Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03002103
Details
2023-04-26
Interventional
3-
Gemcitabine Paclitaxel
Breast Neoplasm… Triple Negative… Triple-Negative…
study design reconsideration
-
NCT04902950
Details
2023-04-25
Interventional
49 
Tranexamic Acid
Hematoma Abdominoplasty Panniculectomy
Logistics
-
NCT03625687
Details
2023-04-25
Interventional
419 
Antiviral Agent… Sofosbuvir-velp…
Hepatitis Hepatitis C Respiratory Ins… Respiratory Fai…
Lack of funding, transitioned to standard of care
Study was terminated prior to completion and prior to meeting enrollment goal primarily due to lack of resources (staffing and funding) and transition of HCV-positive to HCV-negative lung transplants to standard of care. Full planned analysis was not completed due to enrollment number, however primary endpoint was assessed for all 16 subjects receiving treatment.
NCT03149211
Details
2023-04-25
Interventional
30 
UB-421
HIV-1 Infection
project adjustment
-
NCT04775680
Details
2023-04-24
Interventional
1/225 
Antibodies
Lymphoma Lymphoma, Non-H… Non Hodgkin Lym… Solid Tumor
The safety of ADG106 combined with triprilimab has been fully understood.The overall clinical benefit of enrolled subjects was limited and further development of ADG106 was reconsidered.
-
NCT03889756
Details
2023-04-24
Interventional
2/33 
Ketamine Midazolam
Depression Depressive Diso… Depressive Diso… Major Depressiv…
No more funding available to continue since we could not recruit throughout the pandemic.
The study was only able to enroll 3 participants before the pandemic started and then ran out of funding to finish the trial. Presented are summary data and to avoid revealing any identifying information of participants, data is presented overall where applicable (e.g. baseline characteristics).
NCT03635996
Details
2023-04-24
Interventional
3169 
Etripamil
Tachycardia Tachycardia, Su… Tachycardia, Ve… Paroxysmal Supr…
Study was stopped by the Sponsor
-
NCT03068247
Details
2023-04-24
Interventional
30 
Duloxetine Hydr…
Depressive Diso… Depressive Diso… Major Depressiv…
Institution was unable to manufacture radiotracer that was central to the protocol. Study transferred to another institution.
-
NCT01160926
2009-016524-31
Details
2023-04-24
Interventional
131 
Cediranib
Rectal Neoplasm… Rectal Cancer
2 DLTs had been reported from first 4 patients on lowest possible dose cohort.
-
NCT00811122
Details
2023-04-24
Interventional
12 
Corticosterone
Alzheimer Disea… Aphasia, Primar… Dementia Frontotemporal … Pick Disease of… Alzheimer's Dis…
A Fluorine-18 labeled version of the radiopharmaceutical (Flutemetamol) became available. This version is far superior to the Carbon-11 PiB. There is no need to make this compound available any longer.
-
NCT05431179
Details
2023-04-21
Interventional
30 
Ibrutinib
Immune System D… Immunoprolifera… Lymphatic Disea… Lymphoma Lymphoma, B-Cel… Lymphoma, Mantl… Lymphoma, Non-H… Lymphoprolifera…
Due to a strategic reprioritization based on the rapidly changing clinical and commercial landscape for Bruton's tyrosine kinase inhibitors (BTK inhibitors)
-
NCT04424901
Details
2023-04-21
Interventional
241 
Dipyridamole
COVID-19 COVID-19 Pneumo… Vascular Compli…
reduction of Hospitalized COVID patients at UConnHealth
No data obtained beyond 9 days of enrollment. If discharged from care, phone follow up limited to data provided by subject report, up to day 9.
NCT04410445
Details
2023-04-21
Interventional
3765 
Nivolumab
Melanoma Recurrence Melanoma (Skin) Melanoma Stage … Melanoma Stage …
(Sponsor decision)
-
NCT01658826
Details
2023-04-21
Interventional
291 
Pritelivir Valacyclovir
Herpes Genitali… Genital Herpes
-
-
NCT05128344
2021-003015-26
Details
2023-04-20
Interventional
30 
Vigabatrin
Muscle Cramp Spasm Spasms, Infanti…
Strategic decision
-
NCT04590781
Details
2023-04-20
Interventional
1/24 
Pembrolizumab
Carcinoma Carcinoma, Merk… Lung Neoplasms Small Cell Lung… Merkel Cell Car… Small Cell Lung…
The study has been terminated early by the sponsor due to business decision.
Study was terminated by the sponsor and only 2 participants each were enrolled in Parts A and C. No participants were enrolled for Part B. Data were not collected for the prespecified analyses of efficacy, pharmacokinetics, and immunogenicity outcome measures.
NCT01591291
Details
2023-04-20
Interventional
2/30 
Ondansetron
Alcoholism
Grant was transferred to University of Maryland and results were reported under NCT02354703.
-
NCT05220748
Details
2023-04-19
Interventional
10 
Pembrolizumab
Carcinoma Carcinoma, Squa… Squamous Cell C… Cutaneous Squam… Head and Neck S…
Decision was made due to a strategic re-evaluation of pipelines; no patients were enrolled.
-
NCT04748588
Details
2023-04-19
Interventional
446 
Bamlanivimab Sotrovimab
COVID-19 Communicable Di… Cross Infection Infections Covid19 Nosocomial Infe… SARS-CoV2 Infec…
Equipoise requirement no longer met.
-
NCT04735510
Details
2023-04-19
Interventional
30 
Cyclosporine Cyclosporins
Ocular Surface …
study redesigned
-