Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04005079
Details
2022-04-07
Interventional
30 
Ofloxacin Pilocarpine Prednisolone
Cataract Glaucoma Glaucoma, Open-… Ocular Hyperten… Open Angle Glau…
not performing Trabectomes
-
NCT03809234
Details
2022-04-07
Interventional
114 
Ondansetron
Neuralgia Neuropathic Pai…
Adverse effects related to study procedure (not study drug)
-
NCT03684785
Details
2022-04-07
Interventional
1/257 
Cemiplimab Pembrolizumab
Carcinoma Carcinoma, Merk… Carcinoma, Squa… Melanoma Squamous Cell C… Advanced or Met… Advanced or Met… Advanced or Met… Advanced or Met… Advanced or Met…
The study was canceled for administrative reasons.
-
NCT02850419
Details
2022-04-07
Interventional
20 
Doxorubicin Liposomal doxor…
Breast Neoplasm… Breast Cancer
Administrative
-
NCT04660045
Details
2022-04-05
Interventional
20 
Acalabrutinib
Leukemia, Lymph… CLL/SLL Chronic Lymphoc…
Company supplying drug/funding ceased support.
-
NCT04607252
Details
2022-04-05
Interventional
2/312 
Megestrol Megestrol Aceta… Metformin
Endometrial Hyp… Hyperplasia Atypical Endome…
Our clinical trial NCT03241888 showed LNG-IUS had a better treatment efficacy than Megestrol Acetate (MA) alone. The median CR time for MA group, LNG-IUS group and MA plus LNG-IUS group was 7.0±0.3 months, 4.4±1.0 months and 5.7±1.2 months.
-
NCT03685253
Details
2022-04-05
Interventional
1/2-
Niacinamide
Diabetic Neurop… Peripheral Nerv… Diabetic Neurop…
pilot component of study completed
-
NCT03217838
Details
2022-04-05
Interventional
150 
Azacitidine Pyrazole Venetoclax
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
strategic decision
-
NCT04787250
Details
2022-04-04
Interventional
1/20 
Anti-Bacterial … Antibiotics, An…
Arthritis, Infe… Communicable Di… Infections Prosthetic Join…
Changes to protocol design
-
NCT03924245
Details
2022-04-04
Interventional
13 
Entinostat Olaparib
Adenocarcinoma Adenocarcinoma,… Carcinoma Carcinoma, Endo… Carcinosarcoma Cystadenocarcin… Endometrial Neo… Fallopian Tube … Mixed Tumor, Mu… Recurrence Fallopian Tube … Fallopian Tube … Fallopian Tube … Fallopian Tube … High Grade Fall… High Grade Ovar… Ovarian Carcino… Ovarian Clear C… Ovarian Endomet… Primary Periton… Recurrent Endom… Recurrent Ovari… Recurrent Prima…
Change in participant landscape and other treatment availability
-
NCT03559010
Details
2022-04-04
Interventional
3189 
Norgestrel
Contraception
Terminated prematurely due to issues with one of the data collection systems, no impact on subject safety
-
NCT03008616
Details
2022-04-04
Interventional
2/359 
Digoxin
Pre-Eclampsia Severe Preeclam…
Following a recommendation from the Data and Safety Monitoring Board (DSMB), the study was stopped early for futility. There were no safety concerns raised.
-
NCT02824575
Details
2022-04-04
Interventional
128 
Paclitaxel Rebastinib
Breast Neoplasm… Carcinoma Breast Adenocar… Breast Cancer Human Epidermal… Recurrent Breas… Stage IV Breast…
Unfortunately, Deciphera management decided to not move forward with the rebastinib program and are terminating early.
-
NCT02420795
Details
2022-04-04
Interventional
1/216 
TIC10 compound
Lymphoma Lymphoma, Mantl… Lymphoma, Non-H… Recurrence Central Nervous… Gastric Mantle … Recurrent Mantl… Recurrent Non-H… Refractory Mant… Refractory Non-… Splenic Mantle …
Per PI Request
-
NCT01155375
Details
2022-04-04
Interventional
314 
Ferrosoferric O… Ferrous fumarat…
Anemia Anemia, Iron-De… Deficiency Dise… Iron Deficienci… Kidney Diseases Renal Insuffici… Iron Deficiency…
Several factors contributed to significant challenges in enrollment and led the Sponsor to discontinue the AMAG-FER-CKD-251 study as designed.
While sample data were collected, it was not run through any analysis to obtain the necessary outcome measure data. As such, summary of the data set is not possible.
NCT00785798
Details
2022-04-04
Interventional
1/217 
Doxorubicin Liposomal doxor… Vorinostat
Lymphoma Refractory Lymp… Relapsed Lympho…
sponsor requested
-
NCT04561076
Details
2022-04-01
Interventional
10 
Myeloma Protein… Paraproteins
COVID 19
Sponsor strategy
-
NCT04037241
Details
2022-04-01
Interventional
2/30 
Capecitabine Gemcitabine Leucovorin Paclitaxel
Pancreatic Neop… Malignant Tumor…
Sponsor terminated
-
NCT03418805
Details
2022-04-01
Interventional
131 
Ibuprofen
Pain Control
Sponsor's consideration of product development strategies
-
NCT04301310
Details
2022-03-31
Interventional
10 
Rifampin
Healthy Partici…
Business objectives have changed
-