Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04776850
Details
2023-02-21
Interventional
10 
Antibodies Antibodies, Mon… Antilymphocyte … Antineoplastic … BB 1101 Bortezomib Busulfan Cyclophosphamid… Dexamethasone Dexamethasone a… Fludarabine Fludarabine pho… Immunoglobulins Immunoglobulins… Mycophenolic Ac… Rho(D) Immune G… Rituximab Tacrolimus Thymoglobulin gamma-Globulins
Anemia, Sickle … Hemoglobinopath… Thalassemia beta-Thalassemi… Beta Thalassemi… Sickle Beta 0 T… Sickle Beta Plu… Sickle Beta Tha… Sickle Cell Dis… Sickle Cell-SS …
Competing protocol opened in Adult SCT that will include pediatric patients and is now multi-center. No patients enrolled on study.
-
NCT04746495
Details
2023-02-21
Interventional
40 
Eplerenone
Hypertension
Issues relate to COVID-19 and staffing challenges, as well as very tight finances.
-
NCT04155580
Details
2023-02-21
Interventional
168 
Decitabine Decitabine and …
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
Study halted prematurely and will not resume; participants are no longer being examined or receiving intervention
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NCT03602781
Details
2023-02-21
Interventional
30 
Nitric Oxide
Familial Primar… Hypertension Pulmonary Arter…
Decision not to proceed with Study
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NCT03386721
2017-003182-94
Details
2023-02-21
Interventional
2256 
Antibodies Atezolizumab Gemcitabine Vinorelbine
Uterine Cervica… Advanced/Metast…
The Sponsor discontinued the development of Simlukafusp alfa due to portfolio prioritization, not due to any safety, efficacy, or quality issues.
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NCT03135860
Details
2023-02-21
Interventional
17 
Nitric Oxide
Hypertension Hypertension, P… Lung Diseases Lung Diseases, … Pulmonary Disea… COPD Chronic Obstruc… Pulmonary Hyper…
This was an exploratory open-label study and has met its initial objectives
-
NCT02807454
Details
2023-02-21
Interventional
237 
Daratumumab Dexamethasone Durvalumab Pomalidomide
Multiple Myelom… Neoplasms, Plas…
Health Authority request due to class effect
This study stopped enrolling participants on 05-Sep-2017 and was terminated earlier than planned on 03-Jan-2022. This results disclosure report provides outputs from the Simon Stage 1: D2 and PD3 arms. Simon Stage 2: D2 did not enroll any participants.
NCT02725372
Details
2023-02-21
Interventional
3207 
Nitric Oxide
Hypertension Pulmonary Arter…
Trial stopped for futility
Planned Interim Analysis resulted in early termination due to futility, leading to small numbers of study participants analyzed. Analysis is based on Part 1 Blinded Treatment Period (up to 18 Weeks) only.
NCT01769027
Details
2023-02-21
Interventional
20 
Anti-Bacterial … Azithromycin Immunoglobulins… Penicillins Sertraline
Pandas
No participants enrolled
-
NCT01700569
2012-000774-31
Details
2023-02-21
Interventional
124 
Folic Acid Leucovorin Levoleucovorin Temozolomide
Astrocytoma Glioblastoma Grade IV Astroc…
changing the standard of care
-
NCT05730673
Details
2023-02-17
Interventional
20 
Leronlimab
Colorectal Neop… CCR5 Colorectal Canc… Metastatic Microsatellite …
No participants enrolled
-
NCT04965714
Details
2023-02-16
Interventional
20 
Nivolumab
Carcinoma Carcinoma, Hepa… Resectable Hepa…
0 patient accrual
-
NCT04606563
Details
2023-02-16
Interventional
3341 
Azilsartan medo… Candesartan Candesartan cil… Eprosartan Irbesartan Losartan Olmesartan Telmisartan Valsartan
COVID-19 Communicable Di… Coronavirus Inf… Infections Severe Acute Re… Covid19 SARS-CoV Infect…
DSMC recommendation due to futility
-
NCT04485065
Details
2023-02-16
Interventional
1-
Azacitidine
Myelodysplastic… Preleukemia Syndrome
Suspended for changes in development strategy
-
NCT04326764
Details
2023-02-16
Interventional
352 
Panobinostat
Leukemia, Myelo… Myelodysplastic… Preleukemia Acute Myeloid L… Myelodysplastic…
Change of marketing authorisation holder
-
NCT03678428
Details
2023-02-16
Interventional
392 
Floxuridine Irinotecan Leucovorin Oxaliplatin
Colorectal Neop… Liver Metastase… Metastatic Colo…
Production halt of FUDR in China
-
NCT02977286
Details
2023-02-16
Interventional
412 
Bisacodyl Bismuth subsali… Magnesium citra… Methylnaltrexon… Naloxegol
Constipation Paralysis
Poor enrollment
Limitations: One-third of the planned participants were enrolled, thus the study is substantially underpowered. Our results do not apply to non-medical patients.
NCT03663166
Details
2023-02-15
Interventional
1/219 
Ipilimumab Nivolumab
Carcinoma, Non-…
Increased SAE occurrence per PI
-
NCT04507373
Details
2023-02-14
Interventional
43 
Simvastatin
Muscle Cramp Muscle Weakness Spasm Ache Statin Adverse … Weakness, Muscl…
No grant obtained. Enrolled participants were not assigned to the intervention and was study terminated
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NCT03928275
Details
2023-02-14
Interventional
2/30 
Aldesleukin BCG Vaccine Interleukin-2
Melanoma Cutaneous Metas…
Withdrawn prematurely.
-