Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04507204
Details
2023-07-27
Interventional
4267 
Methylphenidate
Attention Defic… Hyperkinesis Attention-Defic…
(due to administrative reasons not related to efficacy or safety.)
-
NCT04120987
Details
2023-07-27
Interventional
40 
Lifitegrast Ophthalmic Solu…
Cataract Dry Eye Syndrom… Inflammation Dry Eye
Administrative
-
NCT03613792
Details
2023-07-27
Interventional
40 
Fentanyl Ketamine Midazolam Remifentanil
Bronchoscopy
Change in procedure means limited value for study question
-
NCT03417921
Details
2023-07-27
Interventional
1/2-
Gemcitabine Paclitaxel
Pancreatic Neop… Pancreatic Canc…
We opened another study.
-
NCT02749292
Details
2023-07-27
Interventional
4115 
Rituximab
Anti-Neutrophil… Vasculitis
Due to the coronavirus disease 2019 (COVID-19) pandemic and the deleterious impact of rituximab on vaccination efficacy, the trial was concluded before reaching the target enrollment of 200.
The trial has several limitations: It was open-label. it only enrolled patients on continuous B cell depletion for a minimum of 2 years it took place in a single center.
NCT05119439
Details
2023-07-25
Interventional
423 
Mifepristone Misoprostol
Medical Abortio…
Enrollment
-
NCT04334629
Details
2023-07-25
Interventional
40 
Ibuprofen
Respiratory Dis… Respiratory Dis… Severe Acute Re… Coronavirus SARS-CoV Infect…
Study withdrawn.
-
NCT03669133
Details
2023-07-25
Interventional
23 
Vitamin E
Fatty Liver Non-alcoholic F… HIV Infections NAFLD NASH - Nonalcoh…
lack of coordinator resources and lack of access to study resources during and due to the COVID pandemic
-
NCT02663518
Details
2023-07-25
Interventional
1250 
Immunoglobulin … Nivolumab Rituximab
Hematologic Neo… Neoplasms Hematologic Mal… Solid Tumor
Pfizer decided terminating study for administrative reasons on 22Mar2022 (stopping enrollment as of 15Apr2022). The decision wasn't due to safety concerns or requests from regulatory authorities.
-
NCT05809895
2022-503099-99
Details
2023-07-24
Interventional
20 
Albumin-Bound P… Carboplatin Gemcitabine Paclitaxel Pembrolizumab Tislelizumab
Breast Neoplasm… Triple Negative… Triple Negative…
Business decision, not driven by safety concerns; no new safety signals have been observed in the ociperlimab program.
-
NCT05791097
2022-503098-12
Details
2023-07-24
Interventional
30 
Albumin-Bound P… Carboplatin Paclitaxel Pembrolizumab Pemetrexed Tislelizumab
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
Business decision, not driven by safety concerns; no new safety signals have been observed in the ociperlimab program.
-
NCT05338658
Details
2023-07-24
Interventional
1-
Pembrolizumab
Neoplasm Metast… Neoplasms Metastasis Solid Tumor
Pending final IP
-
NCT05074433
2021-005222-14
Details
2023-07-24
Interventional
366 
Casirivimab and…
COVID-19 Immunocompromis…
Emerging SARS-CoV2 variants impacting susceptibility to study drug
-
NCT04016805
Details
2023-07-24
Interventional
241 
Acalabrutinib Ibrutinib Venetoclax
Leukemia Leukemia, Lymph… Leukemia, Lymph… Chronic Lymphoc…
Strategic/Business decision
Due to sponsor's business decision, the clinical trial was terminated by the sponsor prematurely. No analysis was done at the termination of the trial, therefore, outcome, and safety data are not available and the numbers of participants analyzed are reported as "0".
NCT03338920
Details
2023-07-24
Interventional
3159 
Sumatriptan
Migraine Disord… Acute Migraine …
eDiary data collected not sufficient to utilize in the analysis of protocol endpoints
-
NCT02710396
Details
2023-07-24
Interventional
219 
Carboplatin Paclitaxel Pembrolizumab Pemetrexed
Carcinoma Carcinoma, Non-…
Frontline pembrolizumab approved in NSCLC as monotherapy and in combination with chemotherapy representing a new standard of care.
-
NCT04964843
Details
2023-07-21
Interventional
20 
Acetylcysteine N-monoacetylcys…
Alcohol Drinkin… Alcoholism Alcohol Use Dis…
Null results were posted from a neurometabolite study and a recent trial for AUD. Study may resume if more positive data emerge.
-
NCT04860518
Details
2023-07-21
Interventional
27 
Dexamethasone
COVID-19 Covid19
The decision is based on changes in the pandemic and further weakening of the recruitment that will not enable a completion of the study in any reasonable time
No formal statistical hypotheses were analysed due the early termination of the study with only 5 dosed subjects.
NCT04407442
Details
2023-07-21
Interventional
25 
Azacitidine BB 1101 Daratumumab Dexamethasone Dexamethasone a… Ichthammol
Multiple Myelom… Neoplasms, Plas… Recurrent Plasm… Refractory Plas…
Slow enrollment and change in sponsor direction
-
NCT03336242
Details
2023-07-21
Interventional
220 
Cannabidiol
Epilepsy, Absen… Seizures Childhood Absen…
More patients in Cohort 1 than Cohort 2 demonstrated a clinically meaningful reduction of seizure count. Given this, enrollment of Cohort 3 was discontinued.
This study was prematurely terminated by the Sponsor. Enrollment of Cohort 3 was discontinued.