Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00793338
Details
2023-06-26
Interventional
40 
Sildenafil Citr…
Heart Failure
The project was not funded and could not be initiated.
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NCT04995978
Details
2023-06-23
Interventional
20 
Pioglitazone
Insulin Resista… Prostatic Neopl… Prostate Cancer
No participants were recruited and the study was deemed not feasible
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NCT04987294
Details
2023-06-23
Interventional
219 
Rasburicase
Gout Hyperuricemia Kidney Diseases Renal Insuffici… Chronic Kidney …
Company Financing
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NCT04502433
2020-002632-75
Details
2023-06-23
Interventional
222 
Poractant alfa
Acute Lung Inju… Respiratory Dis… Respiratory Dis… Syndrome Acute Respirato…
The enrolment was extended. Nevertheless, despite the Sponsor's attempts, the infection status did not permit the identification of eligible patients for the study to complete it in a reasonable time.
Once the impact of the Covid 19 pandemic significantly declined and intubated patients with acute respiratory distress syndrome (ARDS) outcome became rare, the Sponsor considered it unfeasible to maintain efforts to recruit further patients into the study. Thus, due to low recruitment, the study was terminated early for non-safety reasons.
NCT04194034
Details
2023-06-23
Interventional
1/215 
Flucytosine
Colorectal Neop…
Study has been terminated after Phase I part on 23 February 2023
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NCT03724071
Details
2023-06-23
Interventional
1/251 
Flucytosine
Colorectal Neop… Digestive Syste… Gastrointestina… Neoplasms Colorectal Neop… Digestive Syste…
Study has been terminated after Phase I part on 23 February 2023
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NCT02554812
2015-002552-27
Details
2023-06-23
Interventional
1/2409 
Avelumab
Neoplasms Advanced Cancer
The study was terminated since there was no need for further safety or efficacy data to be collected. The participants having benefit from the Investigational treatments have been moved to a continuation study (NCT05059522)
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NCT01308437
Details
2023-06-23
Interventional
3134 
Insulin Insulin, Globin… Isophane Insuli…
Diabetes Mellit… Type I Diabetes
Business reasons
-
NCT05128773
2021-000398-10
Details
2023-06-22
Interventional
33 
Tamoxifen
Breast Neoplasm… Breast Cancer
Sponsor decision to prematurely stop the study, not linked to any safety concern
Due to premature discontinuation and closure of study decided by the Sponsor, only safety data were summarized and reported, and no efficacy data was collected.
NCT04766996
Details
2023-06-22
Interventional
457 
Acetaminophen Aspirin Bupivacaine Diclofenac Ketorolac Trome… Lidocaine Meloxicam Omeprazole Prednisone Pregabalin Propofol Tramadol Tranexamic Acid
Opioid-Related … Anesthesia Opioid Use
Loss of surgery team member deemed the study procedures impossible to achieve, and no replacement could be found in a timely manner to complete trial as initially planned.
This study aimed to enroll a total of 170 participants. Due to staffing issues and the coronavirus disease 2019 (COVID-19) pandemic, this trial was terminated early and therefore the retrospective data was not collected.
NCT04650204
Details
2023-06-22
Interventional
44 
Anticonvulsants
Drug Resistant … Epilepsies, Par… Epilepsy Glioma Seizures Intractable Epi… Malignant Gliom… Seizure Disorde… WHO Grade 2 Gli… WHO Grade 3 Gli…
The funding sponsor, EISAI, sold the US rights to the medication and can no longer provide it to patients for the study.
Study was terminated due to the funding sponsor(EISAI) sold the US rights to the medication and can no longer provide it to patients for the study.
NCT04109482
Details
2023-06-22
Interventional
1/23 
Cyclophosphamid… Fludarabine
Neoplasms Blastic Plasmac…
Business reasons.
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NCT04094584
Details
2023-06-22
Interventional
4179 
Naltrexone
Alcohol Drinkin… Alcoholism Emergencies Substance-Relat… Alcohol Abuse o… Alcohol Use Dis… Substance Use
12 month follow up data not collected due to pandemic disruptions
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NCT03458416
Details
2023-06-22
Interventional
22 
Cannabidiol
Prader-Willi Sy… Syndrome
Insys Therapeutics filed Chapter 11 and terminated all studies.
This study was terminated by the Sponsor. The Sponsor terminated the study due to slow enrollment and a failure to identify adequate participants that met eligibility criteria. Due to study termination and only 2 participants being enrolled there are concerns regarding participant confidentiality, therefore no data are being reported.
NCT03399448
Details
2023-06-22
Interventional
1
[1 Refs]
3 
Cyclophosphamid… Fludarabine
Liposarcoma Liposarcoma, My… Multiple Myelom… Sarcoma, Synovi… Melanoma Myxoid/Round Ce… Synovial Sarcom…
Sponsor has terminated trial to pursue other targets.
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NCT01326312
Details
2023-06-22
Interventional
2159 
Leuprolide
Prostatic Neopl… Prostate Cancer
FDA Clinical Hold
Study terminated early
NCT00675922
Details
2023-06-22
Interventional
2/398 
Mafenide Silver Nitrate
Burns Burn
Data inconclusive.
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NCT05908513
Details
2023-06-18
Interventional
10 
Acetylcysteine N-monoacetylcys…
Atherosclerosis Diabetes Mellit… Inflammation Peripheral Arte… Atherosclerosis… Oxidative Stres… Peripheral Arte…
Lack of available resources needed to conduct study.
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NCT05553405
Details
2023-06-18
Interventional
10 
Soybean oil, ph…
Obesity
No longer able to run study
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NCT05442684
Details
2023-06-18
Interventional
30 
Vaccines
COVID-19
The trial protocol was not approved by the regulatory authorities.
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