Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04945824
Details
2023-02-06
Interventional
12 
Dexamethasone
Healthy
inserter device did not perform as expected
-
NCT04220125
Details
2023-02-06
Interventional
40 
Ketamine Midazolam
Depressive Diso…
No enrollment
-
NCT03614728
Details
2023-02-06
Interventional
1/230 
Azacitidine GSK-3326595
Leukemia Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Preleukemia Neoplasms
Trial terminated due to internal review of clinical data in context of indication under investigation
-
NCT05135845
Details
2023-02-03
Interventional
2-
Spartalizumab
Adenocarcinoma Gastric Adenoca… Oesophageal Ade…
Sponsor decision up DSMB advice due to unfavorable toxicity profile
-
NCT04334174
Details
2023-02-03
Interventional
20 
Brentuximab Ved…
Lymphoma Lymphoma, T-Cel… Lymphoma, T-Cel… T Cell Lymphoma
accrual not met
-
NCT03523728
2017-004084-12
Details
2023-02-03
Interventional
2/3
[1 Refs]
478 
Venglustat
Polycystic Kidn… Polycystic Kidn…
Interim analysis for futility of the Stage 1 of the EFC15392 study met the protocol specified stopping rule based on the primary endpoint. EFC15392 study was stopped for futility based on prespecified criteria and recommendation from DMC
Following decision to discontinue EFC15392 based on the futility analysis, the two-steps analysis initially planned were not applicable, therefore only the final analysis of all safety endpoints (laboratory, vital sign, ECG, physical examination, BDI-II, and lens opacity) were performed on extended combined Stage 1 and Stage 2 safety population only.
NCT02513667
Details
2023-02-03
Interventional
214 
Ceritinib
Adenocarcinoma Adenocarcinoma … ALK-positive No…
The study was terminated after UTSW was informed by Novartis that further support for the study would not be provided
-
NCT04650217
Details
2023-02-02
Interventional
41 
Carbidopa Carbidopa, levo… Levodopa
Depressive Diso…
Study terminated by sponsor (NIMH)
-
NCT03430791
Details
2023-02-02
Interventional
25 
Ipilimumab Nivolumab
Glioblastoma Recurrence Recurrent Gliob…
Study Investigator/Sponsor decided to end enrollment earlier.
Did not accrue the target number of participants needed to achieve target power and statistically reliable results.
NCT01309074
Details
2023-02-02
Interventional
40 
Pregabalin Sertraline
Anxiety Disorde… Epilepsy Anxiety
No subjects could be enrolled and therefore we decided to withdraw/stop the study.
-
NCT05179772
Details
2023-02-01
Interventional
20 
Olanzapine
Opioid-Related … Opioid Use Diso…
NIDA has advised us to terminate this protocol due to the difficulties in finding appropriate subjects.
-
NCT03548246
Details
2023-02-01
Interventional
20 
Abiraterone Ace… Fludrocortisone Hydrocortisone
Adrenal Hyperpl… Adrenocortical … Adrenogenital S… Hyperplasia Congenital Adre…
This study plan has halted and was withdrawn from the IRB.
-
NCT03251417
Details
2023-02-01
Interventional
211 
Apatinib Irinotecan
Carcinoma Carcinoma, Squa… Esophageal Squa…
Because PD-1 antibodies had been proved to be a standard second-line treatment in esophageal cancer, the potential benefit of present intervention is under re-evaluation.
-
NCT01433328
Details
2023-02-01
Interventional
44 
Lidocaine
Pulmonary Arter…
Safety considerations
-
NCT03876028
Details
2023-01-31
Interventional
110 
Ibrutinib Tisagenlecleuce…
Lymphoma Lymphoma, B-Cel… Lymphoma, Large… Diffuse Large B…
Business reasons
-
NCT03624985
Details
2023-01-31
Interventional
461 
Lidocaine
Pain, Postopera… Opioid Use
Subjects had a high dropout rate. Of 61 consented, 24 did not participate. Reasons: Surgical cancellations; changing procedure type after consent; and staffing issues. The dropout rate of 39% was considered a barrier to publication.
-
NCT01048138
Details
2023-01-31
Interventional
3123 
Biperiden Biperiden lacta…
Brain Injuries Brain Injuries,… Traumatic Brain…
Recruitment and funding issues, together with the event of the SARS-CoV-2 pandemic prompted an adjustment in the study design to stop enrollment at 123 patients.
-
NCT00823342
2008-000733-21
Details
2023-01-31
Interventional
3-
Clevudine Tenofovir
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch… Hepatitis, Chro… Virus Diseases HBe Negative Ch… Hepatitis B Vir…
safety aspects
-
NCT05601648
Details
2023-01-30
Interventional
20 
Psilocybin
Anhedonia Depressive Diso… Depressive Diso… Major Depressiv…
Due to negative results in similar trials using 11C-UCB-J
-
NCT05504486
Details
2023-01-30
Interventional
40 
Brexpiprazole
Depression Depressive Diso… Depressive Diso… Major Depressiv…
Sponsor strategic decision
-