Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04334915
Details
2022-12-21
Interventional
20 
Cenicriviroc
Arteritis Inflammation HIV Infections
Industry supporter no longer supporting the study. Protocol A5415's study will run instead.
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NCT04306692
2018-004604-20
Details
2022-12-21
Interventional
412 
Clomiphene Enclomiphene Inositol Zuclomiphene
Polycystic Ovar… Clomiphene Inositol Ovulation Induc…
clomiphene citrate is no longer being considered as standard treatment for polycystic ovary syndrome
-
NCT03739840
2018-002303-33
Details
2022-12-21
Interventional
3
[1 Refs]
232 
Padsevonil
Drug Resistant … Epilepsy Seizures Drug-Resistant … Focal-Onset Sei…
Based on available data, UCB has decided to stop development of padsevonil as adjunctive treatment of focal-onset seizure
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NCT03236805
Details
2022-12-21
Interventional
3285 
Ketamine Morphine
Pain Management
285 patients have recruited instead on 496 but we don't want to continue to prolonge the study. Analysis will be performed on the data we have.
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NCT02607813
2015-003421-33
Details
2022-12-21
Interventional
1142 
Naporafenib Spartalizumab
Melanoma NSCLC Other Solid Tum… Ovarian Cancer
-
-
NCT04851834
Details
2022-12-20
Interventional
1/212 
Carboplatin Cisplatin Temozolomide
Glioma Advanced Solid … High-grade Glio… Platinum-Resist… Platinum-Resist…
Study was terminated by IP Holder (collaborator), PinotBio Inc.
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NCT04042116
Details
2022-12-20
Interventional
1/2-
Nivolumab
Neoplasms Advanced Solid … Gynecologic Can…
Company decision
-
NCT03638128
2018-000550-21
Details
2022-12-20
Interventional
375 
Denosumab
Osteogenesis Im… Osteogenesis Im…
The study was stopped earlier than planned due to safety concerns about high levels of calcium in the blood of the participants
-
NCT03982537
Details
2022-12-19
Interventional
20 
Acetylcysteine N-monoacetylcys…
Head and Neck N… Head and Neck C…
Concept is withdrawn and a different concept will be submitted the near future.
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NCT03481556
Details
2022-12-19
Interventional
1/256 
Bortezomib Daratumumab Dexamethasone Dexamethasone a… Melphalan
Multiple Myelom… Neoplasms, Plas…
The sponsor decided to terminate the study following an FDA request of a partial clinical hold.
On 04 November 2021, the study was terminated early during Phase 2a.
NCT03272217
NCT03133390
Details
2022-12-19
Interventional
216 
Atezolizumab Bevacizumab
Carcinoma, Tran… Urothelial Carc…
Funder decision
-
NCT02987998
Details
2022-12-19
Interventional
19 
Etoposide Pembrolizumab
Carcinoma, Non-… Lung Neoplasms Stage IIIA Non-…
higher than expected rate of toxicity & unrealistic timeline to complete trial under company's proposed plan to reopen
-
NCT02052193
Details
2022-12-19
Interventional
28 
Dabrafenib Vemurafenib
Melanoma Metastatic Mela…
Second cohort not opened because Simon-Two_Step model failed
-
NCT04021017
Details
2022-12-16
Interventional
10 
Estradiol Estradiol 17 be… Estradiol 3-ben… Polyestradiol p…
Anorexia Anorexia Nervos…
PI Workload
-
NCT03971110
Details
2022-12-16
Interventional
4
[1 Refs]
9 
Bicalutamide Goserelin
Prostatic Neopl… Advanced Prosta…
Due to the limited potential patients pool, the enrollment goal could not be achieved. After review and communication, the decision to teminate study was made.
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NCT05496894
Details
2022-12-15
Interventional
20 
Mitoxantrone
Multiple Sclero… Sclerosis Relapsing Multi…
Due to the company's project adjustment, decided to stop this study
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NCT05494619
2021-002968-49
Details
2022-12-15
Interventional
30 
Antibodies Immunoglobulins Immunoglobulins… Rho(D) Immune G… gamma-Globulins
Guillain-Barre … Syndrome Guillain-Barré…
This study has been withdrawn due to an internal decision. The decision was not due to any safety concerns with study drug.
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NCT04420624
Details
2022-12-15
Interventional
2/354 
Colchicine
Infarction Myocardial Infa… Myocardial Infa…
Inclusion period completed
-
NCT03998293
Details
2022-12-15
Interventional
40 
Somatostatin
Healthy
Newly available data suggests that measuring proinsulin clearance would not enhance predictive value of serum proinsulin
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NCT01584934
2011-006336-23
Details
2022-12-15
Interventional
40 
Sodium Oxybate
Fatigue Fatigue Syndrom… Syndrome Chronic Fatigue…
incompatibilities over intellectual property
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