyperlipasemia when not used with 3TC/FTC.
-
NCT02632903
Details
2018-08-22
Interventional
20 
Zoledronic Acid
Leukemia Osteonecrosis Osteoporosis Precursor Cell … Acute Lymphobla…
While the clinical need for and the scientific merit remain valid, this regulated drug trial was not feasible logistically due to limited funds.
-
NCT01847014
Details
2018-08-22
Interventional
34 
Macitentan
Familial Primar… Hypertension Pulmonary Arter…
Protocol-defined criterion of macitentan availability achieved.
-
NCT00930241
Details
2018-08-22
Interventional
325 
Tacrolimus
Lung Transplant…
logistic reasons (insufficient funding, technical problems with MEMS)
-
NCT02770729
Details
2018-08-21
Interventional
33640 
Moxifloxacin Norgestimate, e…
Endophthalmitis
-
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NCT02762617
Details
2018-08-21
Interventional
1
[1 Refs]
17 
Tenofovir
HIV Healthy
Safety-related
-
NCT01425996
Details
2018-08-21
Interventional
1/23 
Camptothecin
Carcinoma Carcinoma, Hepa…
-
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NCT00415857
Details
2018-08-21
Interventional
25 
Imatinib Mesyla… Peginterferon a… Sargramostim Vaccines
Leukemia
Vaccine sponsor ceased operations.
-
NCT02684084
Details
2018-08-20
Interventional
45 
Dexamethasone Ranibizumab
Edema Macular Edema Diabetic Macula…
Study revised significantly. New trial to be launched.
-
NCT02386098
Details
2018-08-20
Interventional
286 
Atazanavir Sulf… BMS-955176 Dolutegravir Ritonavir Tenofovir
HIV Infections
GI Intolerability
-
NCT01695759
Details
2018-08-20
Interventional
392 
Epoetin Alfa
Anemia Kidney Diseases Renal Insuffici… Chronic Kidney …
-
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NCT01673490
Details
2018-08-20
Interventional
459 
Dutasteride Tamsulosin
Hyperplasia Prostatic Hyper…
The sole investigative site refused to accept the amended protocol and declined to continue the study. There was no safety signal nor any other reason.
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NCT00688597
Details
2018-08-17
Interventional
23 
1-Deoxynojirimy…
Glycogen Storag… Pompe Disease
Per protocol, 3 sequential dose cohorts were planned. Study discontinued by Sponsor based upon serious adverse events in first 2 of 3 participants in Cohort 1.
The serious adverse event of muscle weakness was the main contributor to the study not reaching the target number of participants needed to achieve target power and statistically reliable results.
NCT03285607
Details
2018-08-16
Interventional
10 
Cyclophosphamid… Doxorubicin Paclitaxel
Breast Neoplasm… Breast Cancer Cancer of Breas…
Drug provider decided not to move forward with the study.
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NCT01943019
Details
2018-08-16
Interventional
11 
Linagliptin
Schizophrenia
Inability to obtain patients
-