Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03915405
2018-003796-35
Details
2023-10-03
Interventional
116 
Avelumab
Carcinoma Carcinoma, Tran… Urothelial Carc…
Termination was based on the business decision
-
NCT03477162
Details
2023-10-03
Interventional
118 
Metformin
Thoracic Neopla… Thoracic Neopla…
Enrollment was closed as efforts had become more challenging, and the lab indicated that they were able to obtain their primary objective with the number that had already been enrolled.
-
NCT02100956
Details
2023-10-03
Interventional
28 
Oxytocin
Neuralgia Neuropathic Pai…
Cessation of funding period prior to completion, due to slow recruitment during the pandemic
This study was terminated early due to slow recruitment and lack of funding.
NCT04683939
2022-001843-25
Details
2023-10-02
Interventional
1/213 
Gemcitabine Paclitaxel
Adenocarcinoma Biliary Tract N… Cholangiocarcin… Esophageal Neop… Neoplasm Metast… Pancreatic Neop… Stomach Neoplas… Biliary Tract C… Esophageal Aden… Gastric Cancer Gastroesophagea… Metastatic Canc… Pancreatic Canc… Solid Tumor
Sponsor decision
-
NCT04203901
Details
2023-10-02
Interventional
216 
Everolimus Ipilimumab Lenvatinib Nivolumab
Carcinoma Carcinoma, Rena… Advanced Renal …
Strategic corporate decision
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NCT04171700
Details
2023-10-02
Interventional
283 
Rucaparib
Neoplasms Solid Tumor
The study was terminated due to a change in development priorities.
-
NCT03197506
Details
2023-10-02
Interventional
252 
Pembrolizumab Temozolomide
Glioblastoma Gliosarcoma Supratentorial …
Temporary closure per protocol design
-
NCT05323617
Details
2023-09-29
Interventional
20 
Antilymphocyte … Cyclosporine Cyclosporins
Anemia Anemia, Aplasti… Severe Aplastic…
Operational
-
NCT04713176
Details
2023-09-29
Interventional
3240 
Remdesivir
COVID-19 Severe COVID-19
Termination of study due to sponsor's internal decision
-
NCT04254692
Details
2023-09-29
Interventional
4-
Bupivacaine
Pain, Postopera… Postoperative P…
division wide research suspension
-
NCT05887843
2023-000362-34
Details
2023-09-28
Interventional
138 
Azelastine Mometasone Furo…
Rhinitis Rhinitis, Aller… Rhinitis, Aller… Seasonal Allerg…
Business decision (no safety concerns).
-
NCT05374538
Details
2023-09-28
Interventional
14 
Sotorasib
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
Sponsor decision
-
NCT04768010
Details
2023-09-28
Interventional
10 
Misoprostol
Constipation Dilatation, Pat… Distension Gas Bloat Syndr…
After significant delays study was never initiated. No participants enrolled
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NCT02391545
2014-005459-13
Details
2023-09-28
Interventional
1/255 
Obinutuzumab Rituximab
Lymphoma Lymphoma, Folli… CD20+ Follicula…
Sponsor is focusing on studies which can enable registration of duvelisib.
-
NCT02204982
2013-002406-31
Details
2023-09-28
Interventional
313 
Rituximab
Lymphoma Lymphoma, Folli… Follicular Lymp…
Sponsor is focusing on studies which can enable registration of duvelisib
-
NCT00745134
Details
2023-09-28
Interventional
222 
Capecitabine Curcumin
Adenocarcinoma Adenocarcinoma,… Carcinoma, Sign… Cystadenocarcin… Rectal Neoplasm… Rectal Mucinous… Rectal Signet R… Recurrent Recta… Stage IIA Recta… Stage IIB Recta… Stage IIC Recta… Stage IIIA Rect… Stage IIIB Rect… Stage IIIC Rect…
The trial was stopped early because there was only one patient with pCR among the first 15 patients randomized to the curcumin arm.
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NCT05470400
Details
2023-09-25
Interventional
1-
Vaccines
HIV
Temporarily Closed (Paused) to Accrual
-
NCT04237649
2019-002841-39
Details
2023-09-25
Interventional
177 
Spartalizumab
Neoplasms Solid Tumors
Business reasons
-
NCT03565991
2018-000345-39
Details
2023-09-25
Interventional
2202 
Avelumab Talazoparib
Genes, BRCA 1 Locally Advance…
The study was terminated since there was no need for further safety or efficacy data to be collected. The participants having benefit from the investigational treatments have been moved to a continuation study (NCT05059522)
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NCT03165292
2015-003130-27
Details
2023-09-25
Interventional
234 
Thiotepa Topotecan
Neuroblastoma Very High Risk …
The Sponsor has been notified of an interruption in the international supply, and there is a possibility that 131I-mlBG would be unavailable to patients randomised to arm A of the trial
-