Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04227938
Details
2023-08-28
Interventional
11 
ALPN-101
Graft vs Host D… Graft Vs Host D…
Change in sponsor strategy
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NCT02122185
Details
2023-08-28
Interventional
2-
Metformin
Adenocarcinoma Ascites Brenner Tumor Carcinoma Carcinoma, Endo… Carcinoma, Ovar… Cystadenocarcin… Cystadenocarcin… Fallopian Tube … Germinoma Neoplasms, Germ… Ovarian Neoplas… Peritoneal Neop… Pleural Effusio… Pleural Effusio… Recurrence Malignant Ascit… Malignant Pleur… Ovarian Clear C… Ovarian Endomet… Ovarian Mixed E… Ovarian Serous … Ovarian Undiffe… Recurrent Fallo… Recurrent Ovari… Recurrent Ovari… Recurrent Prima… Stage IIIA Fall… Stage IIIA Ovar… Stage IIIA Ovar… Stage IIIA Prim… Stage IIIB Fall… Stage IIIB Ovar… Stage IIIB Ovar… Stage IIIB Prim… Stage IIIC Fall… Stage IIIC Ovar… Stage IIIC Ovar… Stage IIIC Prim… Stage IV Fallop… Stage IV Ovaria… Stage IV Ovaria… Stage IV Primar…
Enrollment halted for planned interim analysis.
-
NCT05935774
Details
2023-08-25
Interventional
20 
Atezolizumab Trabedersen
Carcinoma Carcinoma, Non-… Lung Neoplasms Metastatic Lung… Recurrent Lung … Stage IV Lung C…
Withdrawn prior to opening to accrual.
-
NCT05926440
Details
2023-08-25
Interventional
30 
Somatomedin B Vaccines
COVID-19
we has selected a new candidate vaccine which is monovalent.
-
NCT05276830
Details
2023-08-25
Interventional
25 
Dexmedetomidine
Dementia Psychomotor Agi… Agitation
Study was terminated for business reasons; not due to safety or efficacy concerns
The study was terminated prematurely due to business reasons. There were no Safety or Efficacy Concerns.
NCT03139370
2020-005456-37
Details
2023-08-25
Interventional
116 
Cyclophosphamid… Fludarabine
Solid Tumor
The study was terminated due to the sponsor's decision to discontinue the clinical trial.
-
NCT02740920
Details
2023-08-25
Interventional
29 
Pembrolizumab
Melanoma Metastatic Mela…
-
-
NCT05567770
Details
2023-08-24
Interventional
10 
Androgens
Prostatic Neopl… Prostate Cancer…
Stakeholder elected not to proceed with the study
-
NCT03606174
Details
2023-08-24
Interventional
2260 
Nivolumab Pembrolizumab
Carcinoma Carcinoma, Tran… Urinary Bladder… Urothelial Carc… Urothelial Carc… Urothelial Carc… Urothelial Carc… Urothelial Carc…
The study was terminated due to sponsor decision / portfolio prioritization, and not due to safety reasons.
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NCT03450707
Details
2023-08-24
Interventional
293 
Thiamine
Heart Arrest Cardiac Arrest
DSMB recommendation based on differing mortality in a subgroup analysis
The study was stopped early by the Data Safety and Monitoring Board (DSMB) due to a signal of increased mortality in the thiamine group with a lactate > 5
NCT04299438
Details
2023-08-23
Interventional
3164 
Propranolol
Pregnancy, Prol…
Stopped at interim analysis
-
NCT03736629
Details
2023-08-23
Interventional
2
[1 Refs]
17 
Azithromycin
Asthma Asthma Chronic
Inability to accrue patients, particularly after COVID pandemic.
Early termination leading to small numbers of subjects analyzed.
NCT01618357
Details
2023-08-23
Interventional
1-
Veliparib
Breast Neoplasm… Breast Cancer
final subject consented to dose level 4
-
NCT00662740
2007-005134-36
Details
2023-08-23
Interventional
3220 
Salmeterol Xina… Tiotropium Brom…
Lung Diseases Pulmonary Disea…
-
-
NCT03695250
Details
2023-08-22
Interventional
1/28 
Linrodostat Nivolumab
Carcinoma Carcinoma, Hepa… Metastatic Hepa… Stage III Hepat… Stage IIIA Hepa… Stage IIIB Hepa… Stage IV Hepato… Stage IVA Hepat… Stage IVB Hepat… Unresectable He…
Funding source decision to terminate study.
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NCT03329378
Details
2023-08-22
Interventional
27 
Albumin-Bound P… Carboplatin Cyclophosphamid… Docetaxel Doxorubicin Paclitaxel Pertuzumab Trastuzumab
Breast Neoplasm… Locally Advance…
Data Safety Monitoring Board is in agreement with the study findings so far and the stopping rule has been met, which suspends the study treatment arms in March 2021.
-
NCT02906332
Details
2023-08-22
Interventional
212 
Dexamethasone Lenalidomide Pembrolizumab
Multiple Myelom… Neoplasms, Plas…
FDA Hold Due to Updated Risks
-
NCT00489710
Details
2023-08-22
Interventional
20 
Enzyme Inhibito… Immunomodulatin…
Carcinoma, Rena… Kidney Neoplasm… Kidney Cancer
safety reasons
-
NCT04886986
Details
2023-08-21
Interventional
1/2-
Gallium 68 PSMA…
Prostatic Neopl… Prostate Cancer
Need to wait until a new collaborator is available and confirmed
-
NCT04802837
Details
2023-08-21
Interventional
32 
Ridinilazole Vancomycin
Clostridium Inf… Communicable Di… Infections Clostridioides …
SMT19969-C006 study was terminated in alignment with corporate decision to pursue further development of drug candidate with a partner.
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