Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00003910
Details
2023-07-05
Interventional
259 
Cyclophosphamid… Methotrexate Prednisone
Leukemia
-
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NCT03933397
Details
2023-07-03
Interventional
3328 
Hydromorphone Morphine
Anemia, Sickle … Sickle Cell Dis…
Due to COVID enrollment numbers needed to meet the primary endpoint will not be met.
-
NCT02150967
2013-005085-19
Details
2023-07-03
Interventional
2143 
Infigratinib
Cholangiocarcin… Advanced Cholan… FGFR2 Gene Muta…
The study was terminated early due to limited efficacy in Cohorts 2 and 3 (exploratory endpoints). Termination was not due to concerns about safety and had no impact on the primary efficacy analysis (ie, results reported for Cohort 1).
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NCT05614453
Details
2023-06-29
Interventional
20 
Tislelizumab
Uterine Cervica… Metastatic Cerv…
BeiGene has withdrawn their support owing to sitravatinib supply concerns. Mirati is ceasing further development of sitravatinib owing to the negative results of the SAPPHIRE trial which used sitravatinib in 2nd line met NSCLC setting.
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NCT04487392
Details
2023-06-29
Interventional
20 
Estrogens
Atrophy Vulvovaginal At…
The student do not start the study
-
NCT03126539
Details
2023-06-29
Interventional
29 
Sulforaphane
Aging
For administrative reasons, we started a new study
-
NCT02101021
2014-004480-20
Details
2023-06-29
Interventional
325 
Gemcitabine N-(cyanomethyl)… Paclitaxel
Adenocarcinoma Metastatic Panc…
-
-
NCT04955574
Details
2023-06-28
Interventional
20 
Anti-Bacterial … Antibiotics, An… Metronidazole
Endometriosis Infertility Unexplained Inf…
Change in departmental research focus.
-
NCT04662073
Details
2023-06-28
Interventional
22 
Camostat
COVID-19 Covid19
Enrollment into the camostat subprotocol was halted prematurely as a result of loss of equipoise due to external findings including those related to monoclonal antibodies.
This study did not meet its planned enrollment and did not achieve statistical power as specified in the protocol.
NCT04639310
2020-002396-35
Details
2023-06-28
Interventional
38 
Ezogabine
Brain Diseases Central Nervous… Epilepsy Epileptic Syndr… Nervous System … Seizures Disease Epilepsy in Chi… Epilepsy; Seizu…
Sponsor decision; Not a safety decision
-
NCT04559347
Details
2023-06-28
Interventional
2-
Bupivacaine Ropivacaine
Thoracic Surger…
Reviewing randomization process
-
NCT03805841
Details
2023-06-28
Interventional
241 
Bromides
Carcinoma, Non-… EGFR Exon 20 In… ERBB Fusion HER2-activating… NRG1 Fusion NSCLC Stage III… NSCLC, Recurren… NSCLC, Stage II… NSCLC, Stage IV
enrollment pause
-
NCT02519439
Details
2023-06-28
Interventional
326 
Ganaxolone
Seizures Drug Resistant …
Ganaxolone missed its primary endpoint in the double-blind portion of the 1042-0603 study. Due to this outcome Marinus discontinued this extension study.
-
NCT02033941
Details
2023-06-28
Interventional
2-
Phenol
Alzheimer Disea… Alzheimer's Dis…
Study has been suspended for the duration of the pandemic. We hope to re-start enrollment later this year
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NCT04865029
Details
2023-06-27
Interventional
210 
Estradiol Estradiol 17 be… Estradiol 3-ben… Polyestradiol p… Progesterone
COVID-19 Covid19
Lack of enrollment due to change of COVID 19 variant prevalence
Early termination leading to small numbers of subjects analyzed
NCT04294459
2019-004154-28
Details
2023-06-27
Interventional
1/223 
Acetaminophen Diphenhydramine Methylprednisol… Montelukast Promethazine Ranitidine
Immune System D… Immune System D…
Terminated due to non-safety reasons
Sponsor decided to terminate the study for non-safety reasons on 02 May 2022. Based on available clinical data at time of interim analysis, it was determined that enrollment of the remaining participants was unlikely to have any significant impact on the study results and hence the trial was stopped. All 23 participants enrolled in the study were followed-up per protocol until the planned study termination date.
NCT02640534
Details
2023-06-27
Interventional
2169 
Metformin
Prostatic Neopl… Cancer of the P… Prostate Cancer
The decision is based on the fact that with the current follow up of around 10 years, the relevant secondary endpoints can adequately be addressed according to protocol. The addition of follow up data will not significantly impact these results.
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NCT01307605
2010-021253-39
Details
2023-06-27
Interventional
2154 
Lenalidomide Rituximab
Lymphoma Lymphoma, Folli…
It was decided by the trial team to stop the collection of follow up data in trial SAKK 35/10.
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NCT03395314
Details
2023-06-26
Interventional
222 
Ketamine Midazolam
Borderline Pers… Personality Dis…
assessment of project in wake of covid-19 related interruptions
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NCT02932475
Details
2023-06-26
Interventional
3831 
Metformin
Diabetes Mellit… Pregnancy Compl… Diabetes Pregnancy
Recommendation by the DSMB that the study be stopped for futility
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