Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00537667
Details
2009-11-26
Interventional
222 
Interleukin 1 R…
Arthritis Arthritis, Rheu… Rheumatoid Arth…
The safety profile of combination therapy became unacceptable.
-
NCT00647972
Details
2009-11-23
Interventional
132 
Olanzapine
Healthy
during Period 1 due to numerous orthostatic AEs that occurred. Subsequently, RLD was reduced to 5 mg due to safety concerns.
-
NCT00391950
Details
2009-11-23
Interventional
3-
Zoledronic Acid
Prostatic Neopl… Prostate Cancer
-
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NCT00372710
Details
2009-11-23
Interventional
3-
Zoledronic Acid
Breast Neoplasm… Neoplasm Metast… Breast Cancer W…
-
-
NCT00494026
Details
2009-11-20
Interventional
24 
Carboplatin Pemetrexed
Lung Neoplasms Small Cell Lung… Small Cell Lung…
Study stopped early based on interim results of another trial, showing inferior activity of pemetrexed/carboplatin compared to etoposide/carboplatin in SCLC.
-
NCT00468260
Details
2009-11-19
Interventional
1-
Epothilone B
Neoplasms Advanced Malign…
pts. will be captured in core
-
NCT00780728
Details
2009-11-13
Interventional
3-
Sildenafil Citr…
Hypertension Hypertension, P… Pulmonary Arter…
-
-
NCT00244504
Details
2009-11-10
Interventional
3141 
Moxonidine
Heart Diseases Cardiac Disease Vascular Surger…
Study was stopped after pre-definied interim analysis because of no effects
-
NCT00440674
Details
2009-10-30
Interventional
418 
Paclitaxel
Coronary Artery… Dilatation, Pat…
-
-
NCT00447421
Details
2009-10-28
Interventional
1/29 
Pemetrexed
Carcinoma, Smal… Lung Neoplasms Small Cell Lung… SCLC Small Cell Lung…
Interim results of another trial showed inferior activity of treatment
The Study Phase 1 was stopped early based on interim results of another trial, showing inferior activity of pemetrexed/carboplatin compared to etoposide/carboplatin in extensive small cell lung cancer. The Study did not progress to Phase 2.
NCT00074334
Details
2009-10-21
Interventional
1/23 
Immunotoxins
Central Nervous… Nervous System … Brain and Centr…
Drug company withdrawal of support for investigational agent in this indication.
-
NCT00998608
Details
2009-10-20
Interventional
4
[5 Refs]
88 
Risperidone
Schizophrenia
terminated
-
NCT00368264
2005-004067-30
Details
2009-10-05
Interventional
2/31 
Infliximab
Lupus Erythemat… Lupus Nephritis Nephritis
Failure to recruit patients with membranous lupus nephritis not previously treated with azathioprine .
-
NCT00494338
Details
2009-10-01
Interventional
26 
Docetaxel
Prostatic Neopl… Metastatic Pros…
due to celecoxib safety issues
-
NCT00544180
Details
2009-09-25
Interventional
47 
Risedronic Acid
Osteoporosis
The trial was terminated due to lack of compliance with GCP regulations.
-
NCT00409344
Details
2009-09-22
Interventional
40 
Dexmedetomidine
Aneurysm Aortic Aneurysm Aortic Aneurysm… Aortic Aneurysm… Length of Stay Respiration, Ar… Sedation
Surgical approach changed therefore subject enrollment not possible.
Unable to enroll participants into the study
NCT00273507
Details
2009-09-18
Interventional
3-
Carboplatin Paclitaxel
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
-
-
NCT00000157
Details
2009-09-17
Interventional
3-
Aspirin
Cataract
-
-
NCT00929630
Details
2009-09-16
Interventional
365 
Fibrin Tissue A…
Fistula Rectal Fistula Anal Fistulas
Evident advantages of one treatment (seton) over the other (Tissucol Glue)
-
NCT00782041
Details
2009-09-15
Interventional
211 
Fluorouracil Folic Acid Leucovorin Levoleucovorin Oxaliplatin
Uterine Neoplas…
protocol violation
-