Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03773302
2018-004004-19
Details
2023-04-03
Interventional
348 
Gemcitabine Infigratinib
Cholangiocarcin… Advanced Cholan… FGFR2 Gene Muta…
The sponsor has decided to close the study due to the discontinuation of infigratinib development in oncology within the sponsor's territory. The discontinuation of the study was not due to safety issues.
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NCT03254927
Details
2023-04-03
Interventional
230 
Cetuximab
Carcinoma Carcinoma, Squa… Squamous Cell C… Advanced Head a…
Sponsor decision based on emerging risk-benefit profile
Study was terminated early due to unfavorable risk/benefit profile.
NCT04513314
Details
2023-03-31
Interventional
40 
Quetiapine Fuma… Valproic Acid
COVID-19 Delirium Pneumonia Pneumonia, Vira… Covid19 Hyperactive Del…
coronavirus omicron variant infection typically not associated with delirium and agitation severely hampered recruitment.
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NCT02728037
Details
2023-03-31
Interventional
338 
Lidocaine Magnesium Sulfa…
Pelvic Pain
Low Enrollment, Adoption of investigational treatment into standard practice at our center.
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NCT00251433
2005-000846-35
Details
2023-03-31
Interventional
1
[1 Refs]
53 
Docetaxel Lapatinib Trastuzumab
Breast Neoplasm… Neoplasms, Brea…
EGF100161 (NCT00251433) was terminated in Phase I (Phase II expansion portion of the study was never initiated) by sponsor decision.
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NCT03406715
Details
2023-03-30
Interventional
214 
Ipilimumab Nivolumab
Lung Neoplasms Small Cell Lung… Lung Cancer Relapsed Small … Small Cell Lung…
Sponsor closed study
-
NCT03019588
Details
2023-03-30
Interventional
394 
Paclitaxel Pembrolizumab
Adenocarcinoma Esophageal Neop… Stomach Neoplas… Gastric Neoplas… Gastroesophagea…
Business Reasons
-
NCT01709136
Details
2023-03-30
Interventional
2/33 
MTOR Inhibitors Sirolimus Tacrolimus Temsirolimus
Hypertension
Sirolimus usage discontinued since black box warning
Complete follow-up failed, due to early study termination as a result of FDA black box warning (6/11/2009) about Sirolimus in liver transplant recipients (risk of thrombosis and death).
NCT00572156
2019-000843-29
Details
2023-03-30
Interventional
2106 
Mecasermin
Dwarfism Insulin-like Gr…
The study was prematurely terminated due to strategic reasons.
The study was prematurely terminated once the last subject had completed three years of treatment (compared to the six years planned in protocol Amendment) for strategic reasons.
NCT03426254
Details
2023-03-29
Interventional
10 
Talazoparib
Breast Neoplasm… Advanced or Rec… Breast Neoplasm
the company is liquidated
-
NCT03108690
Details
2023-03-29
Interventional
40 
Ampicillin Anti-Bacterial … Antibiotics, An… Beta Lactam Ant… Cefuroxime Dicloxacillin Lactams Meropenem Penicillin G Piperacillin Piperacillin, T… Tazobactam beta-Lactams
Bacteremia
Logistics
-
NCT02825576
Details
2023-03-29
Interventional
4
[1 Refs]
30 
Glycopyrrolate Neostigmine
Pulmonary Compl…
Lack of Study Personnel
-
NCT05321524
Details
2023-03-28
Interventional
27 
Chenodeoxycholi…
Biliary Atresia
After extensive efforts to improve recruitment, it is deemed not feasible to enroll the requisite number of subjects to generate data needed to meet the study objectives. EMA Paediatric Committee agreed with the Sponsor to terminate this study.
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NCT05077085
Details
2023-03-28
Interventional
40 
Vancomycin
Clostridium Inf… Enterocolitis Enterocolitis, … Infections Clostridioides …
Withdrawn
-
NCT04836533
Details
2023-03-28
Interventional
10 
Antidepressive …
Depression Depressive Diso… Depression in O…
Conflicts at the study site prevented the study from being carried out
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NCT04374253
2020-000766-42
Details
2023-03-28
Interventional
31379 
Antibodies, Mon…
Alzheimer Disea…
Decision to terminate development of Gantenerumab for treatment of prodromal/mild/early-stage Alzheimer's disease following results of a pre-planned analysis of the safety and efficacy of Gant in Graduate I&II (WN29922/WN39658).
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NCT03433755
Details
2023-03-27
Interventional
3259 
Evolocumab
Dyslipidemias Hypercholestero… Mixed Dyslipide… Primary Hyperch…
Prematurely Discontinued Amgen decision
-
NCT05079360
Details
2023-03-24
Interventional
20 
Estrogen Recept… Estrogens Everolimus Exemestane Selective Estro…
Breast Neoplasm… Metastatic Brea…
Decided to halt and will potentially reopen in the future.
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NCT05012787
Details
2023-03-24
Interventional
31 
1018 oligonucle… Vaccines
COVID-19
The study was early terminated considering the inability to enroll the required study population.
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NCT04809116
Details
2023-03-24
Interventional
40 
Pimavanserin
Sleep Initiatio… Stress Disorder… Stress Disorder… Insomnia Chroni… Posttraumatic S…
Received alternative sources of funding.
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