Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03279861
Details
2023-05-06
Interventional
40 
Sacubitril and … Valsartan
Heart Failure Congestive Hear… Hypertension
protocol change
-
NCT02761694
Details
2023-05-06
Interventional
1
[1 Refs]
78 
Fulvestrant Paclitaxel
Neoplasms Cancer Solid Tumors
Business Reasons
-
NCT01814813
Details
2023-05-06
Interventional
290 
Bevacizumab
Glioblastoma Gliosarcoma Recurrence Recurrent Adult… Recurrent Gliob…
DSMB futility analysis
-
NCT05249569
Details
2023-05-03
Interventional
21 
Avelumab Axitinib Bavituximab
Carcinoma Carcinoma, Hepa… Hepatocellular …
Sponsor pulled support for one of the study drugs.
-
NCT03776864
Details
2023-05-03
Interventional
26 
Immunoglobulin … Immunoglobulins Pembrolizumab
Hodgkin Disease Lymphoma Hodgkin's Lymph…
Company providing drug terminated their oncology program
-
NCT01734694
Details
2023-05-03
Interventional
4100 
Ceftaroline Daptomycin Linezolid Vancomycin
Arthritis, Infe… Bacteremia Endocarditis Healthcare-Asso… Osteomyelitis Acute Bacterial… Health Care Ass… Osteomyelitis/S…
Independent biostatistician recommended early termination of the trial due to low probability of success.
-
NCT05109650
Details
2023-05-01
Interventional
113 
Antibodies Immunoglobulins Pharmaceutical …
Neoplasms Advanced Solid …
Considering that the high budget will affect the subsequent development, it is decided to terminate the test voluntarily
-
NCT05032118
Details
2023-05-01
Interventional
2/30 
Ketamine Propofol
Hemorrhage Subarachnoid He… Subarachnoid He…
Institution change, no IRB approval
-
NCT02376699
Details
2023-05-01
Interventional
1159 
Gemcitabine Paclitaxel Pembrolizumab
Carcinoma Carcinoma, Non-… Carcinoma, Squa… Head and Neck N… Hodgkin Disease Lung Neoplasms Lymphoma Lymphoma, B-Cel… Lymphoma, Folli… Lymphoma, Large… Lymphoma, Non-H… Neoplasm Metast… Neoplasms Neoplasms, Squa… Squamous Cell C… Melanoma Neoplasms, Head… Non-Small Cell … Non-Small Cell … Non-small Cell … Pancreatic Aden… Squamous Cell C… Squamous Cell C… Squamous Cell C… Squamous Cell N…
Study closed due to portfolio prioritization
-
NCT01333514
Details
2023-05-01
Interventional
4
[3 Refs]
14 
Insulin Aspart Insulin deglude… Insulin, Long-A…
Diabetes
-
Early termination due to the PI becoming sick early in the study.
NCT04879589
Details
2023-04-28
Interventional
10 
Abiraterone Ace…
Prostatic Neopl… Metastatic Cast…
Study abandoned, no participants enrolled
-
NCT04872608
Details
2023-04-28
Interventional
10 
Letrozole Onapristone Palbociclib
Breast Neoplasm… Metastatic Brea… Unresectable Br…
The sponsor closed the study due to discontinuing their onapristone program
-
NCT04348006
Details
2023-04-28
Interventional
40 
Bortezomib Cyclophosphamid… Dexamethasone Lenalidomide
Multiple Myelom… Neoplasms, Plas… Newly Diagnosed…
No patients were enrolled in the study
-
NCT03697564
Details
2023-04-28
Interventional
2-
Gemcitabine Nivolumab
Pancreatic Neop… Pancreatic Canc…
Working on getting accurate information for patients interested in the study.
-
NCT00042406
Details
2023-04-28
Interventional
2/383 
Antibodies, Mon… Zanolimumab
Arthritis Arthritis, Rheu… Rheumatoid Arth…
-
-
NCT03953677
Details
2023-04-27
Interventional
332 
Dexmedetomidine Pharmaceutical …
Shock Shock, Septic Septic Shock Vasopressor Res…
Excess mortality in one arm of the study that led to discontinuation of enrollment
-
NCT03097796
Details
2023-04-27
Interventional
10 
Pam2CSK4 acetat…
Hematologic Dis… Stem Cell Trans…
Development plan revised
-
NCT01838174
Details
2023-04-27
Interventional
437 
Methylprednisol… Methylprednisol… Methylprednisol… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph…
Multiple Sclero… Neuritis Optic Neuritis
Sponsor requested
-
NCT01147016
NCT01658969
Details
2023-04-27
Interventional
28 
Cyclophosphamid… Doxorubicin Liposomal doxor… Paclitaxel
Breast Neoplasm… Breast Cancer
Primary co-investigator leaving the institution & funding transfer.
-
NCT03603964
Details
2023-04-26
Interventional
235 
Guadecitabine
Acute Myeloid L… Myeloid Dysplas…
Early termination not due to patient safety
The study was terminated early not due to participant safety.