Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01018810
Details
2011-07-29
Interventional
28 
Antibodies Immunoglobulins Interleukin-23
Psoriasis
The trial was terminated for several reasons, including complexities in development of LY2525623, but not because of safety concerns
Study BDAD was terminated early due to non-safety related complexities in LY2525623 development. Numerical summaries and statistical comparisons for the 8 patients enrolled are not appropriate and may be scientifically/clinically misleading.
NCT00839059
Details
2011-07-29
Interventional
114 
Lenalidomide
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
Results of an interim analysis and a hardly ongoing enrolment in the last 10 months in all six participating centres
-
NCT00613964
Details
2011-07-22
Interventional
4-
Diuretics Sodium Potassiu…
Heart Failure Renal Insuffici… Renal Failure
-
-
NCT00523458
Details
2011-07-22
Interventional
45 
Efavirenz Nevirapine
Tuberculosis HIV Infections
A delay in protocol approval and approval of laboratory sites in Salvador, Brazil left too little time for completion of enrollment into the study.
-
NCT00483275
2006-006205-83
Details
2011-07-21
Interventional
4-
Alfacalcidol Hydroxycholecal…
Renal Insuffici… Renal Insuffici… Accidental Fall… Aged Chronic Renal I…
No final agreement with sponsor
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NCT00670813
2005-003196-21
Details
2011-07-20
Interventional
2-
Modafinil
Depression Sleep Deprivati…
-
-
NCT00003561
Details
2011-07-20
Interventional
2-
Interferon-alph… Interferons Sargramostim
Leukemia Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo…
-
-
NCT00002778
Details
2011-07-20
Interventional
2-
Sargramostim
Leukemia Leukemia, Myelo… Leukemia, Myelo…
subject accrual and data analysis is completed.
-
NCT00730665
Details
2011-07-14
Interventional
281 
Esomeprazole
Gastroesophagea… Gastroesophagea…
This study has been placed on clinical hold by the sponsor due to operational reasons.
-
NCT00412750
NCT00376389
Details
2011-07-13
Interventional
3159 
Peginterferon a… Telbivudine
Hepatitis Hepatitis A Hepatitis B
Enrollment stopped for safety issues
-
NCT00743886
Details
2011-07-12
Interventional
2/3-
Mitogens
MCL Tear
-
-
NCT00118300
Details
2011-07-08
Interventional
10 
Capecitabine
Endometrial Neo… Uterine Cervica… Vaginal Neoplas… Cervical Cancer Endometrial Can… Ovarian Cancer Vaginal Cancer
Competing studies
-
NCT00844727
Details
2011-07-06
Interventional
2/338 
Rofecoxib
Colorectal Neop… Nasopharyngeal … Duodenal Polypo…
Drug withdrawal
-
NCT00590538
Details
2011-06-30
Interventional
1/29 
4-phenylbutyric… Genistein
Cystic Fibrosis Fibrosis
12/15/2008 Voluntarily placed on inactive status-requested by the PI
No analysis was completed on data collected; More clinically efficacious compounds have been identified which suggested that completion of this study might not be as critical as when initially proposed; therefore, the study was terminated by PI.
NCT00518193
Details
2011-06-30
Interventional
244 
Cetuximab
Uterine Cervica… Cervix Cancer
high rate of medullar aplasia with infectious troubles.
-
NCT00376259
Details
2011-06-30
Interventional
343 
Adefovir Adefovir dipivo… Telbivudine
Hepatitis Hepatitis A Hepatitis B
The study was not completed as planned and was terminated early with agreement from the European Medicines Agency (EMEA)
The study was not completed as planned and was terminated early with agreement from the European Medicines Agency (EMEA).
NCT00988507
Details
2011-06-28
Interventional
2-
Artesunate Ferroquine
Malaria Plasmodium Falc…
Company decision to modify the ferroquine development strategy; discontinuation not due to safety or activity unexpected findings
-
NCT01096745
Details
2011-06-23
Interventional
2-
Cisplatin Gemcitabine
Biliary Tract N… Locally Advance… Metastatic Bili…
Planning for randomized phase III trial for this issue.
-
NCT00806910
Details
2011-06-23
Interventional
40 
Conivaptan
Heart Failure
Sponsor support withdrawn
-
NCT00532285
Details
2011-06-23
Interventional
244 
Albumin-Bound P… Gemcitabine Paclitaxel
Breast Neoplasm… Breast Cancer
terminated
-