Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02322099
Details
2022-05-26
Interventional
453 
Alendronate Calcium Calcium Carbona… Cholecalciferol Tenofovir Vitamin D
Bone Deminerali… Bone Deminerali…
Due to the COVID-19 pandemic the study was terminated prematurely
-
NCT02003742
Details
2022-05-26
Interventional
3104 
Tamsulosin
Lower Urinary T…
The study was stopped because in two other clinical studies the drug was not superior in comparison with placebo
-
NCT01369199
NCT01534611
Details
2022-05-26
Interventional
328 
Entecavir Peginterferon a…
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch…
-
Early termination of recruitment per Data and Safety Monitoring Board. 1 case with multiple central and local lab discrepancies was not considered to have HBeAg loss since central lab was always negative.
NCT04676243
Details
2022-05-25
Interventional
30 
Quizartinib
Acute Myeloid L…
Study turned out no longer feasible
-
NCT04400799
Details
2022-05-25
Interventional
3475 
Enoxaparin
COVID-19 Embolism Pulmonary Embol… Thrombosis Venous Thrombos… Pulmonary Embol…
due to results from interim analysis
-
NCT03845322
Details
2022-05-25
Interventional
1
[1 Refs]
0 
Curcumin
Hematoma Hematoma, Subdu… Hematoma, Subdu… Recurrence
12 Screen failures and Changes in PI and loss of residency program.
-
NCT02616055
Details
2022-05-25
Interventional
215 
XL647
Kidney Diseases Polycystic Kidn… Polycystic Kidn… Autosomal Domin…
Sponsor opened Phase 2 Study.
-
NCT03378466
Details
2022-05-24
Interventional
2178 
Calcium heparin Heparin
Shock Shock, Septic Septic Shock Vasodilatory Sh…
infeasible to continue due-to inability to recruit during the COVID-19 pandemic and grants coming to an end.
-
NCT02999854
2016-004672-21
Details
2022-05-24
Interventional
363 
Cyclophosphamid…
Leukemia Myelodysplastic… Precursor Cell … Acute Lymphobla… Acute Myeloid L… Myelodysplastic…
Insufficient efficacy, terminated by Sponsor
-
NCT02906020
2016-000657-12
Details
2022-05-24
Interventional
2273 
Venglustat
Parkinson Disea… Parkinson's Dis…
The topline results of the 52-week double-blind placebo-controlled period were analyzed. The study did not meet the primary or secondary endpoints. Based on these results, the decision was made to halt the long-term follow-up period of the study
This study did not achieve its primary or secondary endpoints at the time of the analysis of the double-blind 52-week treatment period of Part 2 and was terminated early.
NCT02783404
Details
2022-05-24
Interventional
4
[4 Refs]
40 
Amoxicillin Clavulanic Acid Clavulanic Acid…
Bacteremia Endocarditis Bacteraemia
Significant results (no control neither amoxicillin new arms needed)
-
NCT02113176
Details
2022-05-24
Interventional
1/20 
Minocycline
Aneurysm Hemorrhage Subarachnoid An…
Funding of minocycline
-
NCT03444753
Details
2022-05-23
Interventional
182 
Ipilimumab Nivolumab
Advanced Cancer
business objectives have changed
-
NCT02449161
Details
2022-05-23
Interventional
360 
Medroxyprogeste…
Amenorrhea Menorrhagia
Missing fund to continue
-
NCT05292976
Details
2022-05-20
Interventional
30 
Albuterol Methacholine Ch…
Asthma Bronchial Asthm…
Business reasons
-
NCT04264806
2019-003576-40
Details
2022-05-20
Interventional
20 
Azacitidine
Leukemia Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Preleukemia Syndrome
The cusatuzumab MDS strategy is under revision
-
NCT03552029
Details
2022-05-20
Interventional
110 
Quizartinib
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
This study was terminated based on a business decision by the Sponsor.
This study was terminated based on a business decision by the Sponsor and was not due to a safety concern.
NCT03363503
Details
2022-05-20
Interventional
464 
Fluticasone Salmeterol Xina… Xhance
Respiratory Asp… COPD
Adequate number of patients could not be reached in the relevant centers.
-
NCT03332589
Details
2022-05-20
Interventional
14 
Dabrafenib
Brain Neoplasms Melanoma Neoplasm Metast… Brain Metastase… Malignant Melan…
Single center study: Principal Investigator left institution.
Due to the departure of the study PI from the institution, the study was terminated early.
NCT02953145
Details
2022-05-20
Interventional
40 
Fibrin Tissue A…
Cleft Palate Pain, Postopera…
Lack of support
-