Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01005914
Details
2023-01-06
Interventional
211 
Asparaginase Cyclophosphamid… Cytarabine Dexamethasone Doxorubicin Imatinib Mesyla… Liposomal doxor… Methotrexate Methylprednisol… Methylprednisol… Methylprednisol… Pegaspargase Vincristine
Leukemia Leukemia, Lymph… Precursor Cell …
Increased rate of bacterial infections
Study terminated early due to safety concerns. Only one subject completed the study.
NCT05014919
2010-020493-42
Details
2023-01-05
Interventional
335 
Vortioxetine
Depression Depressive Diso…
The study was terminated based on new efficacy data from another study.
The study was terminated based on new efficacy data from another study. The main primary and secondary efficacy objectives were not assessed due to termination of the study and the limited number of participants who completed the double-blind period.
NCT04786964
Details
2023-01-05
Interventional
325 
Carboplatin Dexamethasone Folic Acid Pemetrexed Vitamin B 12
Carcinoma, Non-… Lung Neoplasms Metastatic Non-…
Regional political conflict
-
NCT03355170
Details
2023-01-05
Interventional
40 
Dexlansoprazole Domperidone Lansoprazole
Cardiovascular … Cardiac Event GERD Safety Issues
The sponsor decided to continue with a different design and a different protocol.
-
NCT01339910
Details
2023-01-04
Interventional
3
[1 Refs]
272 
Busulfan Cyclophosphamid… Fludarabine Fludarabine pho… Melphalan Vidarabine
Leukemia Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Preleukemia Leukemia, Myelo…
Accrual terminated as recommended by the data and safety monitoring board.
-
NCT03484520
2017-003213-26
Details
2022-12-30
Interventional
148 
Venetoclax
Leukemia Leukemia, Myelo… Leukemia, Myelo… Cancer - Acute …
Strategic considerations
-
NCT00849667
2008-005872-29
Details
2022-12-30
Interventional
31100 
Carboplatin Farletuzumab Taxane
Carcinoma, Ovar… Hypersensitivit… Ovarian Neoplas… Ovarian Cancer
Lack of efficacy
Study termination was based on the primary analysis results for progression-free survival (PFS). Data collection and analyses of health care resource utilization were not performed due to the study being terminated early. Pharmacokinetic data was collected and analyzed for a maximum of only 7 participants in this study.
NCT02923531
Details
2022-12-29
Interventional
1/29 
Nivolumab
Carcinoma Carcinoma, Rena… Clear Cell Rena…
Due to low enrollment, the study was terminated early.
Due to low enrollment, the study was terminated early. Data for some pre-registered endpoints were therefore not collected or analysed and could not be reported.
NCT05205447
Details
2022-12-28
Interventional
127 
Carbamazepine Itraconazole
Healthy
Data from part 2 no longer deemed necessary for this program.
-
NCT03662711
Details
2022-12-28
Interventional
4843 
Bronchodilator … Olodaterol
Lung Diseases Lung Diseases, … Pulmonary Disea…
Contract terminated between AIFA and the Sponsor (University of Ferrara)
-
NCT02871297
2008-005356-25
Details
2022-12-28
Interventional
3662 
Vortioxetine
Depression Depressive Diso… Depressive Diso…
The study was terminated based on new efficacy data from another study.
The study was terminated early based on new efficacy data from another study.
NCT02097121
2014-000464-17
Details
2022-12-28
Interventional
356 
Botulinum Toxin… Botulinum Toxin… abobotulinumtox…
Enuresis Urinary Bladder… Urinary Inconti… Overactive Urinary Bladder
-
-
NCT02038634
Details
2022-12-28
Interventional
416 
Betamethasone
Tenosynovitis DeQuervain's Te…
not enough patient data
Early termination due to lack of subject participation; statistical analysis not done due to small numbers. Outcome Measure # 2 was originally posted but was deleted as it was not included as part of the study design. No data was collected for that proposed outcome.
NCT01022138
Details
2022-12-23
Interventional
243 
Cyclophosphamid…
Breast Neoplasm… Breast Cancer
-
-
NCT04515394
2020-001776-15
Details
2022-12-22
Interventional
23 
Cetuximab Tepotinib
Colorectal Neop…
The study was terminated early due to operational challenges identifying suitable participants for screening in the study.
-
NCT03711318
Details
2022-12-22
Interventional
38 
Buprenorphine Buprenorphine, … Naloxone
Heroin Dependen…
continuing study was no longer feasible
-
NCT03704298
Details
2022-12-22
Interventional
115 
Axicabtagene ci… Cyclophosphamid… Fludarabine
Lymphoma Lymphoma, B-Cel… Relapsed/Refrac…
Development program terminated
-
NCT05484167
Details
2022-12-21
Interventional
40 
Methyltestoster… Testosterone Testosterone 17… Testosterone en… Testosterone un…
Erectile Dysfun… Sexual Dysfunct…
They study lost funding and decided to close the study down.
-
NCT05387577
Details
2022-12-21
Interventional
16 
Estradiol Estradiol 17 be… Estradiol 3-ben… Polyestradiol p…
Blood Coagulati… Hemostatic Diso… Clotting Disord… Transgenderism
per MCW IRB
-
NCT04586920
2020-003957-30
Details
2022-12-21
Interventional
1104 
Itraconazole Midazolam
Healthy
Terminated due to safety findings
-