Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00167141
Details
2010-02-02
Interventional
241 
Contraceptive A… Contraceptive A…
Healthy
-
-
NCT00568971
Details
2010-01-27
Interventional
240 
Docetaxel
Stomach Neoplas… Gastric Cancer
The study has finished.
-
NCT00473486
2006-005970-26
Details
2010-01-27
Interventional
1/212 
Carboplatin Pemetrexed Sorafenib
Carcinoma, Non-…
Sorafenib administered in the combination with pemetrexed-carboplatin appears to enhance thrombocytopenia compared to historical data.
-
NCT00102284
Details
2010-01-27
Interventional
4
[1 Refs]
-
Levodopa Modafinil Rivastigmine
Healthy
-
-
NCT00378573
Details
2010-01-26
Interventional
217 
Bevacizumab Docetaxel Gemcitabine
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
Incidence of GI Perforation
Due to early termination of the study only 17/90 subjects enrolled. Efficacy analysis of Progression Free Survival and Overall Survival were not performed. Efficacy results limited to a descriptive summary of best overall response for each subject.
NCT00264134
Details
2010-01-20
Interventional
1/2-
Carboplatin Docetaxel Irinotecan
Carcinoma, Non-… Lung Neoplasms Extensive Stage… Non-small Cell …
-
-
NCT00451867
Details
2010-01-14
Interventional
3210 
Mycophenolic Ac…
Cystitis Cystitis, Inter… Interstitial Cy… Painful Bladder…
The major and primary reason for the study termination is the observed reduced efficacy of CellCept compared to placebo.
-
NCT00185874
Details
2010-01-13
Interventional
1-
Immunomodulatin…
Liver Neoplasms Liver Cancer
Study closed due to lack of funding
-
NCT00378547
Details
2010-01-01
Interventional
4147 
Acetaminophen BB 1101 Dexamethasone Dexamethasone a… Pregabalin
Pain, Postopera…
ENT surgery stopped at the recruiting hospital
-
NCT00678509
Details
2009-12-29
Interventional
1/2-
Monatide (IMS 3…
Breast Neoplasm… Breast Cancer
Lack of financial support
-
NCT00271323
2005-001276-12
Details
2009-12-23
Interventional
214 
Docetaxel
Carcinoma, Non-… Non-Small-Cell …
-
-
NCT00172068
Details
2009-12-23
Interventional
296 
Calcium Vitamin D Zoledronic Acid
Breast Neoplasm… Primary Breast …
-
-
NCT00317434
Details
2009-12-15
Interventional
1
[1 Refs]
12 
Lapatinib
Carcinoma, Ovar… Ovarian Neoplas… Ovarian Cancer
Due to unacceptable non-dose limiting toxicities, excessive treatment delays and limited clinical responses.
-
NCT00667901
Details
2009-12-11
Interventional
1-
Riluzole
Melanoma Melanoma (Skin)
All enrollment, treatment, follow-up & data analysis completed
-
NCT00176527
Details
2009-12-11
Interventional
2-
Docetaxel Estramustine Interferon alph… Interferon-alph… Interferons Isotretinoin
Prostatic Neopl… Prostate Cancer
accrual goal met
-
NCT00105105
Details
2009-12-11
Interventional
2-
Mifepristone
Alzheimer Disea… Alzheimer's Dis…
-
-
NCT00288223
Details
2009-12-09
Interventional
454 
Telithromycin
Acute Disease Bronchitis Bronchitis, Chr…
-
-
NCT00349986
Details
2009-12-07
Interventional
44 
Insulin Glargin…
Diabetes Mellit… Diabetes Mellit…
prematurely terminated due to loss of interest
-
NCT00434356
Details
2009-12-03
Interventional
246 
Bevacizumab Paclitaxel Sunitinib
Breast Neoplasm… Metastatic Brea…
Based on data collected, the combination appeared to be poorly tolearated.
Based on the early safety results from this study, further recruitment and treatment was halted. Insufficient efficacy data were available to perform all protocol-specified analyses and limited the interpretation of the analyses performed.
NCT00575848
Details
2009-11-26
Interventional
1-
Glycine
Psychotic Disor… Schizophrenia Schizoaffective…
Slow enrollment and due to personnel change there was no viable way to quantify glycine levels through imaging
-