Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04360551
Details
2023-08-21
Interventional
224 
Telmisartan
COVID-19
Decrease in COVID-19 cases locally
The number of individuals involved in the study was extremely small. The study was terminated early because the number of infections in the community substantially decreased. As an outpatient study, the study only involved individuals with mild to moderate COVID-19 infection, as those severely ill with acute COVID-19 infections may have been hospitalized.
NCT04227275
Details
2023-08-21
Interventional
116 
Cyclophosphamid… Fludarabine Interleukin 1 R…
Prostatic Neopl… Metastatic Cast…
Based on the safety events and evidence of biologic activity without sustained clinical responses the Sponsor finds the risk/benefit analysis unfavorable for patients and has terminated the study.
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NCT04119336
Details
2023-08-21
Interventional
22 
Cyclophosphamid… Dexamethasone Ixazomib Nivolumab
Multiple Myelom… Neoplasms, Plas… Refractory Mult… Relapsed Multip…
Study closure initiated by industry funding sponsor for commercial reasons.
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NCT03901612
Details
2023-08-21
Interventional
40 
Ropivacaine
Post Operative …
covid and surgeon left
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NCT03626545
2018-002480-26
Details
2023-08-21
Interventional
3245 
Docetaxel
Carcinoma, Non-… Lung Neoplasms Non-Small-Cell …
The study was early terminated due to the lack of efficacy of study treatment observed in the analysis of the primary endpoint of the randomized part
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NCT02647892
Details
2023-08-21
Interventional
470 
Lidocaine
Local Anesthesi…
IRB protocol administratively closed, Continuing Review or Study Completion Report not submitted
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NCT05677373
Details
2023-08-18
Interventional
1/20 
Trametinib
Melanoma Uveal Neoplasms Advanced Uveal … Metastatic Uvea… Unresectable Uv…
The drug company supporting this trial has withdrawn support, including the ability to provide study agent.
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NCT05221749
Details
2023-08-18
Interventional
350 
Fluorides
Communicable Di… Dental Caries Infections Caries Dental Caries i… Microbial Colon… Primary Teeth
Only the 1 month follow-up was completed. The principal investigator could not complete the 3 month follow-up appointments and was not calibrated with other dentists who were available at the time.
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NCT05063734
2020-000362-42
Details
2023-08-18
Interventional
216 
Aflibercept
Diabetic Retino… Edema Macular Edema Diabetes Mellit… Diabetic Macula…
Based on data obtained in Part A, there was insufficient evidence of efficacy on the key outcome measures. As a result, the study was not advanced to Part B.
Based on data obtained in Part A, there was insufficient evidence of efficacy on the key outcome measures. As a result, the study was not advanced to Part B
NCT04647084
Details
2023-08-18
Interventional
40 
Lidocaine
Acute Pain Pain, Acute Patient Satisfa…
The investigators were unable to begin work on this study.
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NCT03713801
Details
2023-08-18
Interventional
118 
Metformin
Aging Vaccine Respons…
Study has been halted due to COVID-19 pandemic, immunity of the subject has been a concern. Modifications are planned for the protocol.
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NCT05131204
2020-002761-33
Details
2023-08-16
Interventional
32 
Eculizumab Ravulizumab
Hemoglobinuria Hemoglobinuria,… Paroxysmal Noct…
Sponsor decision not related to efficacy or safety.
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NCT05106335
Details
2023-08-16
Interventional
31 
Docetaxel
Advanced NSCLC
Sponsor R & D Strategy Adjustment
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NCT03377725
Details
2023-08-16
Interventional
30 
Arsenic Trioxid… Decitabine
Myelodysplastic… Preleukemia Syndrome P53 Mutation
No patient was involved.
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NCT01982760
Details
2023-08-16
Interventional
214 
Deamino Arginin…
Ecchymosis Postoperative E…
-
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NCT01465100
Details
2023-08-16
Interventional
1/21 
Liver Extracts
Phenylketonuria… Phenylketonuria
Study was funded by NIH grant; grant funding ended in June 2023 without enrollment of additional subjects; the only subject enrolled was in 2011.
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NCT01011478
Details
2023-08-16
Interventional
3
[1 Refs]
406 
Rosuvastatin Ca…
Colonic Neoplas… Precancerous Co… Colorectal Canc… Precancerous Co…
-
Early termination leading to small numbers of subjects analyzed.
NCT05993143
Details
2023-08-15
Interventional
3249 
Ivermectin
COVID-19 SARS-CoV-2
Study was stopped because no statistically significant difference was observed in the interim analysis. With high vaccine rates in those over 50 and an expected low incidence, it would not be feasible to complete recruitment within a short period.
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NCT05510427
Details
2023-08-15
Interventional
10 
Atezolizumab Bevacizumab Infigratinib
Cholangiocarcin… Liver Cancer
Per PI's request
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NCT05205252
Details
2023-08-15
Interventional
1/20 
Acalabrutinib Antibodies, Mon… Daratumumab Dexamethasone Lenalidomide Pomalidomide Tyrosine Kinase…
Hematologic Neo… Neoplasms Refractory Hema… Relapsed Hemato…
Epizyme Inc. has revised the Tazemetostat development strategy and made the decision to terminate the hematological malignancies basket trial.
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