Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT05736952
Details
2023-05-11
Interventional
20 
Topotecan
Carcinoma, Ovar… Ovarian Neoplas… Platinum-resist…
Program changed
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NCT05458375
Details
2023-05-11
Interventional
111 
Estradiol
Pelvic Organ Pr… Prolapse Urinary Inconti… Pessary Ulcer o… Vaginal Atrophy
There is a lack of potential study participants at our study site that would meet inclusion criteria, therefore, the study is not feasible and is being terminated.
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NCT05284019
Details
2023-05-11
Interventional
432 
Botulinum Toxin… Erenumab abobotulinumtox…
Migraine Disord… Migraine
The study was terminated due to enrolment challenges.
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NCT05251038
Details
2023-05-11
Interventional
1/20 
Fluorouracil Gemcitabine Irinotecan Leucovorin Paclitaxel Sotorasib
Pancreatic Neop… KRAS P.G12C Metastatic Panc… Pancreatic Canc… Unresectable Pa…
Funder Decision
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NCT05232227
Details
2023-05-11
Interventional
2/30 
Primaquine
Malaria Malaria, Vivax Relapse
Trial terminated by funder
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NCT03705507
2016-003904-29
Details
2023-05-11
Interventional
1/212 
Dexamethasone
Leukemia Leukemia, Lymph… Precursor Cell … Acute Lymphobla… Acute Lymphobla… Acute Lymphobla… Acute Lymphobla… Acute Lymphobla…
Poor recruitment, due to a change in the standard of care for this patient population with the use of CAR-T cells
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NCT05328102
Details
2023-05-09
Interventional
23 
Lenalidomide
Lymphoma Lymphoma, B-Cel… Diffuse Large-c…
The study has been terminated early by the sponsor due to business decision.
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NCT05317676
Details
2023-05-09
Interventional
20 
Palmidrol
Fibula Fracture… Fractures, Bone Knee Fractures Tibial Fracture… Fibula Fracture Knee Fracture
Sponsor suspending temporarily.
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NCT05295927
2022-000946-14
Details
2023-05-09
Interventional
13 
Abiraterone Ace… Prednisolone Prednisone
Prostatic Neopl…
Administrative Decision
-
NCT04326283
Details
2023-05-09
Interventional
1/223 
Riluzole Trametinib
Amyotrophic Lat… Motor Neuron Di… Sclerosis
Terminated as it is considered that necessary data have been collected
-
NCT02914938
Details
2023-05-09
Interventional
197 
Rituximab Zanubrutinib
Leukemia, Lymph… Lymphoma Lymphoma, B-Cel… Lymphoma, B-Cel… Lymphoma, Large… Lymphoma, Mantl… Lymphoma, Non-H… Chronic Lymphoc… Diffuse Large B… Follicular Lymp… High Grade Non-… Mantle Cell Lym… Marginal Zone B… Small Lymphocyt…
discontinuation of zandelisib program
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NCT01728259
Details
2023-05-09
Interventional
118 
Bortezomib Dexamethasone Pomalidomide
Amyloidosis Immunoglobulin … Multiple Myelom… Light Chain Dep… Primary Systemi…
FDA placed the study on a clinical hold, due to the concerns by the FDA and Health Canada, Celgene decided to permanently close the study.
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NCT05466747
2022-502171-30
Details
2023-05-06
Interventional
40 
Alpha 1-Antitry… Protease Inhibi…
Alpha 1-Antitry… Emphysema Lung Diseases Lung Diseases, … Pulmonary Disea… Alpha1-Antitryp… Chronic Obstruc…
Business decision
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NCT05074992
Details
2023-05-06
Interventional
21 
Ipilimumab
Glioblastoma
Support withdrawn from drug company supplying IMP
-
NCT05022329
Details
2023-05-06
Interventional
2/3268 
Vaccines
COVID-19 Kidney Diseases Renal Insuffici… Chronic Kidney …
Trial participants became eligible to receive their 4th dose of the COVID-19 vaccine vaccine thus data collected from the 12 month follow-up after 3rd dose vaccine, as per current protocol, would not not be relevant to the study outcomes.
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NCT04415476
Details
2023-05-06
Interventional
2
[1 Refs]
0 
Mycophenolic Ac… Prednisone Sirolimus Tacrolimus
Chronic Rejecti… Decreased Immun… Disorder Relate…
Study did not proceed to IRB approval.
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NCT04335006
Details
2023-05-06
Interventional
380 
Apatinib Paclitaxel
Breast Neoplasm… Triple Negative… Breast Cancer Triple Negative…
Sponsor R & D Strategy Adjustment
-
NCT04313088
Details
2023-05-06
Interventional
2/30 
Eluxadoline
Diarrhea Diabetes Diabetic Diarrh…
This study did not enroll any subjects
-
NCT04161118
Details
2023-05-06
Interventional
23 
Tisagenlecleuce…
Lymphoma Lymphoma, B-Cel… Lymphoma, Non-H… Non Hodgkin Lym…
Termination of the funding agreement by the financial sponsor of the study. Small number of patients enrolled, none of the planned analyses will be feasible to draw conclusions on the safety or efficacy of the therapy.
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NCT03797066
Details
2023-05-06
Interventional
413 
Elbasvir-grazop…
Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch…
Changing parameters in HCV management, resulted in poor recruitment; additionally onset of SARS CoV2 resulted in the cessation of all mobile clinical services.
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