Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT05943990
2019-004446-14
Details
2024-03-18
Interventional
15 
Cyclophosphamid… Fludarabine
Liposarcoma Liposarcoma, My… Sarcoma Sarcoma, Synovi… Neoplasms
The study was terminated due to a change in GSK's R&D priorities.
-
NCT05574712
Details
2024-03-18
Interventional
20 
Abiraterone Ace… Belzutifan Leuprolide
Prostatic Neopl… Prostate Cancer
Principal Investigator has decided not to activate this trial.
-
NCT05361915
Details
2024-03-18
Interventional
2-
Abivertinib
Prostatic Neopl… Prostate Cancer Prostate Cancer…
Sorrento Therapeutics filed for chapter 11 bankruptcy.
-
NCT05087914
Details
2024-03-18
Interventional
20 
Carbidopa Carbidopa, levo… Levodopa Naproxen
Acute Pain Pain, Postopera… Bunionectomy Toe Fusion
Study was not started, therefore recruitment did not happen
-
NCT05044429
Details
2024-03-18
Interventional
431 
Lidocaine
Pain, Postopera… Kidney Transpla…
Lack of interest for continuing on by PI and issues with IRB
-
NCT04382898
2018-004321-86
Details
2024-03-18
Interventional
1/275 
Cemiplimab
Prostatic Neopl… Prostate Cancer
Sponsor decision
-
NCT03596073
Details
2024-03-18
Interventional
143 
Calcipotriene Petrolatum
Breast Neoplasm… Breast Cancer
Interim analysis did not show the required cytokine induction by topical calcipotriene to justify continuation of the trial
-
NCT03098355
Details
2024-03-18
Interventional
1/20 
Interleukin-2
Leukemia, B-Cel… Leukemia, Lymph… B-Cell Leukemia B-Cell Lymphoma
The company did not offer the appropriate CART services.
-
NCT02696291
Details
2024-03-18
Interventional
17 
Pharmaceutical …
Infections Virus Diseases Viral Infection
Product development halted for business reasons.
Study was terminated after Cohort 1. While no analysis was performed for change from baseline for physical exam (PE, a secondary endpoint), any change from baseline PE was reported/analyzed as an AE. AUC0-inf (secondary endpoint) was not calculated.
NCT01311674
Details
2024-03-18
Interventional
3141 
Vaccines
Hepatitis Hepatitis B Healthy Volunte…
Prematurely terminated due to failure to meet study objectives.
This reporting only covers the interim analysis data collected within a 12 month period between enrolment of the first subject on 9 September 2009 and the interim analysis report cut off date of 1 September 2010.
NCT06312800
Details
2024-03-15
Interventional
20 
Acamprosate Methazolamide
Essential Tremo… Tremor
Study was never initiated.
-
NCT06077669
Details
2024-03-15
Interventional
40 
Methylphenidate
ADHD
Study withdrawn in IRB by PI
-
NCT05472506
Details
2024-03-15
Interventional
10 
Nivolumab
Carcinoma Head and Neck N… Squamous Cell C… Head Cancer Head Cancer Nec… Head and Neck C… Head and Neck S… Neck Cancer Neck Carcinoma
Sponsor Decision
-
NCT05193370
Details
2024-03-15
Interventional
40 
Angiotensin II Angiotensinogen Arginine Vasopr… Giapreza Vasopressins
Shock Shock, Septic Septic Shock
Funding and protocol changes. Replaced with new pilot trial.
-
NCT04729348
Details
2024-03-15
Interventional
210 
Lenvatinib Pembrolizumab
Meningeal Carci… Neoplasm Metast… Neoplasms Leptomeningeal … Solid Tumor Solid Tumor, Ad…
Planned interim analysis
-
NCT04498468
Details
2024-03-15
Interventional
477 
Dexamethasone
Dry Eye Syndrom… Keratoconjuncti… Dry Eye
The study was terminated prematurely due to administrative reasons; loss of several research personnel. Because of strict eligibility criteria, the investigators anticipated delays in completing enrollment and therefore decided to terminate early.
The study was not able to enroll its planned sample size. VAS, while consistently used in measuring clinical symptoms of illnesses, is limited in that patients may encounter difficulties in rating their symptomology, especially if the participants feel ambivalent towards the VAS prompts.
NCT04410042
Details
2024-03-15
Interventional
315 
Tranexamic Acid
Bone Neoplasms Cancer of the B… Limb Salvage
Per sponsor
-
NCT03519308
Details
2024-03-15
Interventional
13 
Gemcitabine Nivolumab Paclitaxel
Pancreatic Neop… Pancreatic Canc…
The accrual goal could not be met and the drug manufacturer pulled support
-
NCT03463460
Details
2024-03-15
Interventional
2-
Pembrolizumab Sunitinib
Carcinoma Thymoma Thymic Carcinom…
PI decision
-
NCT02621021
Details
2024-03-15
Interventional
220 
Aldesleukin Cyclophosphamid… Fludarabine Pembrolizumab
Melanoma
The team is revising the protocol design and has chosen to put the study on hold until those changes are approved.
-