Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02994784
Details
2023-05-24
Interventional
227 
Melphalan
Amyloidosis Immunoglobulin … Amyloidosis; Sy…
Slow Accrual during COVID pandemic, alternative treatments available. Study halted early.
Study was halted early resulting in relatively small numbers of participants analyzed.
NCT04063865
Details
2023-05-23
Interventional
314 
Everolimus Tacrolimus
Renal Insuffici… Kidney Failure
Study was larger than expected and became a burden to faculty and staff resources.
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NCT02382406
Details
2023-05-23
Interventional
1/246 
Carboplatin Paclitaxel Pembrolizumab
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
The study was completed. It was fully accrued.
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NCT00946712
Details
2023-05-23
Interventional
31333 
Albumin-Bound P… Antibodies Antibodies, Mon… Antineoplastic … Bevacizumab Carboplatin Cetuximab Endothelial Gro… Immunoglobulin … Immunoglobulins Paclitaxel
Adenocarcinoma Adenocarcinoma … Carcinoma Lung Neoplasms Recurrence Recurrent Large… Recurrent Lung … Recurrent Squam… Stage IV Large … Stage IV Lung A… Stage IV Squamo…
terminated at pre-planned futility analysis
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NCT04703426
Details
2023-05-22
Interventional
20 
Pembrolizumab Sargramostim
Melanoma Metastatic Mela… Stage III Melan… Stage IV Melano… Unresectable Me…
Study terminated by sponsor
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NCT04493320
Details
2023-05-22
Interventional
45 
Carbidopa Carbidopa, levo… Levodopa
Depression Depressive Diso… Cognitive Impai… Gait Impairment
Study terminated by sponsor (NIMH)
Data collected in the trial have been presented as required but are considered unreliable.
NCT03892018
Details
2023-05-22
Interventional
129 
Paclitaxel
Solid Tumor, Ad…
STUDY HALTED DUE TO FINANCIAL CONTRAINTS
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NCT03761030
Details
2023-05-22
Interventional
451 
Carbidopa Carbidopa, levo… Levodopa
Depression Depressive Diso… Depressive Diso… Dysthymic Disor… Dysthymia Major Depressiv…
The project end date was reached prior to the full sample enrollment
Data collected in the trial have been presented as required but are considered unreliable.
NCT02989597
Details
2023-05-22
Interventional
410 
Dexamethasone Ketamine Methadone Remifentanil Sufentanil
Pain, Postopera…
Due to personnel loss and logistical issues the study was unable to be completed as planned.
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NCT04311489
2019-002268-28
Details
2023-05-18
Interventional
217 
Ularitide
Ascites Fibrosis Liver Cirrhosis Ascites Hepatic Cirrhosis, Live…
Interim analysis showing safety concerns
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NCT05044936
Details
2023-05-17
Interventional
10 
Cannabidiol
Muscle Damage
The researchers were not able to acquire funding to initiate the study. Also, the study was not approved by the local IRB which requested a FDA new drug application.
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NCT04942340
Details
2023-05-17
Interventional
10 
Atipamezole Caffeine Dexmedetomidine
Emergence From …
Withdrawn secondary to a change in protocol design forthcoming.
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NCT02203773
2014-000687-18
Details
2023-05-16
Interventional
1212 
Azacitidine Decitabine Posaconazole Venetoclax
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myelogeno… Myelogenous Leu… Treatment Naive…
Strategic considerations
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NCT05467761
Details
2023-05-15
Interventional
10 
Psilocybin
Healthy
Sponsor was not financially able or willing to continue to support the study
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NCT03997097
Details
2023-05-15
Interventional
30 
Sildenafil Citr…
Heart Diseases Hypertension Hypertension, P… Univentricular … Pulmonary Hyper… Single-ventricl…
New sponsor
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NCT03435458
Details
2023-05-15
Interventional
3429 
Misoprostol
Obesity, Matern… Maternal Obesit…
interim analyses
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NCT02345330
Details
2023-05-15
Interventional
24 
Interleukin-12
Carcinoma Carcinoma, Squa… Squamous Cell C… Head and Neck S…
Due to company resource constraints
-
NCT01579318
Details
2023-05-15
Interventional
22 
Interleukin-12
Lymphoma Lymphoma, T-Cel… Mycoses Mycosis Fungoid… Cutaneous T Cel… Mycosis Fungoid…
Due to company resource constraints
Study enrollment was prematurely terminated under protocol version 6.0. No patients signed informed consent under version 7.0. Two (2) of the targeted 27 patients were enrolled. Thus, a formal statistical analysis was not performed.
NCT04745351
2020-005416-22
Details
2023-05-12
Interventional
3249 
Remdesivir
COVID-19
The study was terminated due to study enrollment feasibility. This decision is not based on efficacy or safety concerns.
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NCT04591002
Details
2023-05-12
Interventional
20 
Osimertinib
Lung Cancer
Further consultation is required, we plan to submit it again as a new project and proceed.
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