Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT05081388
Details
2023-06-18
Interventional
1/225 
Casirivimab and…
COVID-19 SARS-CoV-2
Sponsor Decision
-
NCT05006417
Details
2023-06-18
Interventional
4-
Botulinum Toxin…
Chronic Exertio… Compartment Syn… Syndrome Compartment Syn…
issues with supplier of strength testing equipment
-
NCT03693183
Details
2023-06-18
Interventional
244 
Ketorolac Ketorolac Trome…
Dry Eye Syndrom… Keratoconjuncti… Dry Eye
Study terminated by Sponsor
-
NCT03355300
Details
2023-06-18
Interventional
211 
Cannabidiol
Epilepsy, Absen… Seizures Childhood Absen…
Insys Therapeutics filed Chapter 11 and terminated all studies.
This study was prematurely terminated by the Sponsor. Participants ongoing at the time of discontinuation of the study are neither considered completed or discontinued.
NCT02450331
2014-005603-25
Details
2023-06-18
Interventional
3809 
Atezolizumab
Carcinoma Carcinoma, Tran…
Sponsor decided to terminate the study early because the study did not meet its primary endpoint and because the study had met its goals of providing safety and additional exploratory efficacy information for atezolizumab monotherapy in MIBC.
-
NCT02335944
2014-000726-37
Details
2023-06-18
Interventional
1/2177 
Nazartinib
Carcinoma, Non-… Lung Neoplasms Non Small Cell …
Company decision
-
NCT00209599
Details
2023-06-18
Interventional
2-
Fospropofol
Colonic Polyps Colon Polyps Colonoscopy
-
-
NCT05431582
Details
2023-06-15
Interventional
10 
Bevacizumab Pembrolizumab
Breast Cancer Lung Cancer Ovarian Cancer Pancreatic Canc… Tumors
No participants enrolled
-
NCT04790786
Details
2023-06-15
Interventional
44571 
Bamlanivimab Casirivimab and… Sotrovimab
COVID-19 Covid19
Emergency Use Authorizations for monoclonal antibodies withdrawn
Results are presented before any prespecified statistical trigger was reached. Lack of patient-level variant data limited ability to assess comparative effectiveness relative to variant strains. The EHR eligibility screen identified most, but not all, EUA risk factors and could not identify if a patient was asymptomatic or severely ill. Finally, vaccination status was unable to be ascertained for this cohort which may impact effectiveness of monoclonal antibody therapy.
NCT04578015
Details
2023-06-15
Interventional
416 
Metronidazole
Vaginal Disease… Vaginosis, Bact… Bacterial Vagin…
After screening many patients for BV, it was determined that the rate of BV is less in our population that the 30% rate mentioned in the literature. It was determined that completing the study will not be feasible due to cost and time constraints.
-
NCT04356690
Details
2023-06-15
Interventional
28 
Etoposide
COVID-19
Slow accrual, change in COVID prevalence, availability of effective vaccine
The study was halted prematurely due to slow accrual, change in COVID prevalence, and the availability of an effective vaccine.
NCT03870763
2018-000516-22
Details
2023-06-15
Interventional
311 
Dimethyl Fumara…
Multiple Sclero… Multiple Sclero… Sclerosis
Decision to stop the trial was based on long-term difficulties in fulfilling our enrolment commitments and changes in paediatric MS landscape which no longer support placebo-controlled trials.Decision to stop study was not based on safety concerns.
The study was terminated because of long-term difficulties in fulfilling the enrolment commitments and changes in paediatric MS landscape which no longer support placebo-controlled trials. Decision to stop study was not based on safety concerns.
NCT03509584
2017-001198-18
Details
2023-06-15
Interventional
16 
Ipilimumab Nivolumab
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
SAFETY
-
NCT03267836
Details
2023-06-15
Interventional
19 
Avelumab
Meningioma Meningioma, Adu…
Study sponsor wanted to terminate enrollment.
-
NCT00209586
Details
2023-06-15
Interventional
355 
Fospropofol
Flexible Bronch…
Patient enrollment was stopped prior to completion of the study in order to re-evaluate the dosing regimen.
-
NCT01866930
2012-003280-22
Details
2023-06-13
Interventional
3453 
Interferons Ribavirin
Hepatitis C Hepatitis C, Ch… Infections Chronic Hepatit…
Sponsor decision not based on any new unexpected safety findings or efficacy observations.
The study was ended prematurely, giving few participants an opportunity to reach follow-up week 24
NCT00695214
Details
2023-06-13
Interventional
2
[4 Refs]
-
Propofol
Apnea Sleep Apnea Syn… Sleep Apnea, Ob…
Transfer to another institution
-
NCT05542095
Details
2023-06-12
Interventional
10 
Simvastatin
COVID-19 Olfactory Disor…
Study halted prematurely; IRB approval not obtained
-
NCT05537935
Details
2023-06-12
Interventional
4-
Naltrexone
Acquired Immuno… HIV Infections Immunologic Def… Neuralgia Chronic Neuropa… Human Immunodef…
Recruitment has been temporarily paused for IRB review
-
NCT05411679
Details
2023-06-12
Interventional
20 
Olaparib
Lung Neoplasms Small Cell Lung… Stomach Neoplas… Gastric Cancer Small-cell Lung…
Futility analysis decision to terminate EP0057 compound and all Ellipses sponsored studies involving EP0057.
-