Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT05171062
Details
2023-07-20
Interventional
10 
Pembrolizumab
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
No participants were enrolled, the study was inactivated with the IRB on May 15, 2023. The sponsor notified the PI that a Phase II trial had been allowed to proceed by the FDA.
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NCT03968640
Details
2023-07-20
Interventional
30 
Coenzyme Q10
Multiple Organ …
Sponsor terminated award
-
NCT03932318
Details
2023-07-20
Interventional
1/20 
Azacitidine Lintuzumab Venetoclax
Acute Myeloid L… Relapsed Adult …
study postponed
-
NCT02824354
Details
2023-07-20
Interventional
30 
Nalmefene
Alcoholism Fibrosis Liver Cirrhosis Alcohol Depende… Cirrhosis Nalmefene
no participants enrolled
-
NCT05641298
Details
2023-07-19
Interventional
20 
Fusidic Acid
Cystic Fibrosis Fibrosis Pulmonary Fibro… Cystic Fibrosis…
Corporate finances
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NCT02592707
2015-002867-41
Details
2023-07-19
Interventional
1/240 
1,4,7,10-tetraa… Antiemetics Dexamethasone Ondansetron
Neuroendocrine …
Terminated (Due to small number of ongoing patients. Patients ongoing at time of termination could choose to join study D-FR-01072-004 for long term follow-up.
Due to strategic reasons, the Ipsen management team decided to early terminate the D-FR-01072-001 / OPS-C-001 study. This decision was not due to any safety or tolerability concern, or any event associated with the use of the study drug.
NCT00792740
2007-000189-19
Details
2023-07-19
Interventional
1/251 
Givinostat hydr…
Crohn Disease Crohn's Disease
As no safety warnings were detected, Interim analysis from the first 40 patients recommends to stop the trial for futility
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NCT05244070
2021-003274-31
Details
2023-07-18
Interventional
15 
Cyclophosphamid… Fludarabine
Leukemia Leukemia, Lymph… Leukemia, Lymph… Lymphoma
Business objectives have changed.
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NCT04505098
Details
2023-07-18
Interventional
439600 
Eicosapentaenoi…
Atherosclerosis Cardiovascular … Respiratory Tra… Covid19 Upper Respirato…
The study was suspended by the IRB of record and subsequently terminated
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NCT00677924
Details
2023-07-18
Interventional
1/2
[1 Refs]
9 
Zalutumumab
Colorectal Neop… Colorectal Canc…
Due to changes in portfolio review
The trial was prematurely closed when 9 out of 97 patients were enrolled. The trial design was originally divided in two parts. Patient allocation was terminated before Part 2 was started.
NCT05400577
Details
2023-07-17
Interventional
20 
Sotorasib
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
Grantor withdrew support due to slow accrual
-
NCT03152786
Details
2023-07-17
Interventional
246 
Propranolol
Prostatic Neopl… Prostate Carcin…
PIs not interested in continuing with the trial.
-
NCT02478320
Details
2023-07-17
Interventional
212 
Ilorasertib
Advanced Cancer…
Study terminated due to company's decision to discontinue drug development
-
NCT04736745
2019-003268-33
Details
2023-07-14
Interventional
156 
abobotulinumtox…
Facies Moderate Upper … Severe Upper Fa…
Sponsor terminated the study due to strategic considerations
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NCT03740100
Details
2023-07-14
Interventional
28 
MTOR Inhibitors
Squamous Cell C… HNSCC
The trial was closed because the sponsor became insolvent.
The trial was closed early because the sponsor became insolvent.
NCT02309645
2013-003558-26
Details
2023-07-14
Interventional
340 
Fibrin Tissue A…
Cerebrospinal F… CSF Leak
Study completed the required elements (40 paediatric subjects) per regulatory requirement. The study enrolled 40/42 subjects. No safety signals were identified. No changes required to the statistical analysis as described in the protocol.
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NCT00788125
Details
2023-07-14
Interventional
1/27 
Carboplatin Dasatinib Etoposide Etoposide phosp… Ifosfamide
Central Nervous… Liver Neoplasms Lymphoma Neoplasms Neoplasms, Germ… Nervous System … Neuroblastoma Sarcoma Brain and Centr… Childhood Germ … Extragonadal Ge… Kidney Cancer Liver Cancer Ovarian Cancer Testicular Germ… Unspecified Chi…
Terminated early due a shift in resources after lackluster performance of the drug.
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NCT05109052
Details
2023-07-13
Interventional
1/20 
Atezolizumab Bevacizumab
Carcinoma Carcinoma, Hepa… Liver Neoplasms Cancer of Liver Hepatocellular …
no accrual of eligible participants
-
NCT04335461
Details
2023-07-13
Interventional
10 
Anesthetics Anesthetics, Lo…
Fractures, Bone Hip Fractures Pain, Postopera… Analgesia Opioid Use
Study was withdrawn. Study expired in IRB system and no patients enrolled as per institutional CTMS and IRB systems. Primary and Study Completion Dates reflect date IRB approval expired.
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NCT01784159
Details
2023-07-13
Interventional
2167 
Aspirin
Sepsis Shock, Septic Toxemia
Terminated: The study was stopped prematurely and will not be resumed due to the higher number of bleeding cases in the intervention group, as recomended by the Data Safety Monitoring Board on February 7, 2023.
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