Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04231279
Details
2024-04-03
Interventional
327 
Secretin
Abdominal Pain Exocrine Pancre… Irritable Bowel…
Data collection discontinuity and sponsor reallocation of study resources to manufacturing
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NCT04060862
2019-001072-11
Details
2024-04-03
Interventional
320 
Fulvestrant Ipatasertib Palbociclib
Breast Neoplasm… Breast Cancer
The decision to not open the Phase III portion was based on a strategic sponsor decision and not driven by any safety concerns.
-
NCT03866980
Details
2024-04-03
Interventional
3164 
Carboplatin Pemetrexed
Carcinoma, Non-… Lung Neoplasms Lung Cancer Non…
corporate strategy adjustment
-
NCT02540330
Details
2024-04-03
Interventional
23 
Fulvestrant
Breast Neoplasm… Carcinoma Carcinoma in Si… Carcinoma, Duct… Carcinoma, Intr… Female Breast C… Female Ductal C…
Business decision (See Detailed Description)
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NCT02373241
Details
2024-04-03
Interventional
21 
Losartan
Anemia, Sickle … Hypertension Kidney Diseases Proteinuria Kidney Disease Sickle Cell Dis…
Estimated GFR was determined not to be a reliable endpoint for this study. We identified significant variabilty in annual eGFR that it became inappropriate to randomize to a medication but use EGFR as the primary endpoint.
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NCT06205290
Details
2024-04-02
Interventional
30 
Bendamustine Hy… Cyclophosphamid… Fludarabine Idelalisib Rituximab
Leukemia Leukemia, Lymph… Leukemia, Lymph… Lymphoma
Business objectives have changed.
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NCT05400122
Details
2024-04-02
Interventional
1-
Cyclophosphamid… Fludarabine Fludarabine pho… Vactosertib
Colorectal Neop… Hematologic Neo… Leukemia Leukemia, Lymph… Leukemia, Myelo… Leukemia, Myelo… Lymphoma Multiple Myelom… Myelodysplastic… Neoplasms Precursor Cell … Rectal Neoplasm… Syndrome Acute Lymphobla… Acute Myeloid L… Chronic Lymphoc… Chronic Myeloid… Colorectal Canc… Hematologic Mal… Hodgkin Lymphom… Myeloproliferat… Non Hodgkin Lym… Plasma Cell Mye… Rectum Cancer
Insufficient staff
-
NCT05362474
Details
2024-04-02
Interventional
35 
Montelukast
Diabetic Nephro… Kidney Diseases Diabetic Kidney…
Funding not available
-
NCT05013437
Details
2024-04-02
Interventional
10 
Acetaminophen Diphenhydramine Melphalan Prochlorperazin… Promethazine
Multiple Myelom… Neoplasms, Plas…
The original principal Investigator left the institution.
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NCT04610658
Details
2024-04-02
Interventional
19 
Ipilimumab Nivolumab
Lung Neoplasms Recurrence Small Cell Lung… Recurrent Small… Relapsed Small … Small-cell Lung…
DLTs
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NCT03127124
Details
2024-04-02
Interventional
1/20 
Bevacizumab Calcium Fluorouracil Leucovorin Levoleucovorin Oxaliplatin
Adenocarcinoma Pancreatic Aden…
This study was withdrawn due to no enrollment
-
NCT06137651
Details
2024-04-01
Interventional
10 
Vinorelbine
Breast Neoplasm… Neoplasms Neoplasms, Seco… Breast Carcinom… Metastatic Mali… Metastatic Mali…
Study terminated by the sponsor
-
NCT05617625
Details
2024-04-01
Interventional
2-
Busulfan Fludarabine Melphalan
Graft vs Host D… Myelodysplastic… Preleukemia Syndrome Graft Vs Host D… Graft-versus-ho…
The study has been put on hold while pending CMS approval
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NCT04945733
Details
2024-04-01
Interventional
262 
Amivantamab-vmj…
Esophageal Neop… Neoplasms Stomach Neoplas…
Due to reconsideration of development strategy
-
NCT06083883
Details
2024-03-29
Interventional
1-
Cyclophosphamid… Fludarabine Fludarabine pho…
Liposarcoma Liposarcoma, My… Sarcoma Sarcoma, Synovi… Myxoid/Round Ce… Synovial Sarcom…
Activate and Hold per IND office
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NCT05815186
Details
2024-03-29
Interventional
20 
Sotorasib
Carcinoma, Non-… Lung Neoplasms Advanced Non-sm…
Study record has been combined with NCT05815173 (Phase I/II study).
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NCT05289492
Details
2024-03-29
Interventional
1/216 
Dexamethasone
Multiple Myelom… Neoplasms, Plas…
Company operational decision. Decision to stop study is not due to safety or efficacy concerns
-
NCT04300114
Details
2024-03-28
Interventional
35 
Fluzoparib
Pancreatic Neop… Metastatic Panc…
Sponsor R & D Strategy Adjustment
-
NCT03983824
Details
2024-03-28
Interventional
1-
Cytarabine Etoposide Etoposide phosp… Mitoxantrone Peposertib
Leukemia Leukemia, Myelo… Leukemia, Myelo… Recurrent Acute… Refractory Acut…
Scheduled Interim Monitoring
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NCT03743025
Details
2024-03-28
Interventional
431 
Dulaglutide
Hyperglycemia Stress Hypergly…
The study was terminated following the Data and Safety Monitoring Board (DSMB) review due to concerns with perioperative use of the study drug.
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