Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04871529
Details
2023-08-15
Interventional
2-
Antibodies, Mon… Avelumab Carboplatin Gemcitabine Immunoglobulin … Immunoglobulins
Carcinoma Carcinoma, Tran… Urinary Bladder… Bladder Carcino… Infiltrating Re… Stage II Bladde…
undergoing nrevision
-
NCT02568618
Details
2023-08-15
Interventional
127 
Analgesics
Pain
Sponsor pulled funding related to enrollment pace.
-
NCT00871065
Details
2023-08-15
Interventional
20 
Sildenafil Citr…
Hemorrhage Subarachnoid He… Vasospasm, Intr… Cerebral Vasosp…
PI decision
-
NCT00792662
Details
2023-08-15
Interventional
40 
Methylphenidate
Alzheimer Disea… Dementia Diabetes Mellit… Alzheimer's Dis… Apathy
No Subjects enrolled
-
NCT05608070
Details
2023-08-14
Interventional
40 
Oxytocin
Pain, Postopera… Analgesia Oxytocin Pain, Post Oper… Postoperative P…
Sponsor declined to fund
-
NCT05516849
Details
2023-08-14
Interventional
30 
Oxandrolone
Wounds and Inju… Trauma Injury
FDA requested manufacturers of Oxandrolone Tablets, to voluntarily remove previously approved drug applications for Oxandrolone from the U.S. market & the funding decided to prematurely terminate the funding.
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NCT05401227
Details
2023-08-14
Interventional
1-
Ketamine
Healthy
U.S. Department of Health and Human Services OHRP issued an FWA restriction on NYSPI research that included a pause of human subjects research as of June 23, 2023. This study will resume recruitment after OHRP has approved the resumption of research.
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NCT05114460
Details
2023-08-14
Interventional
2-
Naloxone
Opiate Overdose Opioid Overdose
The U.S. Department of Health and Human Services Office of Human Research Protections issued an FWA restriction on NYSPI research that included a pause of human subjects research as of June 23, 2023.
-
NCT05061654
Details
2023-08-14
Interventional
40 
Ceftolozane Ceftolozane, ta… Tazobactam
Febrile Neutrop… Hematologic Neo… Neutropenia Hematologic Can… Neutropenia, Fe…
Administrative constraints
-
NCT05011513
2021-002857-28
Details
2023-08-14
Interventional
2/31440 
Nirmatrelvir Ritonavir
COVID-19
Enrollment ceased due to a very low rate of hospitalization or death observed in the standard-risk patient population
In participant flow, there was discontinuations due to AE, which was captured under "Death" as reason for discontinuation. Adverse event was COVID-19 pneumonia and the participant died due to that event and discontinued study.
NCT04826133
Details
2023-08-14
Interventional
14 
Calcitriol Dihydroxycholec…
Cocaine Use Dis…
Could not obtain additional funding to continue the research.
-
NCT04729725
Details
2023-08-14
Interventional
13 
Antibodies Antibodies, Mon… Cemiplimab
Neoplasms Advanced Malign… Metastatic Mali… Unresectable Ma…
The industry supporter discontinued the study and lead drug, SAR439459, due to toxicity.
-
NCT04091750
Details
2023-08-14
Interventional
2-
Ipilimumab Nivolumab
Melanoma
futility stage with the first 14 subjects completed
-
NCT03192995
Details
2023-08-14
Interventional
2
[1 Refs]
22 
Cocaine
Cocaine Use Dis…
FDA alert regarding study drug safety
The study was terminated early by the FDA due to the publication of a long-term safety study that showed an increase risk for cancer by the lorcaserin arm.
NCT02536300
2015-000366-66
Details
2023-08-14
Interventional
396 
Idelalisib
Lymphoma Lymphoma, Folli… Follicular Lymp…
Gilead has made the decision to close the study due to enrollment challenges
-
NCT02125968
Details
2023-08-14
Interventional
470 
Oxymetazoline
Back Pain Low Back Pain Chronic Low Bac…
-
-
NCT00455039
Details
2023-08-14
Interventional
1/20 
Lapatinib
Breast Neoplasm… Breast Cancer
This is a duplicate record and the sponsor has submitted under NCT00206427.
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NCT05156658
Details
2023-08-09
Interventional
40 
Etonogestrel
HIV-1-infection
Protocol's question was answered elsewhere and very low site interest in the trial
-
NCT05095961
Details
2023-08-09
Interventional
2/30 
Prednisone
Chronic Disease Ethmoid Sinusit… Paranasal Sinus… Sinusitis Sphenoid Sinusi… Chronic Sinus D… Chronic Sinusit… Chronic Sinusit… Chronic Sinusit… Chronic Sinusit…
Technical difficulties encountered with recording intraoperative blood loss; unable to proceed with study.
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NCT04272242
Details
2023-08-09
Interventional
2-
Anti-Retroviral… Dolutegravir Isoniazid Pyridoxal Pyridoxine Rifapentine Vitamin B 6
HIV Infections HIV Infection LTBI
Following completion of Arm 1, A5372 is currently Temporarily Closed. Timeline for opening of Arm 2 is not available.
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