Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03308786
Details
2022-09-28
Interventional
29 
Aldesleukin Interleukin-2
HIV Infections HIV Infection
There were 3 instances of adverse events which were discussed with external safety monitoring committee and it was recommended that the study be terminated.
On the basis of recommendation of the SMC, the study was terminated. Because of this, the primary objective could not be achieved and most of the secondary objectives could not be achieved.
NCT01407562
Details
2022-09-28
Interventional
134 
Carboplatin Paclitaxel
Neoplasms Breast Cancer -… Unspecified Adu…
-
-
NCT04282174
Details
2022-09-27
Interventional
20 
Busulfan Cyclophosphamid… Fludarabine Melphalan Thiotepa
Hematologic Dis… Hematologic Neo… Leukemia Leukemia, Lymph… Leukemia, Myelo… Leukemia, Myelo… Neoplasms Precursor Cell … Acute Lymphobla… Acute Myeloid L… Chronic Lymphoc… Chronic Myeloge… Hematologic Mal…
Study was split into two new studies before the first participant was enrolled.
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NCT02388178
Details
2022-09-27
Interventional
20 
Fluorides
Dental Caries
The study was stopped due to business reasons.
-
NCT02562443
2015-001476-22
Details
2022-09-26
Interventional
3
[1 Refs]
372 
ON 01910
Anemia, Refract… Anemia, Refract… Myelodysplastic… Preleukemia Syndrome MDS Myelodysplastic… RAEB Refractory Anem…
Top line analysis indicated that the study had failed to achieve its primary endpoint.
-
NCT02943733
Details
2022-09-23
Interventional
118 
Temozolomide
Neoplasms Neuroendocrine … Cancer Tumors
closed per sponsor request, for slow enrollment
-
NCT02818894
Details
2022-09-23
Interventional
4135 
Bupivacaine Lidocaine
Total Hip Arthr…
This study was terminated due to pressing matters related to the COVID-19 pandemic - staff shortages and changes of personnel, data gaps due to the pandemic, participants not being able to continue follow-up visits, and ongoing enrollment issues.
The study was terminated due to extended suspension of the study related to personnel issues and pandemic-related issues. Missing data due to lost study records limited the number of available data points.
NCT05268497
Details
2022-09-22
Interventional
10 
Antidepressive … Esketamine
Depression Depressive Diso… Depressive Diso…
due to budget decision and wanting to pursue other research priorities
-
NCT04407390
Details
2022-09-22
Interventional
20 
Niacin Niacinamide Nicotinic Acids
COVID-19 COVID
No volunteers where recruited to this study. Other studies were prioritised over this at the time of enrollment.
-
NCT04080076
Details
2022-09-22
Interventional
40 
Tacrolimus
Kidney Diseases Renal Disease
Study was updated and issued a new NCT number.
-
NCT03712787
2018-000268-26
Details
2022-09-22
Interventional
2364 
Tilavonemab
Alzheimer Disea… Alzheimer's Dis…
Discontinued because of lack of efficacy in the parent study (Study M15-566; NCT02880956).
Study M15-570 was discontinued because of lack of efficacy in the parent study (Study M15-566) and 2) the tilavonemab development program was discontinued.
NCT04906382
Details
2022-09-21
Interventional
12 
Albumin-Bound P… Carboplatin Paclitaxel Tislelizumab
Adenocarcinoma,… Carcinosarcoma Colorectal Neop… Endometrial Neo… Mixed Tumor, Mu… Recurrence Lynch Syndrome Metastatic Endo… Mismatch Repair… Recurrent Endom… Recurrent Endom… Recurrent Endom… Recurrent Uteri…
Sponsor reorganization
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NCT04567225
Details
2022-09-21
Interventional
439 
Insulin Glargin…
Acidosis Diabetes Mellit… Diabetic Ketoac… Ketosis Type 1 Diabetes Type 2 Diabetes
Stopped after internal review
The study was closed due to lack of proper resource availability. Since study could not be completed as planned, no analysis was completed.
NCT04265534
Details
2022-09-21
Interventional
240 
Carboplatin Dexamethasone Folic Acid Pembrolizumab Pemetrexed Vitamin B 12
Carcinoma, Non-… Lung Neoplasms KEAP1 Gene Muta… NFE2L2 Gene Mut… NRF2 Gene Mutat… Non-Small Cell … Non-Squamous No… Non-squamous No…
Lack of Clinical Benefit
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NCT03417492
Details
2022-09-21
Interventional
17 
Citric Acid Sildenafil Citr… Sodium Citrate
Brain Concussio… Brain Injuries Brain Injuries,… Post-Concussion… Wounds and Inju… Mild Traumatic … Traumatic Brain…
Difficulty enrolling participants due to COVID emergency, and planned start of new study to address this question in a more rigorous fashion.
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NCT03273153
2016-004387-18
Details
2022-09-21
Interventional
3446 
Atezolizumab Pembrolizumab
Melanoma Advanced BRAFV6…
This study was terminated due to benefit/risk analysis.
-
NCT01902290
2012-003351-11
Details
2022-09-21
Interventional
2421 
Brodalumab
Asthma
Study terminated early due to lack of efficacy observed following interim analysis in Q2 2015. Study Closed once all sites were closed in eClinical
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NCT04830982
Details
2022-09-19
Interventional
10 
Diazoxide
Myocardial Stun…
Withdrawn in IRB.
-
NCT04189952
Details
2022-09-19
Interventional
22 
Acalabrutinib Carboplatin Etoposide Ifosfamide Rituximab
Leukemia Leukemia, Lymph… Leukemia, Lymph… Lymphoma Lymphoma, B-Cel… Lymphoma, B-Cel… Lymphoma, Large… Chronic Lymphoc… Diffuse Large B… Marginal Zone L… Small Lymphocyt…
Investigator Decision
To protect participant privacy and maintain confidentiality, results will not be reported.
NCT04959266
Details
2022-09-16
Interventional
15 
Adavosertib Itraconazole Omeprazole Rifampin
Advanced Solid …
The study terminated because the clinical development programme for Adavosertib has been discontinued
-