Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT06104683
2022-502376-24
Details
2024-03-27
Interventional
20 
Pirtobrutinib
Multiple Sclero… Sclerosis Relapsing Multi…
Sponsor Decision: The trial has been withdrawn with no plans to continue development.
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NCT05770531
Details
2024-03-27
Interventional
2-
Sacituzumab gov…
Breast Neoplasm… Carcinoma Metastatic HER2… Metastatic Trip…
Pending calendar changes
-
NCT03983668
Details
2024-03-27
Interventional
1/2-
Pembrolizumab
Lymphoma
DSMC Deviation Review
-
NCT05724628
Details
2024-03-26
Interventional
10 
Anti-Bacterial …
Acute Disease Appendicitis Acute Appendici…
Project did not receive final IRB approvals. PI decided to withdrawn research study.
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NCT04779151
2020-002766-14
Details
2024-03-26
Interventional
251 
Dostarlimab Niraparib
Adenocarcinoma Biliary Tract N… Carcinoma, Rena… Hypersensitivit… Urinary Bladder… Biliary Tract C… Clear Cell Rena… Gastric Adenoca… Gastro-oesophag… Head and Neck C… Pancreatic Duct… Platinum-sensit… Urothelial Blad…
Abandon by GSK
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NCT04172532
Details
2024-03-26
Interventional
1/2-
Peposertib
Adenocarcinoma Pancreatic Neop… Locally Advance… Locally Advance… Stage II Pancre… Stage III Pancr… Unresectable Pa…
End of Initial Phase of Multi-phase protocol
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NCT04126031
2018-002800-16
Details
2024-03-26
Interventional
248 
Avibactam Avibactam, ceft… Ceftazidime
Bacterial Infec… Gram-Negative B… Infections Gram-negative B…
Following regulatory consultation, the Sponsor has decided to terminate the study and analyze the current dataset. The decision to terminate was solely based on a business decision, not due to safety concerns.
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NCT03699956
Details
2024-03-26
Interventional
318 
Carboplatin Etoposide
Carcinoma, Smal… Lung Neoplasms Small Cell Lung… Carcinoma, Smal…
RRx-001 will be studied under a new global, phase 3 clinical trial
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NCT03504774
Details
2024-03-26
Interventional
258 
Immunomodulatin…
Food Hypersensi… Hypersensitivit… Allergy to Cash… Allergy to Shri… Allergy;Food
Study discontinued due to slow enrollment during COVID-19 pandemic
Due to the COVID-19 pandemic, this study did not enroll the planned number of participants and did not meet the protocol-specified threshold for statistical significance.
NCT04762160
NCT04590820
Details
2024-03-25
Interventional
25 
Rituximab
Lymphoma Lymphoma, Folli… Follicular Lymp…
Decision to terminate EZH-1401 was solely due to company business decision.
The study was terminated early due to business reasons prior to enrolling the target number of participants needed to achieve target power and was insufficient to produce statistically reliable results and was not due to any safety concerns. No summary statistics are available given the limited data from the small number of evaluable participants and individual participant data are also not presented to protect the privacy of the individuals.
NCT04645966
2020-000948-60
Details
2024-03-25
Interventional
2326 
Acetaminophen
Meningococcal V…
The Sponsor decided to discontinue the study based on Sponsor's careful review of available safety data in concert with the recommendation of an independent Data Monitoring Committee.
Study was terminated based on Sponsor's careful review of available safety data in concert with the recommendation of an independent Data Monitoring Committee.
NCT04584684
Details
2024-03-25
Interventional
2128 
Cetylpyridinium Ethanol Hydrogen Peroxi… Povidone
COVID-19 Communicable Di… Coronavirus Inf… Infections Coronavirus Inf… Covid19 SARS-CoV-2 Infe…
The team decided to terminate the trial in order to start a new trial, unrelated to safety reasons
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NCT03701308
Details
2024-03-25
Interventional
2/3-
Cytarabine Daunorubicin
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
End of Initial Phase of Multi-phase protocol
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NCT03257215
Details
2024-03-25
Interventional
4-
Cholecalciferol Ergocalciferols Vitamin D Vitamins
Dermatitis Dermatitis, Ato… Eczema Atopic Dermatit…
Recruitment very slow & funding difficult - exacerbated by COVID-19 pandemic
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NCT06326138
Details
2024-03-22
Interventional
10 
Edoxaban
Bariatric Surge…
No support form the sponsor
-
NCT05705466
Details
2024-03-22
Interventional
1/20 
Pembrolizumab
Carcinoma, Non-… Lung Neoplasms Non Small Cell …
Sponsor Decision
-
NCT05625347
Details
2024-03-22
Interventional
14 
Aspirin
Respiratory Asp… Obstructive Pul… Restrictive Pul…
The pivotal study failed to meet the primary endpoint. Without a successful readout of the pivotal study, there was no longer a purpose for the supportive BORA-1A-C302 study.
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NCT04887831
Details
2024-03-22
Interventional
292 
Avelumab Carboplatin Gemcitabine
Carcinoma Carcinoma, Tran… Neutropenia Urinary Bladder… Bladder Cancer Chemotherapy-in… Metastatic Blad… Myelosuppressio… Urothelial Carc…
Sponsor no longer pursuing trila for the indication.
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NCT04707625
Details
2024-03-22
Interventional
417 
Aflibercept
Retinal Vein Oc…
IRB stopped study due to safety concerns. No further data collection and what has been collected is not appropriate for analysis.
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NCT04691375
Details
2024-03-22
Interventional
186 
Pembrolizumab
Adenocarcinoma … Breast Neoplasm… Carcinoma, Rena… Triple Negative… Advanced Solid … Breast Cancer Colorectal Canc… Gynecologic Can… Hormone Recepto… Lung Adenocarci… Ovarian Cancer Renal Cell Carc… Triple Negative…
Sponsor business decision.
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