Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04069936
Details
2022-08-02
Interventional
219 
Nivolumab Tadalafil
Carcinoma, Non-… Lung Neoplasms Neoplasms Lung Cancer Lung Cancer Met… Lung Cancer, No… NSCLC Non Small Cell … Non Small Cell … Non-small Cell … Non-small Cell …
Resourcing
-
NCT02972294
Details
2022-08-02
Interventional
3419 
Ferric Compound… Iron Iron isomaltosi… Tranexamic Acid
Fractures, Bone Hip Fractures Anemia Hip Fractures P…
1year inclusion hold due to PV new fact (Monofer hold for risk revaluation) DSMB Interim analysis : 1treatment with important transfusion risk reduction/inclusions issues (COVID)/sites change of practice if study continue=>stop inclusions
-
NCT05451095
Details
2022-08-01
Interventional
10 
Ketamine
Healthy
Termination of project
-
NCT05092581
2021-004535-84
Details
2022-07-29
Interventional
12 
Casirivimab and…
COVID-19
Emerging SARS-CoV-2 variants impacting susceptibility to study drug
-
NCT02743598
Details
2022-07-29
Interventional
44 
Liraglutide
Diabetes Mellit… Diabetes Mellit… HIV Infections Metabolic Syndr… Overweight Diabetes Mellit… HIV Infection Obesity
Lack of funding and time
-
NCT04953052
Details
2022-07-28
Interventional
20 
Imatinib Mesyla…
Acute Lung Inju… COVID-19 Pulmonary Edema Respiratory Dis… Respiratory Dis… Syndrome ARDS Acute Respirato… COVID-19 Acute … Covid19 Pulmonary Oedem…
Number of moderate to severe ARDS patients hospitalised due to COVID19 diminishingly small. Not expected to recruit required minimum number of patients.
-
NCT04560686
Details
2022-07-28
Interventional
22 
Atezolizumab
Carcinoma, Non-… Lung Neoplasms Resectable Lung… Stage I Lung Ca… Stage IA1 Lung … Stage IA2 Lung … Stage IA3 Lung … Stage IB Lung C… Stage II Lung C… Stage IIA Lung … Stage IIB Lung … Stage IIIA Lung… Stage IIIB Lung…
Per PI Request
Two participants were consented; one screen failure. The trial was terminated earlier than planned due to an administrative decision taken by the PI/co-PI in collaboration with the study sponsor based on emerging data made available with the investigational agent being tested in other diseases in the perioperative setting.
NCT01620788
Details
2022-07-27
Interventional
3-
Hydrochlorothia… Indapamide Losartan
Hypertension
Substancial amendment
-
NCT05205759
2021-002612-31
Details
2022-07-26
Interventional
3319 
Bamlanivimab Casirivimab and… Sotrovimab
COVID-19
Stop for futility after the onset of the omicron wave
-
NCT03199963
Details
2022-07-26
Interventional
3223 
Afimoxifene Tamoxifen
Mammographic Br…
Administrative - change in development strategy
Other (Not Including Serious) Adverse Events entries are based on number of subject in the intention-to-treat (ITT) population (blinded phase, safety population). Includes all adverse events reported.
NCT02575339
Details
2022-07-26
Interventional
1/211 
Sorafenib
Carcinoma Carcinoma, Hepa… HCC Hepatocellular … Liver Cancer
Funder Decision
-
NCT01963728
Details
2022-07-26
Interventional
42 
Insulin Insulin Glargin… Insulin, Globin… Insulin, Isopha… Isophane Insuli… Isophane insuli…
Diabetes Mellit…
Blood sugar status of the enrolled subjects wasn't evaluable
-
NCT04762771
NCT04510038
Details
2022-07-25
Interventional
1/22 
Colchicine
COVID-19 Covid19
Recovery Trial showed no convincing evidence that further recruitment would provide conclusive proof of worthwhile benefit for the evaluation of Colchicine in patients with Covid-19.
The rapid decline in COVID patients and other competing trials did not allowed enrollment of additional subjects. Given the small sample size, the study was terminated.
NCT04067492
Details
2022-07-25
Interventional
247 
Diclofenac
Arthritis, Gout… Gout Gout Attack
In view of the continuing insufficient patient recruitment in the study due to the difficult epidemiological situation and the need for rational allocation of company resources, as well as based on the results of the interim analysis.
-
NCT03843853
Details
2022-07-25
Interventional
20 
Bevacizumab Pemetrexed
Colorectal Neop…
cooperation terminated
-
NCT02413138
Details
2022-07-25
Interventional
2/341 
Hormones
Dwarfism, Pitui… Endocrine Syste… Growth Disorder… Pediatric Growt…
The primary endpoint of non-inferiority to daily therapy in the pediatric Phase 3 study was not achieved
-
NCT02793583
Details
2022-07-21
Interventional
2/3710 
Bendamustine Hy…
Leukemia, Lymph… Lymphoma Lymphoma, Large… Lymphoma, Mantl… Lymphoma, Non-H… Diffuse Large B… Follicular Lymp… Mantle Cell Lym… Marginal Zone L… Small Lymphocyt…
Strategic/Business Decision
-
NCT02623439
Details
2022-07-21
Interventional
2-
Cyclophosphamid…
Hematologic Neo… Neoplasms Hematologic Mal…
On hold for toxicitiy
-
NCT00746590
Details
2022-07-21
Interventional
21 
Tretazicar
Carcinoma Carcinoma, Hepa… Hepatocellular …
Study terminated prematurely by sponsor for business reason. One patient was enrolled.
-
NCT03912337
Details
2022-07-20
Interventional
429 
Erenumab
Migraine Disord… Migraine
Terminated [Study would not complete enrollment target until 2026 with results available in 2027. The information will not be useful at that time.]
The study was terminated early due to slow enrollment and the impact of COVID-19 on the work productivity study endpoints, beyond normal operational disruptions.