Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT05550519
2021-005588-39
Details
2022-10-31
Interventional
10 
Entecavir Tenofovir
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch…
Sponsor decision after reevaluation of strategy in the context of recruitment timelines projection
-
NCT04684394
Details
2022-10-31
Interventional
250 
Aflibercept
Macular Degener… Retinal Degener… Retinal Disease… Wet Macular Deg… Neovascular Age… Retinal Disease
Sponsor decision
-
NCT04429880
Details
2022-10-31
Interventional
20 
Oxytocin
Osteoarthritis,…
Study was not initiated; no subjects enrolled. A replacement study will be submitted
-
NCT03579472
Details
2022-10-31
Interventional
138 
Halichondrin B
Breast Neoplasm… Triple Negative… Anatomic Stage … Metastatic Trip… Prognostic Stag…
Due to the fact that the sponsor decided not to move forward with the development of M7824
-
NCT03472872
Details
2022-10-31
Interventional
4500 
Acetaminophen Ketorolac
Emergencies Headache
no longer recruiting or studying
-
NCT02598778
Details
2022-10-31
Interventional
212 
Chlorhexidine Chlorhexidine g… Fluorides Listerine Sodium Fluoride
Dental Caries
Study discontinued early due to time constraints and lack of selectivity in agar used in the identification of the target (Streptococcus mutans). Only 12 participants out of a planned 40 were enrolled.
-
NCT04441398
Details
2022-10-28
Interventional
2/30 
Nitazoxanide
COVID-19 covid19
Sponsor's strategic decision
-
NCT04435314
Details
2022-10-28
Interventional
20 
Nitazoxanide
COVID-19 covid19
Sponsor's strategic decision
-
NCT03521934
2017-003510-16
Details
2022-10-28
Interventional
31222 
(2S,3R,4R,5S,6R…
Diabetes Mellit… Diabetes Mellit… Heart Failure Type 2 Diabetes…
Study terminated due to business decision
Limitations of the trial such as small numbers of participants analyzed or technical problems leading to unreliable data. The study was terminated prematurely due to business decision.
NCT03315143
2017-002644-32
Details
2022-10-28
Interventional
310584 
(2S,3R,4R,5S,6R…
Diabetes Mellit… Diabetes Mellit… Kidney Diseases Renal Insuffici… Chronic Kidney … Heart Failure Type 2 Diabetes…
study terminated due to business decision
The study was terminated prematurely due to business decision.
NCT02811783
Details
2022-10-28
Interventional
359 
Naloxone
Lymphoma Lymphoma, T-Cel… Lymphoma, T-Cel… Mycoses Mycosis Fungoid… Pruritus Sezary Syndrome Sézary Syndrom…
Sponsor decision
-
NCT05433402
Details
2022-10-27
Interventional
1/20 
Chlorpromazine
Colonic Neoplas… Colon Cancer St…
Organizational safety isues
-
NCT05209165
Details
2022-10-27
Interventional
4-
Semaglutide
Atrial Fibrilla… Overweight Obesity
Company decision
-
NCT03578198
Details
2022-10-27
Interventional
212 
Rituximab
Lymphoma Lymphoma, Non-H… CD20-positive N…
Issues in supply of IP
-
NCT03119038
Details
2022-10-27
Interventional
40 
Bupivacaine Clonidine Epinephrine Ketorolac Ropivacaine
Joint Diseases Osteoarthritis Pain, Postopera… Degenerative Jo…
Investigator no longer actively pursuing this study.
-
NCT03099265
Details
2022-10-27
Interventional
29 
Fluorouracil Irinotecan Leucovorin Oxaliplatin
Adenocarcinoma Pancreatic Canc…
Paused due to COVID. A determination was made to stop the study because it would be impossible to reach the 65% resection rate as outlined in the protocol.
-
NCT02812862
Details
2022-10-27
Interventional
40 
Olodaterol Tiotropium Brom…
Heart Failure COPD
Rationale obsolete
-
NCT05066698
Details
2022-10-25
Interventional
28 
Ophthalmic Solu…
Persistent Corn…
Sponsor undergoing financial hardships - no longer able to support trial; no safety concerns.
-
NCT04780061
Details
2022-10-25
Interventional
390 
Cholecalciferol Vitamin D Vitamin K Vitamin K 2 Vitamins
COVID-19 Covid19
Public PCR testing stopped in Ontario
-
NCT04460430
2019-000710-11
Details
2022-10-25
Interventional
212 
Neratinib
Breast Neoplasm… Breast Cancer
premature termination due to lack of funding
-