Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04387240
Details
2022-05-02
Interventional
20 
Artemisinin Artemisinins Artesunate
COVID-19 Coronavirus Inf… Corona Virus In… Covid 19 Positi…
did not get enough fund and IRB request
-
NCT04331717
Details
2022-05-02
Interventional
20 
Leuprolide
Obesity, Morbid Prostate Adenoc…
accrual on hold
-
NCT03320642
Details
2022-05-02
Interventional
184 
Calcineurin Inh…
Graft vs Host D… Hematologic Neo… Hematologic Mal…
Study terminated by sponsor
-
NCT01608451
Details
2022-05-02
Interventional
3800 
Cholecalciferol Progesterone Vitamin D
Breast Neoplasm… Locally Advance…
Slow accrual implies that clinical questions being questioned have lost its significance.
-
NCT04042727
Details
2022-04-29
Interventional
2/313 
Dexmedetomidine
Atrial Fibrilla… Heart Rate Cont… Rapid Atrial Fi…
Futility, as a result of CIVID-19 impact
-
NCT02940548
Details
2022-04-29
Interventional
499 
Amlodipine Nifedipine
Hypertension
The patient recruitment and follow-ups were influenced with the pandemic of COVID-19
-
NCT00358163
Details
2022-04-29
Interventional
17 
Paclitaxel Vatalanib
Neoplasms Metastatic Non-…
-
-
NCT02711137
Details
2022-04-28
Interventional
1/2137 
Azacitidine Gemcitabine INCB057643 Paclitaxel Rucaparib
Neoplasms Solid Tumors
Study terminated due to safety issues.
-
NCT01264679
Details
2022-04-28
Interventional
38 
Ferrosoferric O…
Anemia Anemia, Iron-De… Deficiency Dise… Iron Deficienci… Kidney Diseases Renal Insuffici… Iron Deficiency…
Several factors contributed to significant challenges in enrollment and led the Sponsor to discontinue the AMAG-FER-CKD-253 study as designed.
While sample data were collected, it was not run through any analysis to obtain the necessary outcome measure data. As such, summary of the data set is not possible.
NCT01155388
Details
2022-04-28
Interventional
314 
Ferrosoferric O… Ferrous fumarat…
Anemia Anemia, Iron-De… Deficiency Dise… Iron Deficienci… Kidney Diseases Renal Insuffici… Iron Deficiency… Nondialysis-dep…
Several factors contributed to significant challenges in enrollment and led the Sponsor to discontinue the AMAG-FER-CKD-252 study as designed.
While sample data were collected, it was not run through any analysis to obtain the necessary outcome measure data. As such, summary of the data set is not possible.
NCT03254732
Details
2022-04-27
Interventional
133 
Pembrolizumab
Advanced Solid …
Changing Corporate Priorities
-
NCT02154529
Details
2022-04-27
Interventional
1/217 
Trastuzumab XL647
Breast Neoplasm… Neoplasms HER-2 Positive … Metastatic Mali…
Sponsor closed the study due to lack of response.
-
NCT00707213
Details
2022-04-27
Interventional
119 
Deoxyglucose
Febrile Neutrop… Neutropenia Cancer
Funding from the NIH ended and not all patients had been accrued
-
NCT03172897
Details
2022-04-26
Interventional
4-
Dexmedetomidine
Delirium Adult Disease Dexmedetomidine Intensive Care … Mechanical Vent…
The trial was stopped because of difficulty in recruiting patients (another trial had similar inclusion/exclusion criteria). No patients was recruited in this trial.
-
NCT04371393
Details
2022-04-25
Interventional
3223 
Remestemcel-l
Acute Lung Inju… Respiratory Dis… Respiratory Dis… Syndrome Acute Respirato… COVID Mesenchymal Str… Remestemcel-L
At 3d interim analysis, randomization, but not follow-up, was halted by the DSMB due to low predictive probability of achieving postulated mortality benefit (pre-specified 42.5% relative mortality reduction) were the trial to complete randomization.
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NCT04003818
Details
2022-04-25
Interventional
450 
Teicoplanin
Clostridium Inf… Colitis Diarrhea Infections Clostridium Dif…
Due to COVID-19 and great challenges during patient enrolment period, current status of this study is far behind the plan. The study cannot be completed according to the plan. Sanofi decides to terminate the study upon comprehensive assessment.
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NCT03761134
Details
2022-04-25
Interventional
3377 
(2S,3R,4R,5S,6R… Metformin
Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes…
Sanofi ended collaboration with Lexicon for Sotagliflozin. In China no regulatory pathway to transfer sponsorship during the conduct of ongoing studies.
-
NCT03760965
Details
2022-04-25
Interventional
3276 
(2S,3R,4R,5S,6R…
Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes…
Sanofi ended collaboration with Lexicon for Sotagliflozin. In China no regulatory pathway to transfer sponsorship during the conduct of ongoing studies.
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NCT03630809
Details
2022-04-25
Interventional
216 
Vaccines
Breast Neoplasm… Breast Neoplasm… Breast Cancer Breast Cancer F… Breast Cancer, … HER-2 Gene Ampl… HER-2 Protein O… HER2 Positive B… HER2-positive B…
Quality of the data originating from prior versions of the protocol has been affected by protocol deviations triggered by the COVID-19 pandemics
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NCT03555968
Details
2022-04-25
Interventional
40 
Dronabinol
Alcohol Drinkin… Accident, Traff… Cannabis
Logistical issues
-