Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT05148195
Details
2024-03-13
Interventional
286 
Calcium Docetaxel Irinotecan Leucovorin Levoleucovorin
Neoplasms Advanced Solid …
The study was terminated due to the sponsor's research and development strategy adjustment.
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NCT04761601
Details
2024-03-13
Interventional
132 
Gemcitabine Paclitaxel
Neoplasms Advanced Solid …
Stopped for strategic business reasons. The decision to stop the study was not connected to any safety concerns, or new risk associated with the study product, intervention, or procedures.
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NCT04612725
2020-000169-17
Details
2024-03-13
Interventional
2159 
Benralizumab
Chronic Urticar… Urticaria Chronic Spontan…
Study did not meet primary endpoint
The study was terminated early by the sponsor as the primary analysis results did not support the continued development of benralizumab for the indication of CSU.
NCT04529954
Details
2024-03-13
Interventional
1/220 
Valproic Acid
Epilepsies, Par… Epilepsy Focal Epilepsy
Company Decision
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NCT04197986
2019-003248-63
Details
2024-03-13
Interventional
339 
Infigratinib
Carcinoma Carcinoma, Tran… Urinary Bladder… Upper Tract Uro… Urothelial Blad…
The sponsor has decided to close the study due to the discontinuation of infigratinib development. The discontinuation of the study was not due to safety reasons.
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NCT04172597
Details
2024-03-13
Interventional
21 
Antidiarrheals Loperamide
Breast Neoplasm… Breast Cancer Colorectal Canc… Glioblastome Mu… Solid Tumor
Strategic business decision (unrelated to safety)
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NCT04060849
Details
2024-03-13
Interventional
1-
Ethanol Pharmaceutical …
Neoplasms Hematopoietic a… Malignant Solid… Solid Neoplasm
Enrollment temporarily on hold, pending protocol and study document updates
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NCT03533946
Details
2024-03-13
Interventional
27 
Rucaparib
Prostatic Neopl… Prostate Cancer
New standard of care for study participant population
-
NCT02923739
Details
2024-03-13
Interventional
29 
Albumin-Bound P… Antibodies Antibodies, Mon… Antineoplastic … Bevacizumab Endothelial Gro… Immunoglobulin … Immunoglobulins Paclitaxel
Adenocarcinoma Adenocarcinoma,… Adenocarcinoma,… Brenner Tumor Carcinoma Carcinoma, Endo… Carcinoma, Tran… Cystadenocarcin… Cystadenocarcin… Recurrence Fallopian Tube … Fallopian Tube … Fallopian Tube … Fallopian Tube … Fallopian Tube … Fallopian Tube … Fallopian Tube … Malignant Ovari… Ovarian Adenoca… Ovarian Clear C… Ovarian Endomet… Ovarian Mucinou… Ovarian Seromuc… Ovarian Serous … Ovarian Transit… Ovarian Undiffe… Primary Periton… Recurrent Fallo… Recurrent Ovari… Recurrent Prima…
The study was terminated early by the Sponsor
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NCT02574910
Details
2024-03-13
Interventional
1-
Abiraterone Ace…
Adrenal Hyperpl… Adrenocortical … Adrenogenital S… Hyperplasia Congenital Adre…
Need to update IND
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NCT02451111
2015-001487-19
Details
2024-03-13
Interventional
2190 
Ibrutinib Rituximab
Lymphoma Lymphoma, Folli… Follicular Lymp…
The premature termination is based on the decision by the SAKK board on November 14, 2020 due to the lack of further financial support for the follow up period.
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NCT02230930
Details
2024-03-13
Interventional
213 
Apomorphine Hydrocortisone Hydrocortisone … Hydrocortisone … Hydrocortisone …
Parkinson Disea… Apomorphine-ind… Parkinson's Dis…
Delayed inclusion - stopped when 10 patients completed the study
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NCT06036511
Details
2024-03-12
Interventional
1/20 
Ketamine
Stress Disorder… PTSD
Per PI, this trial will not be started at UNM due to change in institutional responsibilities of the PI
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NCT05979415
Details
2024-03-12
Interventional
28 
Apomorphine
Parkinson Disea…
Administrative decision
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NCT05085002
Details
2024-03-12
Interventional
2100 
Fulvestrant Letrozole
Breast Neoplasm… Advanced Breast…
The study is being closed based on corporate changes at EQRx and is not related to any efficacy or safety issues with lerociclib.
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NCT04933227
Details
2024-03-12
Interventional
229 
Atezolizumab Capecitabine Oxaliplatin
Adenocarcinoma Stomach Neoplas… Gastric Cancer Gastroesophagea…
Sponsor's decision to terminate the study after Stage 1; will not proceed with Stage 2.
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NCT04137978
Details
2024-03-12
Interventional
2/30 
Potassium Citra…
Cystinuria
Unspecified business decision/strategic reason
-
NCT04102436
Details
2024-03-12
Interventional
20 
Aldesleukin Cyclophosphamid… Fludarabine
Urogenital Neop… Breast Cancer Endocrine/Neuro… Gastrointestina… Non-Small Cell … Ovarian Cancer
Difficulty with availability of GLP-grade reagents for manufacturing.
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NCT04014361
Details
2024-03-12
Interventional
136 
Itraconazole
Healthy
HUAA study is terminated early due to a business decision.
A strategic business decision was made to terminate the study prior to initiation of the multiple-ascending dose study (Part C). The secondary objectives pertaining to Part D were not evaluated as the study was terminated before the commencement of Part D.
NCT03982992
2017-002314-31
Details
2024-03-12
Interventional
20 
Blinatumomab
Leukemia Leukemia, Lymph… Neoplasm, Resid… Precursor Cell … Acute Lymphobla… Acute Lymphobla… Acute Lymphobla… B Cell Precurso… B-Cell Acute Ly…
Lack of potential study subjects due to a change of standard of care treatment outside of clinical trials.
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