Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT05035680
Details
2022-11-17
Interventional
10 
Vaccines
Influenza, Huma… Influenza
Study cancelled
-
NCT04311515
Details
2022-11-17
Interventional
24 
Fluorodeoxygluc…
Alzheimer Disea… Dementia
Samus Therapeutics company closure
-
NCT03935555
Details
2022-11-17
Interventional
111 
9H-purine-9-pro…
Polycythemia Polycythemia Ve… Primary Myelofi… Thrombocythemia… Thrombocytosis Post-Essential … Post-Polycythem… Primary Myelofi…
Samus Therapeutics company closure
-
NCT02783547
Details
2022-11-17
Interventional
10 
Azacitidine
Myelodysplastic… Preleukemia Syndrome Myelodysplastic…
The trial was withdrawn due to problems with the manufacture of the investigational drug.
-
NCT03632642
Details
2022-11-16
Interventional
40 
Floxacillin Penicillin G Penicillin G Be… Penicillin G Pr…
Staphylococcal … Staphylococcus …
Study never commenced
-
NCT03515629
2017-001041-27
Details
2022-11-16
Interventional
35 
Cemiplimab Pembrolizumab
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
Business decision
-
NCT02947581
Details
2022-11-16
Interventional
3107 
Albendazole Praziquantel
Cysticercosis Neurocysticerco… Taeniasis
Albendazole and albendazole placebo are not available in our local suppliers or in the international market. Consequently, it is no possible to re-initiate the enrollment to complete the original sample size.
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NCT05438758
Details
2022-11-15
Interventional
20 
Esketamine Ketamine
Depression Depressive Diso… Depressive Diso… Treatment Resis…
Withdrawn by Sponsor
-
NCT05093387
Details
2022-11-15
Interventional
10 
Carboplatin Pembrolizumab
Breast Neoplasm… Carcinoma Inflammatory Br… Anatomic Stage … Breast Inflamma… Metastatic Trip… Prognostic Stag…
funding issues and pharmacy preparation for the drug
-
NCT03373877
Details
2022-11-15
Interventional
14 
9H-purine-9-pro…
Polycythemia Polycythemia Ve… Primary Myelofi… Thrombocythemia… Thrombocytosis Myelofibrosis Post-essential … Post-polycythem…
Samus is focusing all of their efforts in myelofibrosis on the new oral formulation of PU-H71.
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NCT01905592
Details
2022-11-15
Interventional
3216 
Niraparib
Breast Neoplasm… Carcinoma Neoplasms Ovarian Neoplas… BRCA1 Gene Muta… BRCA2 Gene Muta… Carcinoma of Br… Human Epidermal… Neoplasms, Brea…
The study was terminated due to futility.
IDMC interim analysis concluded that concerns with the quantity and quality of data in the control arm precluded meaningful comparative analyses and generation of a clinically useful endpoint, therefore enrollment was ended prematurely.
NCT00945269
Details
2022-11-15
Interventional
1/23 
Aldesleukin Denileukin dift… Immunotoxins Interleukin-2
Melanoma Recurrent Melan… Stage III Melan… Stage IV Melano…
ONTAK has been pulled off the market for further testing. Subsequently, EISAI will no longer be supporting clinical trials that utilize this drug.
-
NCT05309902
Details
2022-11-14
Interventional
10 
Moxifloxacin
Healthy Volunte…
Study not needed
-
NCT02263508
2014-000185-22
Details
2022-11-14
Interventional
3713 
Pembrolizumab Talimogene lahe…
Melanoma
-
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NCT01881789
Details
2022-11-14
Interventional
1/222 
Cyclophosphamid… Dexamethasone Lenalidomide
Multiple Myelom… Neoplasms, Plas…
A program evaluation identified that the safety profile and pharmacokinetic (PK) characteristics of the formulation used in all oprozomib studies required further optimization and thus enrollment in OPZ003 was halted during dose-escalation.
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NCT04687800
Details
2022-11-10
Interventional
41 
Dexamethasone Difluprednate
Cataract
Inability to enroll due to lack of access to the Ambulatory Surgery Center.
-
NCT03784599
Details
2022-11-10
Interventional
228 
Ado-Trastuzumab… Maytansine Osimertinib Trastuzumab
Carcinoma, Non-…
insufficient effectiveness
-
NCT05611086
Details
2022-11-09
Interventional
416 
Acetylcysteine N-monoacetylcys…
Leukemia Precursor Cell … Lymphoblastic L…
The study stopped because the study period already ended
-
NCT04940871
Details
2022-11-09
Interventional
21 
Favipiravir
Severe Acute Re… Severe Acute Re…
Only one patient was enrolled, who who later withdrew the consent. They decided not to contunie the study.
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NCT04375202
2020-001475-33
Details
2022-11-07
Interventional
2227 
Colchicine
COVID-19
Insufficient rate of patient accrual and newly available scientific evidence
-