Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03182673
Details
2022-09-01
Interventional
131 
Fluzoparib Poly(ADP-ribose…
Neoplasms Solid Tumor
Sponsor R & D Strategy Adjustment
-
NCT04320290
Details
2022-08-31
Interventional
40 
Antiviral Agent…
Hepatitis Hepatitis A Hepatitis C Renal Insuffici… Kidney Failure
New Related Protocol to be submitted
-
NCT01840046
Details
2022-08-31
Interventional
1/24 
Interleukin-2
Alopecia Alopecia Areata
-
-
NCT04854889
Details
2022-08-30
Interventional
23 
Decitabine
Anemia Anemia, Aplasti… Refractory Apla…
Not achieve the desired effect
-
NCT04470622
Details
2022-08-30
Interventional
227 
Aprepitant
COVID-19
Study was terminated early by Heron, and was not terminated for safety reasons.
Study was terminated early by Heron, and was not terminated for safety reasons. The data reported is only safety data generated from the study.
NCT00936832
2008-005959-19
Details
2022-08-30
Interventional
20 
Calcium Fluorouracil Irinotecan Leucovorin Levoleucovorin Sunitinib
Rectal Neoplasm… Colorectal Canc… Metastatic Canc…
because the sunitinib showed futility in anotehr trial
-
NCT00819221
2008-007680-17
Details
2022-08-30
Interventional
144 
Doxorubicin Liposomal doxor… Olaparib
Neoplasms Solid Tumors
-
-
NCT03483883
Details
2022-08-26
Interventional
16 
Avelumab Gemcitabine
Metastatic sRCC
The study was terminated due to protracted accrual and limited patient engagement in the setting of rapidly changing treatment paradigms for advanced RCC with sarcomatoid features and/or intermediate/poor risk clinical features.
-
NCT04746339
Details
2022-08-25
Interventional
4411 
Apixaban
COVID-19 Thrombosis Covid19
Due to the decrease in COVID cases and in the recruitment rate, and DSMB orientation.
-
NCT04528758
Details
2022-08-24
Interventional
1-
Rhodamine 6G
Coronary Artery…
re-evaluation of radiotracer
-
NCT03445000
2017-002063-17
Details
2022-08-24
Interventional
2
[5 Refs]
14 
Alectinib
Carcinoma, Non-… Lung Neoplasms Non-small Cell … Non-small Cell … Non-small Cell …
Low recruitment rate
-
NCT00669071
Details
2022-08-23
Interventional
456 
Fluocinolone Ac… Hydroquinone Tretinoin
Melanosis Melasma
Enrollment closed
-
NCT04139395
Details
2022-08-22
Interventional
30 
Citric Acid Gallium citrate Sodium Citrate
Fever Fever of Unknow…
Not feasible at this time.
-
NCT03778073
Details
2022-08-22
Interventional
118 
Antibodies, Mon… Bendamustine Hy…
Lymphoma Lymphoma, B-Cel… B-cell Non Hodg… Richter's Trans…
Strategic/Business Decision
-
NCT03422523
2016-002654-21
Details
2022-08-22
Interventional
253 
Atezolizumab Gemcitabine Oxaliplatin Rituximab
Lymphoma Lymphoma, B-Cel… Lymphoma, Large… Diffuse Large B… Refractory Diff… Relapsed Diffus…
Failure to reach pre-specified futility boundary
-
NCT03379051
Details
2022-08-22
Interventional
1/278 
Lenalidomide Venetoclax
Leukemia, Lymph… Chronic Lymphoc… Non-Hodgkin Lym…
Strategic/Business Decision
-
NCT01975272
Details
2022-08-22
Interventional
427 
Ferric Compound… Ferrous fumarat… Iron
Anemia Postoperative A…
Disapointing randomization rate
Evident conclusions cannot be drawn from this small prematurely stopped study.
NCT04360135
Details
2022-08-18
Interventional
2/30 
Acetaminophen
Pain, Postopera… Post Operative …
The study was closed on 3/8/2021 as per final progress report issued by the IRB on 3/12/2021. No subjects were enrolled in the study following approval. Status changed to "Withdrawn (No Participants Enrolled)" accordingly.
-
NCT03970382
Details
2022-08-18
Interventional
121 
Aldesleukin Interleukin-2 Nivolumab
Neoplasms Solid Tumor
Business decision
-
NCT02341625
2014-002485-70
Details
2022-08-18
Interventional
1/2126 
Nivolumab
Advanced Cancer
Study terminated for business reasons not related to safety.
-