Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04216797
Details
2023-04-19
Interventional
40 
Diazepam
Anus Diseases Crigler-Najjar … Pain Syndrome Levator Ani Syn…
Enrollment was initially suspended due to COVID pandemic. As the number of cases subsided, enrollment was reopened but never regained momentum. PI has left the site.
-
NCT03790111
Details
2023-04-19
Interventional
253 
Cisplatin Gemcitabine
Biliary Tract N… Biliary Tract C…
Did not meet pre-specified Progression-Free Survival at Month 6 for Stage 2 Analysis
This study was halted prematurely as it did not meet pre-specified Progression-Free Survival at Month 6 for Stage 2 Analysis. Due to early discontinuation of the study with limited data, the study results (data) at Month 12 and End of Study may be unreliable and uninterpretable.
NCT01907009
NCT02349347
2012-000351-14
Details
2023-04-19
Interventional
2/329 
Lenograstim Melphalan
Prostatic Neopl… Castrate Resist…
Early termination
-
NCT01493453
Details
2023-04-19
Interventional
117 
Cyclophosphamid… Fludarabine
Lymphoma, Non-H… CD19 Positive N…
Investigation into serious breach
-
NCT05107427
Details
2023-04-18
Interventional
20 
Avelumab
Carcinoma Carcinoma, Tran… Urothelial Carc…
Sponsor unable to proceed
-
NCT02790710
Details
2023-04-18
Interventional
40 
Propranolol
Compulsive Pers… Obsessive-Compu… Obsessive-compu…
Study has been withdrawn due to reconsideration of study design.
-
NCT02054520
Details
2023-04-18
Interventional
247 
Ipilimumab Nivolumab Pembrolizumab
Melanoma Metastatic Mela… Stage IV Melano…
Withdrawal of IND
Early termination leading to small numbers of subjects analyzed. The enrollment and treatment phase of this trial was terminated early and the IND has been closed.
NCT00004935
Details
2023-04-18
Interventional
3175 
Trastuzumab
Breast Neoplasm… Breast Cancer
Trial is Life long follow-up: to reduce ressources and costs - trial terminated prematurely.
-
NCT05496192
2022-000294-67
Details
2023-04-14
Interventional
20 
Nivolumab
Carcinoma Carcinoma, Tran… Melanoma Urothelial Carc…
Replaced it with another clinical trial
-
NCT04863248
2021-000186-32
Details
2023-04-14
Interventional
210 
Docetaxel
Carcinoma, Non-… Lung Neoplasms Lung Cancer Metastatic Non-… NSCLC
Treatment paradigm in second- and third-line NSCLC is shifting away from docetaxel, the backbone chemotherapy therapy used in this study.
This study was terminated earlier than initially proposed by the Sponsor for non-safety related reasons; only 7 patients were randomized and treated. Therefore, only limited safety summary tables were generated, and no efficacy analyses were conducted.
NCT03618953
Details
2023-04-14
Interventional
18 
Atezolizumab
HPV-Associated …
Virus potency titer of drug product as determined by an improved potency assay was lower than originally determined by the assay described in the IND.
-
NCT03179449
Details
2023-04-14
Interventional
10 
Ferrosoferric O…
Brain Neoplasms Childhood Brain…
Accrual Factor
-
NCT05191862
Details
2023-04-13
Interventional
119 
Cilostazol
Intermittent Cl…
Randomization Error
-
NCT05100160
Details
2023-04-13
Interventional
30 
Gabapentin
Lung Diseases Pulmonary Disea… Thoracic
0 patient accrual
-
NCT04901988
Details
2023-04-13
Interventional
2/38 
Nivolumab
Melanoma Melanoma (Skin) Melanoma, Stage…
Closed earlier than expected due to the need for a redesign to reflect the recent change in standard of care guidelines. New design will include these treatments.
-
NCT04823845
Details
2023-04-13
Interventional
10 
Adapalene
Foot Diseases Warts Plantar Wart
Study never received IRB approval.
-
NCT04540120
Details
2023-04-13
Interventional
249 
Dapansutrile
COVID-19 Cytokine Releas… Syndrome Covid19
Terminated due to the treatment environment for COVID-19 evolving with the pervasiveness of vaccinations and other therapeutic modalities in mitigating against severe infection that has eliminated a viable patient population for study enrollment.
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NCT02680626
Details
2023-04-13
Interventional
486 
Magnesium Sulfa… Ropivacaine
Pain, Postopera…
Pfannenstiel hysterectomies are now rarely performed so cannot recruit eligible patients
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NCT02322814
2014-002230-32
Details
2023-04-13
Interventional
2169 
Albumin-Bound P… Atezolizumab Paclitaxel
Breast Neoplasm… Triple Negative… Breast Cancer
Sponsor's decision
-
NCT04536532
Details
2023-04-12
Interventional
1/2-
Entecavir
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch…
New investigational drug on the same target already in clinical trials
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