Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03995641
Details
2023-10-11
Interventional
419 
Bupivacaine Triamcinolone A…
Pelvic Organ Pr… Prolapse Postoperative P… Sacrospinous Li… Trigger Point I…
Never received appropriate formulation.
-
NCT03190967
Details
2023-10-11
Interventional
1/2
[2 Refs]
12 
Temozolomide Trastuzumab
Brain Neoplasms Breast Neoplasm… Neoplasm Metast… Brain Cancer Brain Metastasi… Breast Cancer
The phase II portion was never started as we could no longer get the drug from the manufacturer.
-
NCT03093831
Details
2023-10-11
Interventional
25 
Ibrutinib
Lymphoma Lymphoma, B-Cel… Lymphoma, B-Cel…
Study did not meet the objectives and terminated early on 17 Jul 2020 due to poor recruitment
-
NCT05788328
Details
2023-10-10
Interventional
116 
Dabigatran Rosuvastatin Ca…
Overweight Healthy
The decision to terminate clinical development of lotiglipron is based on pharmacokinetic data from Phase 1 drug-drug-interaction studies and laboratory measurements of elevated transaminases in these Phase 1 studies as well as a Phase 2 study.
-
NCT05728372
Details
2023-10-10
Interventional
10 
Copper Pembrolizumab
Metastatic Mali…
withdrawn per PI
-
NCT05085574
Details
2023-10-10
Interventional
20 
Celecoxib Famotidine
COVID-19 Communicable Di… Coronavirus Inf… Infections Respiration Dis… Respiratory Tra… Virus Diseases 2019 Novel Coro… 2019 Novel Coro… 2019-nCoV Disea… 2019-nCoV Infec… COVID-19 Pandem… COVID-19 Virus … COVID-19 Virus … Coronavirus Dis… Covid19 SARS-CoV-2 Acut… SARS-CoV-2 Infe…
COVID environment, lack of site confidence to enroll subjects, sites not suited to study procedures, decline of potential inpatient subjects at site
-
NCT04907968
Details
2023-10-10
Interventional
131 
Carboplatin
Carcinoma, Ovar… Ovarian Neoplas… Platinum-sensit…
Study Terminated by Sponsor
-
NCT04700046
Details
2023-10-10
Interventional
30 
Mexiletine
Myotonic Dystro… Myotonic Dystro…
Assessing novel alternative study designs and regulatory pathways
-
NCT03403205
2017-004135-36
Details
2023-10-10
Interventional
3214 
Choline Tetrathiomolybd…
Hepatolenticula… Wilson Disease
Sponsor decision to terminate the program
-
NCT05493501
2022-002674-93
Details
2023-10-06
Interventional
38 
Albumin-Bound P… Carboplatin Gemcitabine Osimertinib Paclitaxel Pemetrexed
NSCLC
The study is being closed based on corporate changes at EQRx and is not related to any efficacy or safety issues with aumolertinib.
-
NCT04781647
Details
2023-10-06
Interventional
254 
Entecavir Interferon-alph… Interferons
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch… Hepatitis, Chro… Chronic Hepatit…
Study ABI-H0731-203 was terminated early by the study Sponsor for strategic reasons to prioritize research and development efforts on finite and curative HBV therapies.
Study ABI-H0731-203 was terminated early by the study Sponsor for strategic reasons to prioritize research and development efforts on finite and curative HBV therapies. As a result, not all subjects completed Week 48 and some outcome measures were impacted.
NCT04768569
Details
2023-10-06
Interventional
224 
Zonisamide
Deafness Hearing Loss Hearing Loss, N…
PINIHL Program terminated by DoD
-
NCT04512911
Details
2023-10-06
Interventional
10 
Anti-Arrhythmia…
Cardiomyopathie… Tachycardia Tachycardia, Ve… Ventricular Tac…
IRB approval expired 1/23/2023 and eclipsed the 6 month institutional window where study can be reinitiated via progress report. No enrollment has taken place.
-
NCT04419181
Details
2023-10-06
Interventional
2-
Ado-Trastuzumab… Carboplatin Docetaxel Maytansine Pertuzumab Trastuzumab
Breast Neoplasm… HER2-positive B…
Change in the landscape of current treatment of early stage breast cancer. Larger clinical trials answering similar questions are expected to result in the next few years.
-
NCT03971734
Details
2023-10-06
Interventional
17 
Regadenoson
Astrocytoma Glioblastoma Glioma Oligodendroglio… Anaplastic Astr… Anaplastic Olig… High Grade Glio…
Terminated [NCI decided to terminate ABTC Consortium due to NCI moving in different direction for Brain Cancer]
-
NCT05659459
Details
2023-10-05
Interventional
2-
Pioglitazone
COVID-19
Sponsor has financial issues - trial currently on hold
-
NCT04393454
Details
2023-10-05
Interventional
26 
Sirolimus
Neoplasms Cancer Metastatic Soli… Metastatic dMMR… Solid Tumor
Following discussion with the Cancer Center the PI elected to terminate the study. Completion dates reflect date of this decision
-
NCT04002037
Details
2023-10-05
Interventional
4120 
Dexamethasone Triamcinolone Triamcinolone A… Triamcinolone d… Triamcinolone h…
Tenosynovitis Trigger Finger … Trigger Finger
Preliminary analysis revealed no difference
-
NCT02606136
2023-000321-80
Details
2023-10-04
Interventional
221 
Mitogens
Muscular Dystro… Muscular Dystro… Duchenne Muscul…
Sponsor Decision
-
NCT05456269
Details
2023-10-03
Interventional
10 
Bisantrene Cytarabine Decitabine Decitabine and …
Leukemia Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Acute Myeloid L… Chronic Myelomo… Higher Risk Mye… Recurrent Acute… Refractory Acut…
commercial reason
-