Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04688931
Details
2023-08-03
Interventional
3282 
Mitomycin Mitomycins
Carcinoma Carcinoma, Tran… Non-Muscle Inva… Urinary Bladder… Bladder Cancer Urothelial Carc… Urothelial Carc…
Alternate approach pursued
-
NCT04362293
Details
2023-08-03
Interventional
2-
Alemtuzumab Azathioprine Cyclophosphamid… Hydroxyurea MTOR Inhibitors Plerixafor Sirolimus Temsirolimus Thiotepa
Anemia, Sickle … Sickle Cell Dis…
We are holding enrollment, due to some recent SAEs.
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NCT03024996
2016-001881-27
Details
2023-08-03
Interventional
3778 
Atezolizumab
Carcinoma Carcinoma, Rena… Renal Cell Carc…
The sponsor decided to terminate this study before the protocol-defined end-of-study, as permitted per protocol.
-
NCT02748564
Details
2023-08-03
Interventional
210 
Aldesleukin Interleukin-2 Pembrolizumab
Melanoma Melanoma, Cutan… Skin Neoplasms Metastatic Mela… Stage III Mucos… Stage IIIA Skin… Stage IIIB Skin… Stage IIIC Skin… Stage IV Skin M… Stage IVA Mucos… Stage IVB Mucos… Stage IVC Mucos…
Study Complete
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NCT00707655
Details
2023-08-03
Interventional
1/28 
Zalutumumab
Carcinoma Carcinoma, Squa… Head and Neck N… Head and Neck C… Squamous Cell C…
The decision is based on company re-evaluation of indications to be pursued within SCCHN
All adverse events were collected during the 8 week treatment period and for 4 additional weeks. Serious adverse events were collected for the extended follow-up period of 2 years.
NCT00488605
Details
2023-08-03
Interventional
30 
Leucovorin Levoleucovorin Methotrexate Prednisone Vinblastine
Histiocytosis Histiocytosis, … Leukemia
This is a duplicate record and the sponsor has registered the study.
-
NCT05926206
Details
2023-08-02
Interventional
1/20 
Folfirinox
Adenocarcinoma Metastatic Panc…
based some additional data, we have decided to hold off this trial for now and will not be proceeding with this particular trial
-
NCT05238207
Details
2023-08-02
Interventional
124 
Psyllium
Hemochromatosis Hemosiderosis Hereditary Hemo…
Only Part A (single dosing) was conducted due to business considerations
-
NCT03662074
Details
2023-08-02
Interventional
214 
Gemcitabine Nivolumab
Lung Neoplasms Small Cell Lung… Stage IV Lung C… Stage IVA Lung … Stage IVB Lung …
After interim analysis decided not to move forward with continuing the trial.
-
NCT04971187
Details
2023-08-01
Interventional
23 
Carboplatin Cisplatin Pemetrexed
Carcinoma Carcinoma, Non-… Lung Neoplasms Locally Advance… Metastatic Lung… Stage III Lung … Stage IIIA Lung… Stage IIIB Lung… Stage IIIC Lung… Stage IV Lung C… Stage IVA Lung … Stage IVB Lung … Unresectable Lu…
PI Request
The study was terminated early due to the drug company no longer producing the drug.
NCT04901299
Details
2023-08-01
Interventional
20 
Fulvestrant Neratinib
Breast Neoplasm… ER Positive Bre… HER2-negative B… Invasive Breast… Metastatic Brea… PR-Positive Bre… Stage IV (Metas…
Team decision
-
NCT04882072
Details
2023-08-01
Interventional
314 
Ustekinumab
Aortic Arch Syn… Arteritis Takayasu Arteri…
Due to difficulties in enrollment and ongoing feasibility issues
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NCT03956056
Details
2023-08-01
Interventional
112 
Carboxymethylce… Poly I-C Poly ICLC
Pancreatic Neop… Cancer of the P… Pancreas Cancer Pancreatic Canc…
Insufficient funding/staff
-
NCT03277482
Details
2023-08-01
Interventional
116 
Durvalumab Tremelimumab
Carcinoma Carcinoma, Ovar… Endometrial Neo… Ovarian Neoplas… Recurrence Uterine Cervica… Vaginal Neoplas… Vulvar Neoplasm… Metastatic Cerv… Metastatic Endo… Metastatic Ovar… Metastatic Vagi… Metastatic Vulv… Recurrent Cervi… Recurrent Endom… Recurrent Gynec… Recurrent Ovari… Recurrent Vagin… Recurrent Vulva…
Expansion cohort was not open
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NCT02844933
Details
2023-08-01
Interventional
27 
Cannabidiol
Prader-Willi Sy… Syndrome
Insys Therapeutics filed Chapter 11 and terminated all studies.
This study was prematurely terminated by the previous Sponsor (Insys Therapeutics Inc.). Only 7 participants were enrolled, and the planned number of participants was not achieved.
NCT02059265
Details
2023-08-01
Interventional
235 
Dasatinib
Adenocarcinoma,… Carcinoma Cystadenocarcin… Recurrence Endometrial Cle… Ovarian Clear C… Recurrent Fallo… Recurrent Ovari… Recurrent Prima… Recurrent Uteri…
Interim monitoring
-
NCT05177796
Details
2023-07-28
Interventional
20 
Albumin-Bound P… Antibodies Antibodies, Mon… Antineoplastic … Carboplatin Cyclophosphamid… Daunorubicin Doxorubicin Immunoglobulins Liposomal doxor… Paclitaxel Panitumumab Pembrolizumab
Breast Neoplasm… Carcinoma Inflammatory Br… Anatomic Stage … Anatomic Stage … Anatomic Stage … Anatomic Stage … Anatomic Stage … Breast Inflamma… Invasive Breast… Prognostic Stag… Prognostic Stag… Prognostic Stag… Prognostic Stag… Prognostic Stag… Triple-Negative…
0 participants recruited
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NCT04561180
Details
2023-07-28
Interventional
20 
Dexamethasone
COVID-19 Pneumonia COVID-19 Pneumo…
No patients COVID-19 morbidity decreased.
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NCT02618577
2015-003997-33
Details
2023-07-28
Interventional
32608 
Edoxaban
Atrial High Rat…
following a recommendation from the data safety and monitoring board due to safety concerns and a tendency towards futility.
-
NCT05961007
Details
2023-07-27
Interventional
1/2-
Aflibercept
Edema Macular Degener… Macular Edema Wet Macular Deg… Diabetic Macula… Neovascular Age…
Company strategy adjustment
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