Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02438007
Details
2023-03-15
Interventional
3953 
3-hydroxy-17-(1…
Prostatic Neopl… Prostate Cancer
-
-
NCT01709734
Details
2023-03-15
Interventional
2126 
3-hydroxy-17-(1…
Prostatic Neopl… Prostate Cancer
Study was terminated prematurely in all investigational study centers upon recommendation from the study's Data Monitoring Committee (DMC). Study was stopped due to lack of efficacy.
-
NCT05065164
Details
2023-03-14
Interventional
2/30 
Denosumab
Denosumab Aller…
no partcipants enrolled
-
NCT04854512
Details
2023-03-14
Interventional
3-
Metformin
Diabetes Mellit… Diabetes Mellit…
Strategic company decision - not related to a safety concern
-
NCT03030131
Details
2023-03-14
Interventional
250 
Durvalumab
Carcinoma, Non-… Lung Neoplasms
Definitive discontinuation according to safety monitoring of death from the 46th patient onwards.
-
NCT04954196
Details
2023-03-13
Interventional
20 
Amlodipine
Frozen Embryo T…
No participants enrolled
-
NCT04521335
Details
2023-03-13
Interventional
12 
Copper Disulfiram
Multiple Myelom… Neoplasms, Plas…
Closed at PI's Request
-
NCT04002011
Details
2023-03-13
Interventional
20 
Apixaban Dabigatran Edoxaban Rivaroxaban Warfarin
Anticoagulant-i…
Submission process abandoned. No patient enrolled.
-
NCT03439033
Details
2023-03-13
Interventional
2273 
Edetic Acid N,N'-bis(2-hydr…
Prostatic Neopl… Prostate Cancer
Study Drug was FDA approved Summer 2021
One limitation is the small number of cases available for specificity analysis resulting in a negligible sample size of patients who had a true negative reference. Another limitation is multiple patients sought care at other institutions. As a result, information was not complete for several patients. Only a small number of the subjects had 2-year follow-up or underwent confirmatory biopsy, which introduces the possibility of selection bias.
NCT02423265
Details
2023-03-13
Interventional
40 
Ranolazine
Angina, Stable Arteriosclerosi… Coronary Artery… Ischemia Myocardial Isch… Chronic Stable …
slow recruitment; local new issues with CMR after study start
-
NCT04203498
2019-002623-14
Details
2023-03-10
Interventional
3238 
Nabiximols
Multiple Sclero… Muscle Spastici… Sclerosis Multiple Sclero…
This study was terminated based on a business decision by the Sponsor.
-
NCT03878927
Details
2023-03-10
Interventional
111 
Gemtuzumab
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
Dose limiting toxicities.
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NCT03639610
2018-000478-31
Details
2023-03-10
Interventional
235 
Dexamethasone Melphalan
Multiple Myelom… Neoplasms, Plas… Renal Insuffici… Renal Impairmen…
The sponsor decided to terminate the study following an FDA request of a partial clinical hold.
Between-group comparisons were not performed in this study due the small number of patients in each cohort, as well as differences with regards to some baseline characteristics.
NCT00543127
2007-003417-14
Details
2023-03-10
Interventional
3
[1 Refs]
870 
Anastrozole Fulvestrant
Breast Neoplasm… Breast Cancer
Unjustified decision of company that funded the trial.
-
NCT04946435
Details
2023-03-09
Interventional
10 
Anti-Bacterial …
Intracranial Pa…
We are no longer going to undertake the study.
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NCT04784559
2020-005951-19
Details
2023-03-09
Interventional
3205 
Dexamethasone Favipiravir Remdesivir
COVID-19 Communicable Di… Infections COVID-19 Infect…
Sponsor has decided to end the study prematurely based on significant difficulties in the recruitment of patients, despite the implementation of corrective measures that still failed to increase the accrual rate required for a feasible completion.
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NCT04412707
Details
2023-03-09
Interventional
227 
Dexamethasone Melphalan
RRMM
The sponsor decided to terminate the study following an FDA request of a partial clinical hold.
-
NCT04277663
Details
2023-03-09
Interventional
3136 
Interferons
Melanoma Acral Melanoma …
Due to the company's development strategy adjustment ,Innovent Bioligics decided not to continue the study after consultation with investigators
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NCT04156659
Details
2023-03-09
Interventional
20 
Tisagenlecleuce…
Leukemia Leukemia, Lymph… Precursor Cell … B-cell Acute Ly…
This study was cancelled before enrolling any patients for business related reasons.
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NCT03948178
Details
2023-03-09
Interventional
3227 
Simendan
Amyotrophic Lat… Motor Neuron Di… Sclerosis
This was an open label extension for patients completing the REFALS study (3119002; NCT03505021). Study 3119002 showed lack of efficacy of ODM109 so the sponsor decided to terminate this study
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