Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT05435053
2020-004623-17
Details
2023-09-15
Interventional
29 
Nivolumab
Pancreatic Neop… Pancreas Cancer
The study was terminated on the basis on an evaluation of the safety and efficacy of the 9 included patients of which 2 of the patients were excluded before receiving any study treatments, thus 7 patients were treated in the study.
-
NCT04780269
Details
2023-09-15
Interventional
4-
Dinoprostone
Induced Deliver… Labor Induction
understaffed
-
NCT04536363
Details
2023-09-15
Interventional
20 
Alprostadil
COVID-19 Covid19
Delays in approval by the national regulatory authority
-
NCT04328714
Details
2023-09-15
Interventional
1-
Interferon-gamm… Interferons
Myelodysplastic… Acute Leukemia
Study is suspended pending renovation and reopening of the facility manufacturing the study product.
-
NCT03854500
2018-003090-95
Details
2023-09-15
Interventional
3201 
Tenecteplase Tissue Plasmino…
Cerebrovascular… Ischemic Stroke Stroke Stroke, Acute
Per protocol safety analysis 200 patients showed a significant difference in bleeding rates between the two drug groups.
-
NCT05994183
Details
2023-09-14
Interventional
10 
Dexamethasone
Bronchiolitis
The study was withdrawn with no participants enrolled due to the need for an IND from the FDA, which significantly expanded the scope of the study beyond what was originally anticipated for a pilot project within this network.
-
NCT05394350
2021-006712-93
Details
2023-09-14
Interventional
1/227 
Pembrolizumab
Neoplasms Advanced Solid …
Business Reasons
-
NCT04499235
Details
2023-09-14
Interventional
26 
Mometasone Furo…
Pemphigoid, Bul…
The study was prematurely terminated by the Sponsor due to operational challenges stemming from the coronavirus disease 2019 (COVID-19) pandemic, treatment limitations, rarity of the disease, and drug supply considerations.
-
NCT01996605
Details
2023-09-14
Interventional
220 
Oxytocin
Healthy Volunte…
Cessation of funding period prior to completion, due to slow recruitment during the pandemic
The study was powered for a sample size of 40 and was terminated early with a sample size of 20 due to slow recruitment and cessation of financial support.
NCT05535023
Details
2023-09-13
Interventional
20 
Cemiplimab
Carcinoma Carcinoma, Squa… Oropharyngeal N… Head and Neck C… Oropharynx Canc… Squamous Cell C…
PI Request
-
NCT05315479
Details
2023-09-13
Interventional
419 
Meloxicam
Pain, Postopera… Post Operative …
Anjeso (N1539) NDA Withdrawn
-
NCT05243524
Details
2023-09-13
Interventional
216 
Cyclophosphamid…
Carcinoma, Ovar… Ovarian Neoplas… Platinum-resist…
Closure of IMV operations
-
NCT04834349
Details
2023-09-13
Interventional
20 
Pembrolizumab
Carcinoma Carcinoma, Squa… Recurrence Squamous Cell C… Recurrent Head … Unresectable He…
No participants were enrolled
-
NCT04749797
Details
2023-09-13
Interventional
411 
Bupivacaine
Craniotomy Surg…
PI left institution
Study concluded before reaching subject n goal due to slow enrollment related to COVID-19 pandemic and PI leaving institution. Sample size not significant enough to accurately analyze data.
NCT04485130
Details
2023-09-13
Interventional
211 
Disulfiram
COVID-19 Covid19
Low COVID case numbers, competing COVID treatments available
-
NCT04458948
Details
2023-09-13
Interventional
228 
Azithromycin Hydroxychloroqu…
COVID-19
The World Health Organization (WHO) paused Hydrochloroquinone from its Solidarity Trial in order to conduct a safety data review by the Data Safety Monitoring Board of the WHO to evaluate HCQ in its clinical trials.
-
NCT04208516
Details
2023-09-13
Interventional
417 
Dexamethasone Dexmedetomidine Lidocaine Ropivacaine
Pain, Postopera… Postoperative P…
Recruitment was unable to be obtained in a timely fashion, so the study was stopped.
We were not able to enroll enough subjects in a timely manner and our enrollment numbers did not reach the goal of our pilot study.
NCT04181255
Details
2023-09-13
Interventional
12 
Poractant alfa
Heart Defects, … Heart Diseases Hypoplastic Lef… Congenital Hear…
Investigator Retirement
-
NCT04079738
Details
2023-09-13
Interventional
1/28 
Ixazomib
AML AML, Adult
Funder requested termination due to halting internal development of TAK-659
-
NCT03860207
Details
2023-09-13
Interventional
1/212 
Antibodies Antibodies, Bis… Immunoglobulins
Neuroblastoma Osteosarcoma Other Solid Tum…
study terminated due to business priorities
The study was terminated after 11 subjects due to a business strategy decision. At this point the maximum tolerated dose was not established.