Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03852992
Details
2023-09-13
Interventional
20 
Minoxidil
Alopecia Alopecia Areata Androgenetic Al… Male Pattern Ba… Male Pattern Ha…
Study was closed with IRB on 10/22/22
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NCT03425006
Details
2023-09-13
Interventional
223 
Pembrolizumab
Carcinoma, Non-… Lung Neoplasms Non Small Cell …
Administrative reasons
-
NCT01093183
Details
2023-09-13
Interventional
1/225 
Cyclophosphamid… Lenalidomide
Prostatic Neopl… Adenocarcinoma … Hormone-resista… Recurrent Prost…
study sponsors withdrew support for the study drug.
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NCT05201001
Details
2023-09-11
Interventional
20 
Carboplatin
Carcinoma, Ovar… Ovarian Neoplas… Ovarian Cancer
IMP provider company (Apexigen) is sold, thus both IMP and grant is terminated
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NCT04099888
Details
2023-09-11
Interventional
241 
Gemcitabine
Cholangiocarcin…
Recent results from a Phase 3 study are expected to change the standard of care for patients with inoperable CCA, rendering the RELEASE study challenging to complete and potentially inadequate for NDA approval.
Due to the early termination of this study, no definitive conclusions can be drawn since an insufficient number of participants was recruited. A reduced statistical analysis was conducted.
NCT00745316
Details
2023-09-11
Interventional
234 
Adenosine Adenosine A1 Re…
Heart Failure Renal Insuffici…
Company Decision
-
NCT05438498
Details
2023-09-08
Interventional
3550 
Cilgavimab and …
COVID-19 Infections SARS-CoV-2 Infe…
FDA withdrew EUA for AZD7442
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NCT05125978
Details
2023-09-08
Interventional
20 
Dipyrone Tramadol
Chronic Pain Pain, Chronic
Strategy review
-
NCT04970108
Details
2023-09-08
Interventional
30 
Empagliflozin Telmisartan
Diabetes Mellit… Diabetes Mellit… Hypertension Hypertension As… Type II Diabete…
Strategy review
-
NCT04666701
Details
2023-09-08
Interventional
20 
Butylscopolammo… Ketorolac Ketorolac Trome… Scopolamine
Acute Pain
Strategy review
-
NCT04593329
Details
2023-09-08
Interventional
20 
Dipyrone Tramadol
Acute Pain
Strategy review
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NCT03363659
Details
2023-09-08
Interventional
215 
Copper Disulfiram Temozolomide
Glioblastoma Glioblastoma Mu…
Investigator decision
-
NCT03201250
Details
2023-09-08
Interventional
1/211 
Dexamethasone
Multiple Myelom… Neoplasms, Plas… Refractory Mult… Relapsed/Refrac…
Phase I response to treatment was not as expected and the myeloma field in treatment has changed since initiating the study, so investigators felt the study should not be pursued into Phase II.
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NCT05758298
Details
2023-09-07
Interventional
10 
Nicotine
Betel Nut Cessa…
Have not received IRB approval.
-
NCT05176288
Details
2023-09-07
Interventional
20 
Avelumab Axitinib Palbociclib
Carcinoma Carcinoma, Rena… Advanced Clear …
The overall protocol will be changed in a new amendment, which will be resubmitted under the new IND.
-
NCT04046107
Details
2023-09-07
Interventional
1/20 
Cemiplimab
Hepatitis Hepatitis B Hepatitis B Vir…
Temporarily closed to enrollment
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NCT02209545
Details
2023-09-07
Interventional
447 
Misoprostol Pyridoxine Vitamin B 6
Hemorrhage Leiomyoma Myofibroma Fibroids
The study was prematurely closed due to low enrollment rates.
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NCT05835011
2022-501548-14
Details
2023-09-06
Interventional
2100 
Decitabine Magrolimab
Myelodysplastic… Preleukemia Syndrome
Termination due to discontinuation of magrolimab development in MDS.
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NCT05552859
2022-001485-35
Details
2023-09-06
Interventional
462 
Insulin Insulin Glargin… Insulin, Globin…
Diabetes Mellit… Diabetes Mellit… Renal Insuffici… Renal Impairmen… Type 2 Diabetes…
Sponsor decision to cancel trial due to poor recruitment/ severe recruitment delay and not related to safety concern.
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NCT04421378
2021-000080-67
Details
2023-09-06
Interventional
1/274 
Bevacizumab Carmustine Lomustine Temozolomide
Glioblastoma Glioblastoma Mu…
Upon further consideration of the existing data and the competitive landscape, Karyopharm Therapeutics Inc has decided not to pursue the ongoing development of Selinexor in GBM at this time.
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