Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04450654
Details
2022-10-24
Interventional
20 
Immunoglobulins…
Muscular Diseas… Immune-Mediated…
No Participants Enrolled
-
NCT05028946
2021-002698-24
Details
2022-10-20
Interventional
10 
Muromonab-CD3
Crohn Disease Crohn's Disease
For business reasons
-
NCT04454567
Details
2022-10-20
Interventional
22 
Reverse Transcr…
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch… Hepatitis, Chro… Chronic Hepatit…
Study stopped due to a change in the Sponsor's overall development strategy from treatment of chronic disease to finite, curative treatments, and is based partially on the advice and feedback from experts and regulators.
Study ABI-H0731-205 was terminated early by the study Sponsor for strategic reasons to prioritize research and development efforts on finite and curative HBV therapies. At the time of early termination, only 2 participants were enrolled, both of which discontinued their assigned study treatment early due to the study being terminated early by the Sponsor. As a result, the primary outcome of number of participants with HBV DNA
NCT03693846
Details
2022-10-20
Interventional
211 
Ipilimumab Nivolumab
Adenocarcinoma Adenocarcinoma,… Appendiceal Neo… Cystadenocarcin… Mucinous Adenoc… Mucinous Adenoc…
Terminated due to slow enrollment and lack of efficacy
Early termination leading to small numbers of subjects analyzed.
NCT02303405
Details
2022-10-20
Interventional
222 
Hydroxychloroqu… Pioglitazone
Diabetes Mellit… Diabetes Mellit… Hyperglycemia Diabetes Mellit…
Investigator decision
Small sample size, Unblinded
NCT02055963
Details
2022-10-20
Interventional
230 
Minocycline
Head and Neck N… Head And Neck C…
Early termination due to the protocol lack of progress in improving accrual rate
Early termination due to the protocol lack of progress in improving accrual rate.
NCT03249844
2017-002247-15
Details
2022-10-19
Interventional
30 
Methylprednisol… Methylprednisol… Methylprednisol… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph…
Ischemic Stroke Stroke Arterial Ischem…
discontinuation of the trial
-
NCT02432378
Details
2022-10-19
Interventional
1/2-
Celecoxib Cisplatin Vaccines
Carcinoma, Ovar… Neoplasms Ovarian Neoplas… Cancer of Ovary Cancer of the O… Neoplasms, Ovar… Ovarian Cancer Ovary Cancer Ovary Neoplasms
-
-
NCT01855607
Details
2022-10-19
Interventional
211 
Menthol
Peripheral Nerv… Breast Cancer Colon Cancer Neuropathy
Lack of feasibility
-
NCT05231603
Details
2022-10-18
Interventional
350 
Ivermectin
COVID-19
Poor response
-
NCT04088591
Details
2022-10-18
Interventional
30 
Ascorbic Acid
Sepsis Toxemia
Recent studies suggest an increase in mortality due to high-does Vitamin C
-
NCT05239910
Details
2022-10-17
Interventional
20 
Tenalisib
Lymphoma Lymphoma, T-Cel… Lymphoma, T-Cel… Peripheral T Ce…
Change in development plan
-
NCT05130086
Details
2022-10-17
Interventional
20 
Islatravir
Acquired Immuno… HIV Infections Infections Human Immunodef…
Business Reasons
-
NCT04811404
Details
2022-10-14
Interventional
40 
Eicosapentaenoi…
Bipolar Disorde…
Reassessment of rationale for study
-
NCT03612466
Details
2022-10-14
Interventional
10 
Calcium Calcium Carbona… Plerixafor
Osteosarcoma Bone Metastases
Study withdrawn before any participants could be enrolled. Issues being able to effectively recruit participants into the study.
-
NCT03359161
Details
2022-10-13
Interventional
2/39 
Furosemide
Heart Failure
Development of first generation device discontinued.
-
NCT01464593
Details
2022-10-13
Interventional
22 
Doxorubicin Liposomal doxor…
Colonic Neoplas… Neoplasm Metast… Colon Cancer Li…
trial design contingent on RFA optimization
-
NCT02716805
Details
2022-10-12
Interventional
16 
Durvalumab Melphalan Tremelimumab
Multiple Myelom…
FDA placed on partial hold due to additional data
Early termination due to safety signals in other studies investigating combination regimens comprising similar drugs. Because only 6 subjects were enrolled, no final statistical analysis plan was issued and no formal data analyses were performed.
NCT04022876
Details
2022-10-10
Interventional
135 
Carboplatin Pemetrexed Topotecan
Lung Neoplasms Small Cell Lung… Non Small Cell … Small-cell Lung…
With a favorable safety profile the difference between treatment groups for the primary composite endpoint was not sufficient to generate statistically significant results with the targeted sample size
-
NCT03933865
Details
2022-10-10
Interventional
11 
Hydromorphone Ketamine
Acute Pain Opioid-Related … Opioid-use Diso… Pain, Acute
The COVID-19 pandemic and recruitment difficulties prompted the investigators to terminate study early.
-