Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00791544
2008-000809-10
Details
2010-08-04
Interventional
1/213 
Erlotinib Hydro… Sorafenib
Carcinoma Carcinoma, Hepa… Liver Carcinoma
Company decision to discontinue the AVE1642 development program, not due to any safety or efficacy concerns
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NCT00515736
Details
2010-07-30
Interventional
3
[1 Refs]
200 
Selenium Thiamine Vitamin E Vitamins Zinc
Critical Illnes… Hemorrhage Subarachnoid He… Cardiac Surgery Critically Ill … Trauma
enrollment was completed
-
NCT00460837
Details
2010-07-26
Interventional
4-
Picosulfate sod…
Colorectal Neop… Colorectal Canc…
Supply of adequate label was not provided to the MHRA
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NCT00964691
Details
2010-07-07
Interventional
4-
Chloroquine Fanasil, pyrime… Pyrimethamine Sulfadoxine
Malaria Malaria in Preg…
Low prevalence of malaria, high prevalence of reported allergy to sulphur drugs, high proportion of women not meeting the inclusion criterea.
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NCT00706186
Details
2010-07-07
Interventional
44 
Sodium Oxybate
Alzheimer Disea… Mild Alzheimer'…
Withdrawn by Investigator, protocol in revision
-
NCT00177853
Details
2010-07-02
Interventional
1-
Celecoxib Irinotecan
Pancreatic Neop… Pancreatic Canc…
terminated
-
NCT00793520
Details
2010-07-01
Interventional
32 
Levomilnacipran Milnacipran
Fibromyalgia Myofascial Pain…
-
Early termination leading to small numbers of subjects enrolled. Technical problems with MRI equipment resulted in early study termination. No analysis was performed.
NCT00102856
Details
2010-06-24
Interventional
4-
Dexpramipexole Pramipexole Rivastigmine
Healthy
-
-
NCT00319345
Details
2010-06-23
Interventional
2/3-
Mannitol
Brain Injuries Intracranial Hy… Severe Trauma B…
-
-
NCT00376181
Details
2010-06-22
Interventional
396 
Azilsartan medo… Pioglitazone
Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes
Combination formulation concerns
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NCT01026727
Details
2010-06-14
Interventional
22 
Anti-Retroviral…
HIV Infections Infections
For strategic buisness reasons.
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NCT00181181
Details
2010-05-28
Interventional
424 
Atorvastatin
Hypertension
Coronary flow by echo Doppler was obtainable in about 50% of subjects. The study was stopped early because of insufficient sample size to achieve adequate power
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NCT00209729
Details
2010-05-26
Interventional
1/2-
Docetaxel
Stomach Neoplas… Gastric Cancer
Registration is less
-
NCT00801151
NCT00801840
Details
2010-05-20
Interventional
1-
Vinorelbine Vorinostat
Malignant Solid…
-
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NCT01122342
Details
2010-05-13
Interventional
1/2-
Methyltestoster… Testosterone Testosterone 17… Testosterone en… Testosterone un…
Atrophic Vagini… Breast Neoplasm… Dyspareunia Vaginitis
Evaluating outcomes of current subjects pre further enrollment/dose reduction.
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NCT01119430
Details
2010-05-07
Interventional
250 
Fluoxetine
Depression Depressive Diso… Depressive Diso… Major Depressio…
interim analysis suggested no differences with whole sample
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NCT00275262
Details
2010-05-06
Interventional
225 
Leuprolide
Hodgkin Disease Lymphoma Lymphoma, Mantl… Lymphoma, Non-H… Multiple Myelom… Mantle Cell Lym…
-
The study was terminated early because of slow enrollment. For the primary endpoint, changes from baseline within each treatment group were analyzed. Between treatment group comparisons were not performed because the sample size was too small.
NCT00086346
Details
2010-04-28
Interventional
3607 
Cyclosporine Cyclosporins Sirolimus Tacrolimus
Liver Transplan…
-
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NCT00280007
Details
2010-04-22
Interventional
232 
Bevacizumab
Carcinoma Carcinoma, Hepa… Hepatocellular …
Safety concerns in the treatment arm
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NCT00882414
Details
2010-04-08
Interventional
226 
Ferric Compound…
Anemia, Iron-De… Inflammatory Bo… Iron Deficienci… Thrombocytosis Iron-Deficiency…
Main objective of study was met. Further recruitment was difficult.
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