Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01397162
2010-023167-17
Details
2022-06-23
Interventional
229 
Fluticasone Xhance
Asthma
-
Study was terminated by the decision of the sponsor. As limited data were collected due to early termination and only limited number of patients completed the 8-week treatment period, no analyses of primary and secondary endpoints were conducted.
NCT01396278
2010-023169-23
Details
2022-06-23
Interventional
29 
Fluticasone Xhance
Asthma
-
Study was terminated by the decision of sponsor. As limited data were collected due to early termination and only limited number of patients completing the 8-week treatment period, no analyses of primary and secondary endpoints were conducted.
NCT00573131
Details
2022-06-22
Interventional
2137 
Cisplatin Paclitaxel
Carcinoma, Squa… Esophageal Neop… Adenocarcinoma … Esophageal Canc… Squamous Cell C…
OncoGel did not show any impact on overall tumor response
Study prematurely terminated due to lack of efficacy in primary endpoint.
NCT00479765
Details
2022-06-22
Interventional
1/24 
Paclitaxel
Brain Neoplasms Glioblastoma Glioma Glioblastoma Mu…
Sponsor business decision, not based on safety or efficacy data
-
NCT04609397
Details
2022-06-21
Interventional
289 
Hemay005
Behcet Syndrome Behçet Disease
The study purpose has been achieved
-
NCT04341441
Details
2022-06-21
Interventional
3624 
Hydroxychloroqu…
COVID-19 Coronavirus Inf… Coronavirus SARS-CoV 2
Interim analysis did not reveal any safety concerns by the DSMB, but unblinded data did not provide support to continue. Event rate did not meet projected magnitude; given low recruitment potential, it is unlikely that a positive result will occur.
Study has been terminated. Interim analysis did not reveal any safety concerns by the DSMB with hydroxychloroquine treatment, but unblinded data did not provide support to continue due to low numbers of events. Event rate did not meet projected magnitude; given low recruitment potential, it is unlikely that a positive result will occur.
NCT03911336
Details
2022-06-21
Interventional
40 
Acetaminophen Anti-Inflammato… Ketoprofen
Tooth Loss
Decided not to proceed
-
NCT03850535
2018-002964-25
Details
2022-06-21
Interventional
1/224 
Cytarabine Daunorubicin
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
Sponsor's decision to terminate the study after Phase 1; will not proceed with Phase 2.
-
NCT03834571
Details
2022-06-21
Interventional
20 
Albumin-Bound P… Carboplatin Cisplatin Paclitaxel
Carcinoma Carcinoma, Aden… Carcinoma, Squa… HIV Infections Uterine Cervica… Cervical Adenoc… Cervical Adenos… Cervical Squamo… FIGO Stage IIB … FIGO Stage III … FIGO Stage IVA … HIV Infection
Not approved by CTEP
-
NCT02797119
2015-002499-26
Details
2022-06-21
Interventional
4
[4 Refs]
225 
Tranexamic Acid
Hemorrhage Pregnancy Compl…
Study will be stopped due to the impossibility of reaching the objective of inclusions within a reasonable time frame and taking into account the recommendations of the international WOMAN study
-
NCT04504045
2020-000162-42
Details
2022-06-16
Interventional
110 
Caffeine Efavirenz Losartan Metformin Metoprolol Midazolam
Diabetes Mellit… Diabetes Mellit…
Slow recruitment due to COVID-19, the study was stopped when recruited numbers fulfilled the pre-defined lower sample size.
-
NCT02880371
Details
2022-06-16
Interventional
1/282 
Pembrolizumab
Neoplasms Advanced Solid …
Study was halted prematurely due to insufficient efficacy. Not due to safety reasons.
-
NCT02532660
Details
2022-06-16
Interventional
3111 
Citalopram Dexetimide Escitalopram
Depression
Recruitment difficulties due to monocentric study
-
NCT05279859
Details
2022-06-15
Interventional
1/20 
Gilteritinib
Hematologic Neo… Acute Myeloid L…
Sponsor decision.
-
NCT04630210
Details
2022-06-15
Interventional
10 
Atezolizumab Letrozole
Breast Neoplasm… Breast Cancer
Insufficient resources
-
NCT04546828
Details
2022-06-15
Interventional
20 
Gemcitabine
Cholangiocarcin… Intrahepatic Ch…
problem of sponsor
-
NCT04429685
Details
2022-06-15
Interventional
16 
Ketamine
Healthy
The focus of the laboratory went a different direction given extramural funding
-
NCT03902509
Details
2022-06-15
Interventional
2126 
Pirfenidone
Lung Injury Wounds and Inju… Radiation-induc…
The protocol revision is needed.
-
NCT03110510
Details
2022-06-15
Interventional
20 
Calcium Fluorouracil Irinotecan Leucovorin Levoleucovorin
Biliary Tract N… Biliary Tract C…
institution problem
-
NCT01560585
Details
2022-06-15
Interventional
1/23 
Isotretinoin
Alzheimer Disea… Alzheimer's Dis…
Adverse events in 2/3 participants; study was halted but not restarted after this due to insufficnet funds as well
-