Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03594175
2019-002124-32
Details
2023-08-09
Interventional
3462 
Reteplase Tissue Plasmino…
Thrombosis Catheter Occlus…
Due to ongoing recruitment challenges globally, it is not possible to complete this study. The decision is not based on any reported changes in the safety profile or any concerns with the anticipated efficacy profile of the investigational product.
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NCT02792413
Details
2023-08-09
Interventional
44 
Denosumab
Kidney Diseases Osteoporosis Renal Insuffici… Female With Ost…
Modified study and new deposit in RECHMPL21_0451
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NCT05758818
Details
2023-08-08
Interventional
16 
Moxifloxacin
Cardiac Repolar…
sponsor decision
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NCT05222516
Details
2023-08-08
Interventional
263 
Broncho-Vaxom
Dermatitis Dermatitis, Ato… Eczema Atopic Dermatit…
Recommendation of DSMB (futility of Endpoints)
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NCT04398368
Details
2023-08-08
Interventional
225 
Gemcitabine
Kidney Neoplasm… Pelvic Neoplasm… Ureteral Neopla… Stage 0a Renal … Stage 0a Renal … Stage 0a Ureter… Stage 0is Renal… Stage 0is Renal… Stage 0is Urete… Stage I Renal P… Stage I Renal P… Stage I Ureter … Stage II Renal … Stage II Renal … Stage II Ureter… Stage III Renal… Stage III Renal… Stage III Urete… Stage IV Renal … Stage IV Renal … Stage IV Ureter…
Focus research efforts on other projects.
Study target enrollment was anticipated for 90 participants but only 23 participants completed treatment before study was terminated. The study was terminated due to insufficient resources and funding to support continuation of the trial. PI decision to terminate.
NCT04224688
2019-003451-11
Details
2023-08-08
Interventional
330 
Rozanolixizumab
Purpura, Thromb… Thrombocytopeni… Primary Immune …
Strategic Business Decision; Not a safety decision
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NCT04204122
Details
2023-08-08
Interventional
20 
Moxifloxacin
Graft vs Host D… Ocular Graft-ve…
Investigator decided to close study
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NCT04200456
2019-000884-26
Details
2023-08-08
Interventional
333 
Rozanolixizumab
Purpura, Thromb… Thrombocytopeni… Primary Immune …
Strategic Business Decision; Not a safety decision
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NCT03330457
Details
2023-08-08
Interventional
218 
Betrixaban
Bleeding
Ended prematurely
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NCT05399550
Details
2023-08-07
Interventional
20 
Balovaptan
Cerebral Infarc… Ischemia Ischemic Stroke Stroke Acute Ischemic …
Sponsor's decision
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NCT04969991
Details
2023-08-07
Interventional
218 
Varespladib met…
COVID-19 Coronavirus Inf… Severe Acute Re… Syndrome Coronavirus Dis… Disease Caused …
Part 2 of the study was paused on 03-May-2022 due to slow enrollment following low infection rates and hospitalizations of patients with severe COVID-19, and did not recommence prior to study closure (early termination) on 22-Nov-2022.
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NCT04782245
2020-005713-40
Details
2023-08-07
Interventional
20 
Dapagliflozin
Heart Failure End-stage Heart…
New recommandations
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NCT04680962
Details
2023-08-07
Interventional
30 
Rituximab
Arthritis Arthritis, Rheu… Rheumatoid Arth…
Study closed for business reasons before patient recruitment was initiated.
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NCT04644315
Details
2023-08-07
Interventional
21 
Alectinib
Brain Neoplasms Bronchial Neopl… Carcinoma, Bron… Cholangiocarcin… Colonic Disease… Colorectal Neop… Digestive Syste… Digestive Syste… Gastrointestina… Gastrointestina… Head and Neck N… Intestinal Dise… Intestinal Neop… Lymphoma, Large… Melanoma Neoplasms Neoplasms by Si… Neuroendocrine … Ovarian Neoplas… Pancreatic Neop… Respiratory Tra… Respiratory Tra… Salivary Gland … Sarcoma Thoracic Neopla… Thyroid Cancer,… Thyroid Disease… Thyroid Neoplas… Central Nervous…
The data from this study is no longer needed.
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NCT04544995
2020-002359-39
Details
2023-08-07
Interventional
1-
Dostarlimab Niraparib
Neoplasms
The study was paused for enrolment to further assess clinical data
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NCT03788694
Details
2023-08-07
Interventional
10 
Ketamine
Suicidal Ideati…
Study was never funded nor started, no participants were enrolled
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NCT04972968
2021-000648-23
Details
2023-08-04
Interventional
2181 
Glucocorticoids
Giant Cell Arte… Polymyalgia Rhe…
Business Decision
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NCT03926143
2019-000061-20
Details
2023-08-04
Interventional
29 
Anetumab ravtan… Maytansine Tubulin Modulat…
Neoplasms Solid Tumors
Due to strategic company decisions, the development of anetumab ravtansine was stopped.
Due to the small sample size and heterogeneous population, survival distributions and the extent of long-term survival in the applicable populations cannot be reliably estimated from the study results. Overall results were reported. Pooling was done because there is only a single patient treated with combination and no summary tables on a single patient.
NCT02774291
Details
2023-08-04
Interventional
13 
Aldesleukin Cyclophosphamid… Fludarabine Fludarabine pho… Interleukin-2 Lenograstim
Neoplasms Neoplasms, Seco… HLA-A2 Positive… Metastatic Mali… Metastatic Mali…
Due to lack of accrual the study was formally terminated on 01-JUL-2020. Primary Completion and Study Completion Dates have been revised based accordingly based on respective definitions
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NCT02689024
2015-003650-40
Details
2023-08-04
Interventional
4239 
Acetaminophen Bupivacaine Diclofenac Dipyrone Fentanyl Ibuprofen Levobupivacaine Morphine Naproxen Ropivacaine
Delirium Hip Fractures Anesthesia
recruitment too slow; intervention was standard care in patients who were not included; acute care pathways changed due to policy regarding hip fracture patients
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