Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00580190
Details
2009-09-14
Interventional
147 
Alprazolam
Healthy
Date of termination was Feb. 7, 2008. Reasons of termination were due to elevation of liver function tests and long elimination half-life of the compound.
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NCT00788515
2008-001492-30
Details
2009-08-28
Interventional
333 
Lormetazepam Volinanserin
Sleep Initiatio…
Sponsor's decision due to absence of demonstration of efficacy of volinanserin in primary insomnia with predominant sleep maintenance problems
-
NCT00132951
Details
2009-08-27
Interventional
42051 
Azithromycin Telithromycin
Bronchitis Bronchitis, Chr… Communicable Di… Infections Respiratory Tra… Chronic Bronchi… Pneumonia
-
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NCT00505089
Details
2009-08-25
Interventional
1/211 
Antibodies, Mon…
Arthritis Arthritis, Rheu… Rheumatoid Arth…
-
-
NCT00434226
Details
2009-08-21
Interventional
256 
Bevacizumab Carboplatin Paclitaxel Sunitinib
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
Based on data collected, the combination appeared to be poorly tolearated.
Based on the early safety results from this study, Genentech halted further recruitment and discontinued treatment. Insufficient efficacy data was available to perform additional analyses and limited the interpretation of the analyses performed.
NCT00770354
Details
2009-08-10
Interventional
2-
Letrozole
Breast Neoplasm… Breast Carcinom…
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NCT00354900
Details
2009-08-04
Interventional
1-
Aprotinin
Breast Neoplasm… Metastatic Brea…
The FDA changed the labeling for this agent, and we felt we could not offer it to patients on a non-surgical study.
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NCT00693004
Details
2009-07-30
Interventional
2-
Donepezil
Alzheimer Disea… Alzheimer's Dis…
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NCT00947375
Details
2009-07-28
Interventional
4335 
Haloperidol Haloperidol dec… Lamotrigine
Schizophrenia
All of the mentioned aim and objectives were achieved before the February 2007
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NCT00532025
Details
2009-07-28
Interventional
2-
Sorafenib
Carcinoma Carcinoma, Non-… Lung Neoplasms
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NCT00602680
2007-001639-80
Details
2009-07-20
Interventional
21 
Donepezil
Alzheimer Disea… Alzheimer's Dis…
Insufficient expected benefit risk
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NCT00434096
Details
2009-07-20
Interventional
3915 
Rimonabant
Dyslipidemias Obesity
Company decision taken in light of demands by certain national health authorities
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NCT00610792
Details
2009-07-14
Interventional
2-
Bortezomib Doxorubicin Liposomal doxor…
Carcinoma, Ovar… Ovarian Neoplas… Ovarian Cancer
Study never submitted to IND. Study is being sponsored by Johnson and Johnson in the EU only.
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NCT00601276
Details
2009-07-13
Interventional
3-
Cyproterone Cyproterone Ace… Leuprolide
Pedophilia
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NCT00314457
Details
2009-07-13
Interventional
416 
Bupivacaine
ACL Repair Bankart Repair Meniscectomy
Bupivacaine has recently been shown to inhibit osteoclast formation in vitro.
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NCT00595985
Details
2009-07-07
Interventional
25 
Sorafenib
Stomach Neoplas… Gastric Cancer
low response rate, no evidence of PFS or OS improved.
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NCT00929370
Details
2009-06-29
Interventional
134 
Glycine
Schizophrenia
Study has now been terminated due to changes in project strategy. Current available data will be analysed and reported in a synoptic study report.
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NCT00502294
Details
2009-06-25
Interventional
3-
Visilizumab
Colitis Colitis, Ulcera… Ulcer Intravenous Ste…
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NCT00117702
2005-000161-19
Details
2009-06-18
Interventional
2/324 
Everolimus Tacrolimus
Graft vs Host D…
safety reasons
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NCT00678483
2007-002492-14
Details
2009-06-17
Interventional
3331 
Rimonabant
Overweight Weight Loss Obesity
Company decision taken in light of demands by certain national health authorities
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