Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04238091
Details
2022-03-21
Interventional
20 
Anti-Bacterial …
Alopecia Alopecia Areata Alopecia Totali… Alopecia Univer…
Investigator is no longer interested in moving forward with this study
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NCT02999633
2016-002739-14
Details
2022-03-21
Interventional
214 
Acetaminophen BB 1101 Dexamethasone Dexamethasone a… Diphenhydramine Promethazine Ranitidine Ranitidine bism…
Leukemia Leukemia, Lymph… Lymphoma Precursor Cell … Precursor T-Cel… T-cell Type Acu… T-lymphoblastic…
Due to an unsatisfactory benefit/risk ratio, as specified in & 14.8.1 of the protocol, Sanofi decided to stop enrollment and terminate ACT14596 prematurely
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NCT02654314
Details
2022-03-21
Interventional
3277 
Melatonin
Delirium
Lack of resources to complete the study. Descriptive statistics for the outcome measures collected are provided.
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NCT04656691
Details
2022-03-18
Interventional
4139 
Bamlanivimab
COVID-19 Covid19
In April 2021 FDA revoked the Emergency Use Authorization after determining that the known and potential benefits of bamlanivimab, when administered alone, no longer outweigh the known and potential risks for its authorized use.
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NCT04555096
Details
2022-03-18
Interventional
216 
Avasopasem mang…
COVID-19 Critical Illnes… Infections Covid19 SARS-CoV-2 Infe…
Participants are no longer receiving intervention
Study was terminated early due to the inability to enroll critically ill COVID 19 patients as the height of the pandemic was over and the sites that were open for enrollment to the clinical study were no longer treating these types of patients.
NCT01388920
Details
2022-03-18
Interventional
23 
Tesamorelin
Cachexia Lung Diseases Lung Diseases, … Muscular Atroph… Pulmonary Disea… Wasting Syndrom… Chronic Obstruc…
The study was terminated based on a non-safety related corporate decision.
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NCT03735290
Details
2022-03-16
Interventional
121 
Pembrolizumab
Adenocarcinoma Carcinoma, Squa… Squamous Cell C… Carcinoma, Squa… Gastric Adenoca… Gastroesophagea… Non-small Cell …
Decision made not to move to Phase 2
-
NCT02932579
Details
2022-03-16
Interventional
459 
Acetaminophen Ibuprofen Oxycodone
Toothache Pain
Study was halted permanently due to enrollment and logistic issues.
-
NCT01452152
Details
2022-03-16
Interventional
49 
Clopidogrel Prasugrel Hydro…
Acute Coronary … Cardiovascular …
Terminated by study sponsor.
The study was terminated early by the sponsor due to low enrollment.
NCT05254808
Details
2022-03-15
Interventional
313 
Fosfomycin Nitrofurantoin
Cystitis Urinary Tract I…
Insufficient participating sites, and insufficient participants from participating sites mainly due to COVID-19 workload. The number of necessary participants could not be reached within the anticipated timelines and the allocated budget.
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NCT04441385
2020-002011-21
Details
2022-03-11
Interventional
260 
Maraviroc
COVID-19
lack of viability
-
NCT02356458
2014-003893-17
Details
2022-03-11
Interventional
1/258 
Bortezomib Ibrutinib
Lymphoma Lymphoma, Mantl… Mantle Cell Lym…
SAKK Board decision of 14th November 2020 due to financial reasons.
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NCT05051150
Details
2022-03-10
Interventional
418 
Epinephrine Epinephryl bora… Racepinephrine
Hypotension Cesarean Sectio… Post-spinal Hyp…
tachycardia and arrhythmia in the high doses groups 0.05 and 0.07 necessitate stopping the infusion
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NCT04990778
Details
2022-03-10
Interventional
20 
Venetoclax
Lymphoma Lymphoma, Mantl… Recurrent Mantl… Refractory Mant…
PI Request
-
NCT04324021
2020-001167-93
Details
2022-03-10
Interventional
2/316 
Interleukin 1 R…
Infections SARS-CoV-2
Standard of care evolved during the timeframe of the study and had critical impact on recruitment. Early termination was not based on safety reasons but due to the reasons mentoined above. The ongoing patients were completed.
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NCT04209621
Details
2022-03-09
Interventional
23 
Ibrutinib
Leukemia Leukemia, Lymph… Leukemia, Lymph… Chronic Lymphoc… Small Lymphocyt…
Due to unexpected sudden death on study.
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NCT03592407
Details
2022-03-08
Interventional
20 
Pembrolizumab
Adenocarcinoma Esophageal Squa… Esophageal Aden… Gastroesophagea…
Safety concerns
-
NCT05267977
Details
2022-03-07
Interventional
1/2-
Cephalosporins First Generatio…
Fractures, Bone Fractures, Open Lower Extremity…
-
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NCT03549650
Details
2022-03-04
Interventional
23 
Pentosan Sulfur…
Lower Urinary T… Urinary Bladder… BCG Bladder Carcino…
Given the updated precautions on Elmiron as well as the risk benefit profile, we have decided to terminate the study.
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NCT02570503
Details
2022-03-04
Interventional
464 
Clonidine Epinephrine Ketorolac Ropivacaine
Osteoarthritis,… Pain, Postopera…
Study's primary aims are no longer clinically impactful, as intrathecal morphine has fallen out of favor and replaced with different agents so that outpatient/23 hr surgery is more predictably achievable.
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