Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03999216
Details
2023-04-12
Interventional
40 
Diuretics Sodium Chloride… Sodium Potassiu…
Heart Failure
Due to administrative and logistical barriers this trial has been withdrawn.
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NCT03465540
Details
2023-04-12
Interventional
124 
Azacitidine Dexamethasone
Hematologic Neo… Leukemia Leukemia, Myelo… Leukemia, Myelo… Multiple Myelom… Myelodysplastic… Preleukemia AML Acute Myeloid L… MDS Myelodysplastic… NHL Non-Hodgkins Ly…
Strategic decisions
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NCT01805804
Details
2023-04-12
Interventional
4-
Valsartan
Ventricular Rem… First Time Dual…
Recall of some valsartan preparations. 88 patients enrolled and completed the observation. All patients are in continuous observation and are well.
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NCT04303559
Details
2023-04-11
Interventional
31 
Antibodies, Bis…
Hemophilia A Hemophilia A Wi…
The INHIBIT Trials IDSMB, in a letter dated 05-18-22, recommended, given the slow enrollment, that the INHIBIT Trials be discontinued due to futility.
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NCT03729245
Details
2023-04-11
Interventional
3623 
Nivolumab Sunitinib
Carcinoma Carcinoma, Rena… Metastatic Rena… Renal Cell Carc…
Sponsor decision
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NCT05492851
Details
2023-04-10
Interventional
46 
Hylan
Osteoarthritis Osteoarthritis,…
The study has only enrolled 6 subjects in 6 months since study initiation. Potential participants are unwilling to participate in the study due to the randomziation and blinding. Both aspects are needed to ensure a robust comparison between groups.
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NCT05411575
Details
2023-04-10
Interventional
20 
Plerixafor
Acute Lung Inju… COVID-19 Respiratory Dis… Respiratory Dis… Syndrome COVID-19 Acute …
No participants Enrolled
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NCT04186299
Details
2023-04-10
Interventional
40 
Carticaine Clonidine Epinephrine
Pulpitis Symptomatic Irr…
Study activities never commenced.
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NCT05087771
Details
2023-04-07
Interventional
4
[35 Refs]
0 
Naltrexone
Alcohol Drinkin… Alcoholism Alcohol Use Dis…
no longer randomized, drug being offered to all patients
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NCT04817345
Details
2023-04-07
Interventional
20 
Plerixafor
Anemia, Sickle … Sickle Cell Dis…
The safety and efficacy of plerixafor in adult and pediatric SCD patients was an unknown when we started. A lot more data from therapeutic trials is available. We feel that recruiting patients without a therapeutic option isn't ethically justifiable.
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NCT04422795
Details
2023-04-07
Interventional
40 
Ethyl Chloride
Nail Diseases
Due to reallocation of resources, this study could not be initiated
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NCT03867500
Details
2023-04-07
Interventional
1-
Niacin
Diabetes Mellit… Diabetes Mellit… Obesity Type 2 Diabetes…
Study halted prematurely but potentially will resume.
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NCT03301896
Details
2023-04-07
Interventional
145 
Spartalizumab
Neoplasms Solid Tumors
Business reasons
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NCT05215951
Details
2023-04-06
Interventional
25 
Osimertinib
Lung Neoplasms Lung Cancer
Enrollment delay study timeline seriously.
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NCT03642132
2017-004456-30
Details
2023-04-06
Interventional
379 
Avelumab Bevacizumab Talazoparib
Carcinoma, Ovar… Ovarian Neoplas… Ovarian Cancer
Phase 3 B9991010 study was stopped due to futility of efficacy at interim analysis on 21Dec2018, and approvals of PARP inhibitors in front-line maintenance setting, Pfizer decided stopping enrollment in the B9991030 study on 19Mar2019.
As of 19 March 2019, the sponsor decided to stop enrollment/randomization in the study. A total of 104 participants were screened and 79 participants completed screening and randomized in the study before study discontinuation. As only 11% projected enrollment was met at the time of enrollment stop, the original study endpoints are no longer applicable and/or feasible; only the Safety, PK and Immunogenicity Analysis were done and these data are included in this report.
NCT05668936
2022-002479-12
Details
2023-04-05
Interventional
131 
Moxifloxacin Norgestimate, e…
Fatty Liver Non-alcoholic F… Non-alcoholic S…
Discontinuing the development of cotadutide, a daily injectable GLP-1/glucagon co-agonist, is based on strategic pipeline considerations. The premature closure is not due to any newly observed safety signals or a change in the risk/benefit profile.
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NCT02927249
Details
2023-04-05
Interventional
33021 
Aspirin
Breast Neoplasm… Node Positive H…
DSMB review
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NCT02890368
Details
2023-04-05
Interventional
156 
Immune Checkpoi… Immunoglobulin … Interferons Talimogene lahe…
Breast Neoplasm… Carcinoma Carcinoma, Merk… Mycoses Mycosis Fungoid… Sarcoma Breast Carcinom… Human Papilloma… Melanoma Merkel-cell Car… Soft Tissue Sar… Solid Tumors Squamous Cell C…
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NCT04354025
Details
2023-04-04
Interventional
20 
Cytarabine Fludarabine Interleukin-2
Leukemia Leukemia, Myelo… Leukemia, Myelo… Refractory Acut… Relapsed Acute …
Principal investigator decided not to move forward with the study.
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NCT01332279
Details
2023-04-04
Interventional
10 
Erlotinib Hydro… Everolimus
Carcinoma Carcinoma, Squa… Carcinoma, Verr… Head and Neck N… Laryngeal Disea… Laryngeal Neopl… Recurrence Salivary Gland … Squamous Cell C… Tongue Neoplasm… Recurrent Metas… Recurrent Saliv… Recurrent Squam… Recurrent Squam… Recurrent Squam… Recurrent Squam… Recurrent Squam… Recurrent Verru… Recurrent Verru… Salivary Gland … Tongue Cancer
Pharmaceutical co. withdrew support. Study was never activated and did not accrue any patients.
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